Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6070276 | 0.90 | KMT2A (0.44) | ALDH1A1TSHRKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL6070284 | 0.85 | KDM4E (0.45) | ALDH1A1KMT2AMEN1SMN1; SMN2KDM4E | |
| SCHEMBL9828915 | 0.84 | KDM4E (0.51) | ALDH1A1TSHRKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL9828908 | 0.84 | KDM4E (0.51) | ALDH1A1TSHRKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL13988283 | 0.80 | KMT2A (0.45) | ALDH1A1TSHRKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL9830815 | 0.76 | LMNA (0.45) | ALDH1A1TSHRKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL9830821 | 0.76 | LMNA (0.45) | ALDH1A1TSHRKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL10444412 | 0.75 | GAA (0.53) | ALDH1A1TSHRKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL2278045 | 0.75 | GAA (0.53) | ALDH1A1TSHRKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL10440896 | 0.74 | POLB (0.48) | ALDH1A1TSHRKMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1664026-B1 | MITOTIC KINESIN INHIBITORS | MERCK & CO INC (US) | 2009-01-21 | — | — | EP | disclosed |
| US-7465746-B2 | Fluorinated 2,4-diaryl-2,5-dihydropyrrole inhibitors of the mitotic kinesin KSP | MERCK & CO., INC. (US) | 2008-12-16 | — | — | US | disclosed |
| US-20080207693-A1 | Mitotic Kinesin Inhibitors | MERCK SHARP & DOHME CORP. | 2008-08-28 | — | — | US | disclosed |
| EP-1861097-A1 | MITOTIC KINESIN INHIBITORS | Merck & Co., Inc. (US) | 2007-12-05 | — | — | EP | disclosed |
| US-20070225499-A1 | Process for the Preparation of 2,2-Disubstituted Pyrroles | MERCK & CO., INC. | 2007-09-27 | — | — | US | disclosed |
| EP-1740537-A2 | A PROCESS FOR THE PREPARATION OF 2,2-DISUBSTITUTED PYRROLES | Merck & Co., Inc. (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2006101780-A1 | MITOTIC KINESIN INHIBITORS | MERCK & CO., INC. (US) | 2006-09-28 | — | — | WO | disclosed |
| WO-2005102996-A2 | A PROCESS FOR THE PREPARATION OF 2,2-DISUBSTITUTED PYRROLES | MERCK & CO., INC. (US) | 2005-11-03 | — | — | WO | disclosed |
| US-20050043357-A1 | Mitotic kinesin inhibitors | MERCK SHARP & DOHME CORP. | 2005-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225499-A1 | Process for the Preparation of 2,2-Disubstituted Pyrroles | KIF5B, KIF5A, KIF5C | ALDH1A1 1475/4885TSHR 4735/4885KMT2A 491/4885 |
| US-20050043357-A1 | Mitotic kinesin inhibitors | KIF5B, KIF2C, KIF18B | ALDH1A1 2302/4885TSHR 4772/4885KMT2A 431/4885 |
| US-20080207693-A1 | Mitotic Kinesin Inhibitors | KIF5B, KIF2C, KIF23 | ALDH1A1 2547/4885TSHR 4793/4885KMT2A 478/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.