Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Potassium Ion SCHEMBL861280 | 0.81 | ADORA3 (0.34) | ADORA1ADORA3ADORA2ADDAH1 | |
| SCHEMBL829468 | 0.79 | TP53 (0.36) | TP53L3MBTL1ADORA1ADORA3ADORA2A | |
| SCHEMBL4361446 | 0.79 | TP53 (0.36) | TP53L3MBTL1ADORA1ADORA3ADORA2A | |
| SCHEMBL8901944 | 0.76 | TP53 (0.34) | TP53L3MBTL1ADORA1ADORA3ADORA2A | |
| SCHEMBL11051317 | 0.73 | TP53 (0.40) | TP53L3MBTL1ADORA1ADORA3ADORA2A | |
| SCHEMBL2778487 | 0.73 | TP53 (0.44) | TP53L3MBTL1ADORA1ADORA3ADORA2A | |
| SCHEMBL11062331 | 0.72 | ALDH1A1 (0.32) | L3MBTL1 | |
| SCHEMBL3027865 | 0.69 | ALDH1A1 (0.50) | L3MBTL1 | |
| SCHEMBL4607159 | 0.69 | LMNA (0.41) | TP53L3MBTL1 | |
| SCHEMBL2020536 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090104463-A1 | Gold alloy electrolytes | ROHM AND HAAS ELECTRONIC MATERIALS LLC | 2009-04-23 | — | — | US | disclosed |
| EP-0069443-B1 | IMIDAZOLES, THEIR PRODUCTION AND THEIR USE IN PREVENTING CORROSION OF SILVER | SHIKOKU CHEMICALS CORPORATION (JP) | 1984-11-07 | — | — | EP | disclosed |
| US-4469622-A | Method for preventing rusting in silver by using novel imidazole-4(5)-dithiocarboxylic acids in organic solvent | SHIKOKU CHEMICALS CORPORATION (JP) | 1984-09-04 | — | — | US | disclosed |
| US-4394511-A | Imidazole 4(5)-dithiocarboxylic acids or salts | SHIKOKU CHEMICALS CORPORATION (JP) | 1983-07-19 | — | — | US | disclosed |