Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | GPR132 | Q9UNW8 | 2/20 | 0.38 |
| ▸ | MC4R | P32245 | 1/20 | 0.37 |
| ▸ | MC3R | P41968 | 1/20 | 0.37 |
| ▸ | MC1R | Q01726 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.36 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.35 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | ACE | P12821 | 1/20 | 0.35 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.35 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4047615 | 0.94 | CTSB (0.38) | GPR132TAAR1CTSBCTSSCTSK | |
| SCHEMBL4045511 | 0.93 | F2 (0.38) | CTSBCTSSCTSKF2ITGA4 | |
| SCHEMBL4041436 | 0.91 | ALDH1A1 (0.39) | SCN9AGPR132MC4RMC3RMC1R | |
| SCHEMBL4044160 | 0.90 | CTSB (0.37) | SCN9AGPR132TAAR1CTSBCTSS | |
| SCHEMBL4043952 | 0.89 | CTSK (0.42) | CTSBCTSSCTSKFKBP1ACHRNA7 | |
| SCHEMBL4043465 | 0.89 | MC4R (0.41) | SCN9AGPR132MC4RMC3RMC1R | |
| SCHEMBL4049324 | 0.89 | MC4R (0.37) | SCN9AMC4RMC3RMC1RCTSK | |
| SCHEMBL4043998 | 0.89 | FKBP1A (0.37) | CTSBCTSSCTSKFKBP1ACHRNA7 | |
| SCHEMBL4040214 | 0.87 | GPR132 (0.39) | SCN9AGPR132MC4RMC3RMC1R | |
| SCHEMBL4046868 | 0.84 | ITGB1 (0.37) | GPR132CTSBCTSSCTSKP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |