Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGA4 | P13612 | 8/20 | 0.40 |
| ▸ | ITGB7 | P26010 | 8/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGAV | P06756 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.38 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.38 |
| ▸ | BCL2 | P10415 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP3 | P08254 | 1/20 | 0.37 |
| ▸ | MMP7 | P09237 | 1/20 | 0.37 |
| ▸ | MMP9 | P14780 | 1/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | KCNQ1 | P51787 | 2/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4046036 | 0.94 | P2RX7 (0.36) | ITGA4ITGB7BCL2ITGB1CTSK | |
| SCHEMBL4041901 | 0.93 | P2RX7 (0.39) | ITGA4ITGB7ITGB1CTSK | |
| SCHEMBL4045552 | 0.90 | ITGB3 (0.37) | ITGA4ITGB7ITGB3ITGAVBCL2 | |
| SCHEMBL4043833 | 0.89 | F10 (0.36) | ITGA4ITGB7F2F10PLG | |
| SCHEMBL4044695 | 0.88 | CTSK (0.36) | MMP1MMP3MMP7MMP9MMP13 | |
| SCHEMBL4048167 | 0.85 | CTSK (0.50) | F2F10PLGST14KMT2A | |
| SCHEMBL4047239 | 0.84 | CTSK (0.34) | CTSK | |
| SCHEMBL4047305 | 0.83 | P2RX7 (0.37) | ITGA4ITGB7ITGB1CTSK | |
| SCHEMBL4045924 | 0.83 | USP30 (0.40) | ITGA4ITGB7ITGB3ITGAVITGB1 | |
| SCHEMBL4051785 | 0.83 | ITGA4 (0.39) | ITGA4ITGB7ITGB3ITGAVMMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |