Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | TLR4 | O00206 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1743259 | 0.78 | TLR4 (0.32) | TLR4 | |
| SCHEMBL13242146 | 0.78 | CRBN (0.37) | CRBN | |
| SCHEMBL7965133 | 0.76 | ALDH1A1 (0.38) | CRBNTLR4 | |
| SCHEMBL20707223 | 0.76 | MAPT (0.38) | — | |
| SCHEMBL10348490 | 0.76 | MAPT (0.38) | — | |
| SCHEMBL9333656 | 0.75 | — | — | |
| SCHEMBL1766113 | 0.75 | NPSR1 (0.35) | NPSR1 | |
| SCHEMBL14867426 | 0.75 | HCAR2 (0.35) | NPSR1 | |
| SCHEMBL10591889 | 0.75 | ALDH1A1 (0.35) | CRBNTLR4 | |
| SCHEMBL15328544 | 0.74 | NPSR1 (0.38) | NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8846747-B2 | Compounds and methods for altering lifespan of eukaryotic organisms | UNIVERSITY OF ROCHESTER (US) | 2014-09-30 | — | — | US | claimed |
| EP-2838881-B1 | ISOINDOLONE DERIVATIVES | ABBVIE INC (US) | 2018-08-08 | — | — | EP | disclosed |
| US-9776990-B2 | Isoindolone derivatives | ABBVIE INC. (US) | 2017-10-03 | — | — | US | disclosed |
| US-20150111890-A1 | ISOINDOLONE DERIVATIVES | ABBVIE INC. | 2015-04-23 | — | — | US | disclosed |
| EP-2850071-A1 | ISOINDOLONE DERIVATIVES | AbbVie Inc. (US) | 2015-03-25 | — | — | EP | disclosed |
| EP-2838881-A1 | ISOINDOLONE DERIVATIVES | AbbVie Inc. (US) | 2015-02-25 | — | — | EP | disclosed |
| US-8846747-B2 | Compounds and methods for altering lifespan of eukaryotic organisms | UNIVERSITY OF ROCHESTER (US) | 2014-09-30 | — | — | US | disclosed |
| US-8846747-B2 | Compounds and methods for altering lifespan of eukaryotic organisms | UNIVERSITY OF ROCHESTER (US) | 2014-09-30 | — | — | US | disclosed |
| US-8642660-B2 | Method for altering the lifespan of eukaryotic organisms | THE UNIVERSITY OF ROCHESTER (US) | 2014-02-04 | — | — | US | disclosed |
| US-20130281450-A1 | ISOINDOLONE DERIVATIVES | ABBVIE INC. | 2013-10-24 | — | — | US | disclosed |
| WO-2011062964-A1 | COMPOUNDS AND METHODS FOR ALTERING LIFESPAN OF EUKARYOTIC ORGANISMS | UNIVERSITY OF ROCHESTER (US) | 2011-05-26 | — | — | WO | disclosed |
| US-20100192250-A1 | Use of Fungicides for Making the Phenological Development of Oil Plants More Coherent | BASF SE (DE) | 2010-07-29 | — | — | US | disclosed |
| US-7686975-B2 | Use of acylcyclohexanedione derivatives for improving the tolerance of plants to cold and/or frost | BASF AKTIENGESELLSCHAFT (DE) | 2010-03-30 | — | — | US | disclosed |
| US-20090270435-A1 | Spiroketone Acetyl-CoA Carboxylase Inhibitors | CORBETT JEFFREY WAYNE | 2009-10-29 | — | — | US | disclosed |
| EP-2097420-A1 | SPIROKETONE ACETYL-COA CARBOXYLASE INHIBITORS | Pfizer Products Inc. (US) | 2009-09-09 | — | — | EP | disclosed |
| US-20090163545-A1 | Method For Altering The Lifespan Of Eukaryotic Organisms | UNIVERSITY OF ROCHESTER (US) | 2009-06-25 | — | — | US | disclosed |
| WO-2008065508-A1 | SPIROKETONE ACETYL-COA CARBOXYLASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 2008-06-05 | — | — | WO | disclosed |
| US-20070066485-A1 | Use of acylcyclohexanedione derivatives for improving the tolerance of plants to cold and/or frost | BASF AKTIENGESELLSCHAFT (DE) | 2007-03-22 | — | — | US | disclosed |
| US-6215016-B1 | HEMATOPOIETIC AGENTS; PREVENTING CYTOPENIA | TORAY INDUSTRIES, INC. (JP) | 2001-04-10 | — | — | US | disclosed |
| EP-0841063-A1 | KETONE DERIVATIVES AND MEDICINAL USE THEREOF | TORAY INDUSTRIES, INC. (JP) | 1998-05-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100192250-A1 | Use of Fungicides for Making the Phenological Development of Oil Plants More Coherent | CYP4Z1, CYP4X1, CYP51A1 | CRBN 660/4885TLR4 4738/4885NPSR1 4594/4885 |
| US-20150111890-A1 | ISOINDOLONE DERIVATIVES | CYP11B1, HSD17B7, CYP4A11 | CRBN 4483/4885TLR4 1920/4885NPSR1 993/4885 |
| US-20070066485-A1 | Use of acylcyclohexanedione derivatives for improving the tolerance of plants to cold and/or frost | ACACB, FADS1, ACAT1 | CRBN 4473/4885TLR4 3010/4885NPSR1 4294/4885 |
| US-20090163545-A1 | Method For Altering The Lifespan Of Eukaryotic Organisms | TUFM, MRM1, HOGA1 | CRBN 3758/4885TLR4 3880/4885NPSR1 4078/4885 |
| US-20090270435-A1 | Spiroketone Acetyl-CoA Carboxylase Inhibitors | ACACA, PC, ACACB | CRBN 3675/4885TLR4 2388/4885NPSR1 2555/4885 |
| US-20130281450-A1 | ISOINDOLONE DERIVATIVES | CYP11B1, HSD17B7, CYP4A11 | CRBN 4470/4885TLR4 1885/4885NPSR1 999/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.