Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | GMNN | O75496 | 1/20 | 0.51 |
| ▸ | DRD1 | P21728 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | CCR2 | P41597 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15299574 | 0.86 | RORC (0.40) | ALDH1A1LMNAHPGDMAPTKMT2A | |
| SCHEMBL7967599 | 0.81 | MMP1 (0.47) | MAPTCA1CA2LGMN | |
| SCHEMBL4074745 | 0.79 | ENPP2 (0.45) | SMN1; SMN2TP53 | |
| SCHEMBL1169954 | 0.79 | ALDH1A1 (0.55) | ALDH1A1LMNAHPGDMAPTKMT2A | |
| SCHEMBL9906397 | 0.78 | ALDH1A1 (0.59) | ALDH1A1LMNAHPGDMAPTKMT2A | |
| SCHEMBL3256579 | 0.78 | ALDH1A1 (0.59) | ALDH1A1LMNAHPGDMAPTKMT2A | |
| SCHEMBL3247012 | 0.76 | ALDH1A1 (0.50) | ALDH1A1KMT2ANPC1MEN1CYP3A4 | |
| SCHEMBL7118736 | 0.76 | CA2 (0.52) | ALDH1A1HPGDMAPTKMT2ATDP1 | |
| SCHEMBL4079205 | 0.75 | F2 (0.41) | MAPTTP53CA1CA2 | |
| SCHEMBL22057007 | 0.75 | MAPT (0.53) | ALDH1A1MAPTCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE30303-E | 1-AMINO-4-CYANO-1,3-BUTADIENE COMPOUNDS | EASTMAN KODAK COMPANY (US) | 1980-06-10 | — | — | US | claimed |
| US-10947203-B2 | 1,4,5-substituted 1,2,3-triazole analogues as antagonists of the pregnane X receptor | ST. JUDE CHILDREN'S RSEARCH HOSPITAL (US) | 2021-03-16 | — | — | US | disclosed |
| US-10947203-B2 | 1,4,5-substituted 1,2,3-triazole analogues as antagonists of the pregnane X receptor | ST. JUDE CHILDREN'S RSEARCH HOSPITAL (US) | 2021-03-16 | — | — | US | disclosed |
| US-20200071281-A1 | 1,4,5-SUBSTITUTED 1,2,3-TRIAZOLE ANALOGUES AS ANTAGONISTS OF THE PREGNANE X RECEPTOR | ST JUDE CHILDREN?S RES HOSPITAL (US) | 2020-03-05 | — | — | US | disclosed |
| US-20200071281-A1 | 1,4,5-SUBSTITUTED 1,2,3-TRIAZOLE ANALOGUES AS ANTAGONISTS OF THE PREGNANE X RECEPTOR | ST JUDE CHILDREN?S RES HOSPITAL (US) | 2020-03-05 | — | — | US | disclosed |
| US-10550091-B2 | 1,4,5-substituted 1,2,3-triazole analogues as antagonists of the pregnane X receptor | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2020-02-04 | — | — | US | disclosed |
| US-10550091-B2 | 1,4,5-substituted 1,2,3-triazole analogues as antagonists of the pregnane X receptor | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2020-02-04 | — | — | US | disclosed |
| US-20190077770-A1 | 1,4,5-SUBSTITUTED 1,2,3-TRIAZOLE ANALOGUES AS ANTAGONISTS OF THE PREGNANE X RECEPTOR | ST. JUDE CHILDREN'S RSEARCH HOSPITAL | 2019-03-14 | — | — | US | disclosed |
| US-20190077770-A1 | 1,4,5-SUBSTITUTED 1,2,3-TRIAZOLE ANALOGUES AS ANTAGONISTS OF THE PREGNANE X RECEPTOR | ST. JUDE CHILDREN'S RSEARCH HOSPITAL | 2019-03-14 | — | — | US | disclosed |
| WO-2017165139-A1 | 1,4,5-SUBSTITUTED 1,2,3-TRIAZOLE ANALOGUES AS ANTAGONISTS OF THE PREGNANE X RECEPTOR | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2017-09-28 | — | — | WO | disclosed |
| US-20060128662-A1 | Novel compounds for treatment of obesity | NOVO NORDISK A/S (DK) | 2006-06-15 | — | — | US | disclosed |
| EP-1625112-A1 | NOVEL COMPOUNDS FOR TREATMENT OF OBESITY | NOVO NORDISK A/S (DK) | 2006-02-15 | — | — | EP | disclosed |
| US-6875771-B2 | Pyridopyrimidine derivatives as 5-HT6 antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-04-05 | — | — | US | disclosed |
| WO-2004101505-A1 | NOVEL COMPOUNDS FOR TREATMENT OF OBESITY | NOVO NORDISK A/S (DK) | 2004-11-25 | — | — | WO | disclosed |
| US-20040019064-A1 | Pyridopyrimidine derivatives as 5-HT6 antagonists | WU YONG-JIN (US) | 2004-01-29 | — | — | US | disclosed |
| EP-0941994-B1 | Pyrazolopyrimidines and pyrazolotriazines with 5-HT6 receptor affinity | HOFFMANN LA ROCHE (CH) | 2003-05-14 | — | — | EP | disclosed |
| US-6194410-B1 | ANTISEROTONINE AGENTS; NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS | HOFFMAN-LA ROCHE INC. | 2001-02-27 | — | — | US | disclosed |
| EP-0941994-A1 | Pyrazolopyrimidines and pyrazolotriazines with 5-HT6 receptor affinity | F. HOFFMANN-LA ROCHE AG (CH) | 1999-09-15 | — | — | EP | disclosed |
| US-4172944-A | Water insoluble styryl dyestuffs having hetero-aryl methylene substituent | BAYER AKTIENGESELLSCHAFT (DE) | 1979-10-30 | — | — | US | disclosed |
| US-4016191-A | WATER INSOLUBLE; LIGHTFASTNESS | BAYER AKTIENGESELLSCHAFT (DT) | 1977-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10550091-B2 | 1,4,5-substituted 1,2,3-triazole analogues as antagonists of the pregnane X receptor | NR5A1, CYP11B1, CYP3A5 | ALDH1A1 2290/4885LMNA 4444/4885HPGD 896/4885 |
| US-20200071281-A1 | 1,4,5-SUBSTITUTED 1,2,3-TRIAZOLE ANALOGUES AS ANTAGONISTS OF THE PREGNANE X RECEPTOR | NR5A1, CYP11B1, CYP3A5 | ALDH1A1 2290/4885LMNA 4444/4885HPGD 896/4885 |
| US-10947203-B2 | 1,4,5-substituted 1,2,3-triazole analogues as antagonists of the pregnane X receptor | NR5A1, CYP11B1, CYP3A5 | ALDH1A1 1881/4885LMNA 4350/4885HPGD 703/4885 |
| US-20040019064-A1 | Pyridopyrimidine derivatives as 5-HT6 antagonists | HTR6, HTR4, HTR1A | ALDH1A1 3386/4885LMNA 3345/4885HPGD 1330/4885 |
| US-20190077770-A1 | 1,4,5-SUBSTITUTED 1,2,3-TRIAZOLE ANALOGUES AS ANTAGONISTS OF THE PREGNANE X RECEPTOR | NR5A1, CYP11B1, CYP3A5 | ALDH1A1 2290/4885LMNA 4444/4885HPGD 896/4885 |
| US-20060128662-A1 | Novel compounds for treatment of obesity | GPR119, FABP4, HSD17B4 | ALDH1A1 66/4885LMNA 3584/4885HPGD 692/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.