Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC10A2 known ✓ | Q12908 | 1/20 | 0.30 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.36 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.36 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3245280 | 1.00 | GNAI3 (0.36) | GNAI3GNAO1GNAI1TSHRTHRB | |
| Hydrochloric Acid SCHEMBL5350258 | 1.00 | GNAI3 (0.36) | GNAI3GNAO1GNAI1TSHRTHRB | |
| SCHEMBL14380155 | 0.98 | TSHR (0.36) | GNAI3GNAO1GNAI1TSHRTHRB | |
| SCHEMBL840549 | 0.98 | TSHR (0.36) | GNAI3GNAO1GNAI1TSHRTHRB | |
| SCHEMBL3239761 | 0.98 | TSHR (0.36) | GNAI3GNAO1GNAI1TSHRTHRB | |
| SCHEMBL841580 | 0.98 | TSHR (0.36) | GNAI3GNAO1GNAI1TSHRTHRB | |
| SCHEMBL4062252 | 0.98 | TSHR (0.36) | GNAI3GNAO1GNAI1TSHRTHRB | |
| SCHEMBL4058133 | 0.98 | TSHR (0.36) | GNAI3GNAO1GNAI1TSHRTHRB | |
| SCHEMBL4067401 | 0.98 | TSHR (0.36) | GNAI3GNAO1GNAI1TSHRTHRB | |
| SCHEMBL4059880 | 0.98 | TSHR (0.36) | GNAI3GNAO1GNAI1TSHRTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090233935-A1 | Methods for Fabrication of Antimicrobial Surfaces | RESEARCH FOUNDATION OF CITY UNIVERSITY OF NEW YORK (US) | 2009-09-17 | — | — | US | disclosed |
| EP-1945229-A2 | METHODS FOR FABRICATION OF ANTIMICROBIAL SURFACES | Research Foundation of the City University of New York (US) | 2008-07-23 | — | — | EP | disclosed |
| WO-2008018890-A2 | METHODS FOR FABRICATION OF ANTIMICROBIAL SURFACES | RESEARCH FOUNDATION OF CITY UNIVERSITY OF NEW YORK (US) | 2008-02-14 | — | — | WO | disclosed |
| US-7285286-B2 | Antimicrobial surfaces | LONG ISLAND UNIVERSITY (US) | 2007-10-23 | — | — | US | disclosed |
| US-7241453-B2 | Antimicrobial surfaces | LONG ISLAND UNIVERSITY (US) | 2007-07-10 | — | — | US | disclosed |
| US-20060199758-A1 | ANTIMICROBIAL SURFACES | ENGEL ROBERT | 2006-09-07 | — | — | US | disclosed |
| US-20050181006-A1 | Antimicrobial surfaces | PACE UNIVERSITY | 2005-08-18 | — | — | US | disclosed |
| EP-1496823-A2 | ANTIMICROBIAL SURFACES | Research Foundation of the City University of New York (US) | 2005-01-19 | — | — | EP | disclosed |
| WO-2003086477-A2 | ANTIMICROBIAL SURFACES | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (US) | 2003-10-23 | — | — | WO | disclosed |
| US-4079014-A | Electrographic toner and developer composition containing a 4-aza-1-azoniabicyclo(2.2.2) octane salt as a charge control agent | EASTMAN KODAK COMPANY (US) | 1978-03-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060199758-A1 | ANTIMICROBIAL SURFACES | TLR2, NR0B2, FPR2 | SLC10A2 1561/4885GNAI3 4050/4885GNAO1 3308/4885 |
| US-20090233935-A1 | Methods for Fabrication of Antimicrobial Surfaces | ADH1A, ADH1C, HAO2 | SLC10A2 1951/4885GNAI3 3356/4885GNAO1 3769/4885 |
| US-20050181006-A1 | Antimicrobial surfaces | QSOX1, LBR, FPR1 | SLC10A2 3292/4885GNAI3 3460/4885GNAO1 3227/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.