Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Phenobarbital. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 6/20 | 0.48 |
| ▸ | MMP9 | P14780 | 6/20 | 0.48 |
| ▸ | MMP3 | P08254 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | MMP13 | P45452 | 2/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenobarbital SCHEMBL11114624 | 0.80 | KMT2A (0.51) | KMT2ALMNATSHRMEN1CYP1A2 | |
| Phenobarbital SCHEMBL5697134 | 0.80 | LMNA (0.42) | KMT2ALMNATSHRMEN1CYP1A2 | |
| Phenobarbital SCHEMBL7945220 | 0.78 | CYP3A4 (0.49) | KMT2ALMNATSHRMEN1CYP1A2 | |
| Phenobarbital SCHEMBL27833760 | 0.74 | MMP2 (0.75) | KMT2ALMNATSHRMEN1CYP1A2 | |
| Secobarbital SCHEMBL8446502 | 0.73 | MMP9 (0.53) | KMT2ALMNATSHRMEN1CYP1A2 | |
| Phenobarbital SCHEMBL28099657 | 0.73 | MMP2 (0.80) | KMT2ALMNATSHRMEN1CYP1A2 | |
| Phenobarbital SCHEMBL16583 | 0.73 | MMP2 (0.80) | KMT2ALMNATSHRMEN1CYP1A2 | |
| Phenobarbital SCHEMBL18825042 | 0.73 | MMP2 (0.80) | KMT2ALMNATSHRMEN1CYP1A2 | |
| Phenobarbital SCHEMBL2592325 | 0.73 | MMP2 (0.80) | KMT2ALMNATSHRMEN1CYP1A2 | |
| Phenobarbital SCHEMBL3475428 | 0.72 | MMP2 (0.77) | KMT2ALMNATSHRMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 3256 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12636254-B2 | Stabilization of phenobarbital sodium for injection | SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED (IN) | 2026-05-26 | — | — | US | claimed |
| CN-119738394-A | Method for rapidly detecting phenobarbital by using dynamic SERS | 内蒙古民族大学 | 2025-04-01 | — | — | CN | claimed |
| CN-119236172-A | Injection filler and preparation method and application thereof | 渼颜空间生物科技(吉林)有限公司 | 2025-01-03 | — | — | CN | claimed |
| CN-118726235-A | Artificial liver model for acute liver injury and construction method and application thereof | 中国医学科学院生物医学工程研究所 | 2024-10-01 | — | — | CN | claimed |
| US-20240316049-A1 | STABILIZATION OF PHENOBARBITAL SODIUM FOR INJECTION | SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED (IN) | 2024-09-26 | — | — | US | claimed |
| US-20240282425-A1 | AUTHENTICATION METHODS AND SYSTEMS FOR DISPENSED PRESCRIPTIONS | LOW GORDON KEITH (US) | 2024-08-22 | — | — | US | claimed |
| US-20240082161-A1 | STABILIZATION OF PHENOBARBITAL SODIUM FOR INJECTION | SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED (IN) | 2024-03-14 | — | — | US | claimed |
| CN-117481863-A | Method for establishing pulmonary ischemia reperfusion injury mouse model | 扬州大学 | 2024-02-02 | — | — | CN | claimed |
| US-11878076-B2 | Lyophilized compositions of phenobarbital sodium salt | Nivagen Pharmaceuticals, Inc. (US) | 2024-01-23 | — | — | US | claimed |
| US-11857683-B2 | Stabilization of phenobarbital sodium for injection | SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED (IN) | 2024-01-02 | — | — | US | claimed |
| CN-2329059-Y | Quick look-up instrument for incompatibility of drugs in a prescription of 159 kind of injections | GU CHUNWEI (CN) | 1999-07-14 | — | — | CN | claimed |
| WO-1998051282-A1 | SOLID POROUS MATRICES AND METHODS OF MAKING AND USING THE SAME | IMARX PHARMACEUTICAL CORP. (US) | 1998-11-19 | — | — | WO | claimed |
| US-5770222-A | Therapeutic drug delivery systems | IMARX PHARMACEUTICAL CORP. (US) | 1998-06-23 | — | — | US | claimed |
| EP-0716661-A1 | PSEUDO- AND NON-PEPTIDE BRADYKININ RECEPTOR ANTAGONISTS | SCIOS NOVA INC. (US) | 1996-06-19 | — | — | EP | claimed |
| WO-1995007294-A1 | PSEUDO- AND NON-PEPTIDE BRADYKININ RECEPTOR ANTAGONISTS | SCIOS NOVA INC. (US) | 1995-03-16 | — | — | WO | claimed |
| US-5354563-A | Water dispersion containing ultrafine particles of organic compounds | RESEARCH DEVELOPMENT CORP. OF JAPAN (JP) | 1994-10-11 | — | — | US | claimed |
| EP-0209403-B1 | PROCESS FOR PREPARING ULTRAFINE PARTICLES OF ORGANIC COMPOUNDS | Research Development Corporation of Japan (JP) | 1991-10-23 | — | — | EP | claimed |
| US-4913865-A | Process for preparing ultrafine particles of organic compounds | RESEARCH DEVELOPMENT CORP OF JAPAN (JP) | 1990-04-03 | — | — | US | claimed |
| EP-0209403-A2 | Process for preparing ultrafine particles of organic compounds | Research Development Corporation of Japan (JP) | 1987-01-21 | — | — | EP | claimed |
| US-4466953-A | Polymeric diffusion matrix | KEY PHARMACEUTICALS, INC. (US) | 1984-08-21 | — | — | US | claimed |