Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | BMP1 | P13497 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | EDNRB | P24530 | 1/20 | 0.32 |
| ▸ | EDNRA | P25101 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4047459 | 0.93 | CTSK (0.38) | ALDH1A1TSHRHPGDKCNQ1TAS1R3 | |
| SCHEMBL4050306 | 0.89 | PKM (0.36) | ALDH1A1TSHRHPGDKCNQ1TAS1R3 | |
| SCHEMBL4045249 | 0.89 | CTSK (0.36) | HPGDLMNA | |
| SCHEMBL4050093 | 0.89 | HTT (0.41) | ALDH1A1TSHRHPGDKCNQ1TAS1R3 | |
| SCHEMBL6232865 | 0.88 | TAS1R3 (0.46) | ALDH1A1TSHRTAS1R3TAS1R1MAPT | |
| SCHEMBL4044695 | 0.88 | CTSK (0.36) | — | |
| SCHEMBL4048544 | 0.86 | P2RY12 (0.32) | — | |
| SCHEMBL4051941 | 0.85 | ELOVL6 (0.38) | TSHRLMNASMN1; SMN2 | |
| SCHEMBL4043292 | 0.85 | ALDH1A1 (0.37) | ALDH1A1CHRM5MAPTLMNA | |
| SCHEMBL4047785 | 0.85 | CTSK (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546150-B1 | PYRROLE DERIVATIVES AS INHIBITORS OF CYTEINE PROTEASES | AMURA THERAPEUTICS LTD (GB) | 2009-03-04 | — | — | EP | claimed |