Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 3/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL36369 | 0.76 | MAP3K14 (0.43) | MAP3K14CRBNDDB1CYP19A1 | |
| SCHEMBL11835120 | 0.76 | MAP3K14 (0.43) | MAP3K14CRBNDDB1CYP19A1 | |
| SCHEMBL11047080 | 0.76 | MAP3K14 (0.43) | MAP3K14CRBNDDB1CYP19A1 | |
| Water SCHEMBL27852712 | 0.74 | MAP3K14 (0.41) | MAP3K14CRBNDDB1CYP19A1 | |
| SCHEMBL4226226 | 0.74 | MAP3K14 (0.41) | MAP3K14CRBNDDB1CYP19A1 | |
| SCHEMBL625564 | 0.72 | MAP3K14 (0.40) | MAP3K14CRBNDDB1CYP19A1 | |
| SCHEMBL18065790 | 0.72 | MAP3K14 (0.40) | MAP3K14CRBNDDB1CYP19A1 | |
| SCHEMBL27082399 | 0.72 | CRBN (0.41) | MAP3K14CRBNDDB1CYP19A1 | |
| SCHEMBL11280494 | 0.68 | MAP3K14 (0.36) | MAP3K14CRBNDDB1 | |
| Malonic Acid SCHEMBL27832197 | 0.66 | ITGB1 (0.35) | MAP3K14CRBNDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115558705-A | Nucleic acid detection chip, preparation method and nucleic acid detection method | 南方科技大学 | 2023-01-03 | — | — | CN | claimed |
| CN-112574089-B | Photo-induced multifunctional crosslinking agent, preparation method and application thereof | 中国科学院上海药物研究所 | 2023-09-05 | — | — | CN | disclosed |
| WO-2022253260-A1 | DETECTION KIT FOR NEUTRALIZING ANTIBODY FOR NOVEL CORONAVIRUS AND MUTANT STRAIN THEREOF | 南京金斯瑞生物科技有限公司 | 2022-12-08 | — | — | WO | disclosed |
| CN-114682220-B | Selective adsorption material for treating thallium and mercury-containing wastewater, preparation method thereof and method for treating thallium and mercury-containing wastewater by using selective adsorption material | 矿冶科技集团有限公司 | 2022-08-23 | — | — | CN | disclosed |
| CN-114682220-A | Selective adsorption material for treating thallium and mercury-containing wastewater, preparation method thereof and method for treating thallium and mercury-containing wastewater by using selective adsorption material | 矿冶科技集团有限公司 | 2022-07-01 | — | — | CN | disclosed |
| CN-113419061-B | Magnetic particle chemiluminescence kit for detecting SARS-CoV-2 virus neutralizing antibody and application thereof | 南京金斯瑞生物科技有限公司 | 2022-02-01 | — | — | CN | disclosed |
| CN-113825772-A | anti-HER 2 affibodies and switchable chimeric antigen receptors using the same as switch molecules | 艾克隆株式会社 | 2021-12-21 | — | — | CN | disclosed |
| WO-2019178990-A1 | SELF-ADHESIVE MICRONEEDLE PATCH CAPABLE OF RAPIDLY SWELLING AND PREPARATION METHOD THEREFOR | 苏州德锐特成像技术有限公司 | 2019-09-26 | — | — | WO | disclosed |
| CN-103834041-B | MGF-Ct24E (Mechano-growth factor-Ct24E) functionalized polylactic acid bionic bone matrix material and preparation method thereof | 重庆医药高等专科学校 | 2017-02-08 | — | — | CN | disclosed |
| CN-103834041-A | MGF-Ct24E (Mechano-growth factor-Ct24E) functionalized polylactic acid bionic bone matrix material and preparation method thereof | CHONGQING MEDICAL & PHARMACEUTICAL COLLEGE | 2014-06-04 | — | — | CN | disclosed |
| WO-2006064451-A2 | TARGETING CONTRAST AGENTS OR TARGETING THERAPEUTIC AGENTS FOR MOLECULAR IMAGING AND THERAPY | KONINKLIJKE PHILIPS ELECTRONICS N.V. (NL) | 2006-06-22 | — | — | WO | disclosed |
| EP-1015428-B1 | SULFO-N-HYDROXY SUCCINIMIDE AND METHOD OF PREPARATION | PIERCE CHEMICAL CO (US) | 2003-05-02 | — | — | EP | disclosed |
| US-6407263-B1 | CHEMICAL INTERMEDIATE FOR SUCCINIMIDE | PIERCE CHEMICAL COMPANY | 2002-06-18 | — | — | US | disclosed |
| EP-1015428-A1 | SULFO-N-HYDROXY SUCCINIMIDE AND METHOD OF PREPARATION | PIERCE CHEMICAL COMPANY (US) | 2000-07-05 | — | — | EP | disclosed |
| CN-1240492-A | PVC-free foamed flooring and wall convering and a method for making the same | DOW CHEMICAL CO (US) | 2000-01-05 | — | — | CN | disclosed |
| US-5942628-A | Method for the preparation of sulfo-N-hydroxy succinimade salts | PIERCE CHEMICAL COMPANY (US) | 1999-08-24 | — | — | US | disclosed |
| US-5892057-A | Preparation of sulfo-N-hydroxysuccinimide salts | PIERCE CHEMICAL COMPANY (US) | 1999-04-06 | — | — | US | disclosed |
| WO-1999014192-A1 | SULFO-N-HYDROXY SUCCINIMIDE AND METHOD OF PREPARATION | PIERCE CHEMICAL COMPANY (US) | 1999-03-25 | — | — | WO | disclosed |
| EP-0843816-A2 | DETERMINATION OF AN ANALYTE IN A LIQUID MEDIUM | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 1998-05-27 | — | — | EP | disclosed |
| WO-1997004314-A2 | DETERMINATION OF AN ANALYTE IN A LIQUID MEDIUM | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) | 1997-02-06 | — | — | WO | disclosed |