Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | AGXT | P21549 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13389323 | 0.79 | TP53 (0.43) | CYP2A6TAAR1TDP1TP53ALDH1A1 | |
| SCHEMBL436889 | 0.75 | CYP1A2 (0.50) | IDO1CYP1A2CYP2A6TAAR1ACHE | |
| SCHEMBL13389464 | 0.75 | LPL (0.45) | MAPTALDH1A1POLBCA2KDM4E | |
| SCHEMBL10250538 | 0.74 | IDO1 (0.46) | IDO1CYP1A2CYP2A6TAAR1AGXT | |
| SCHEMBL13389477 | 0.74 | ESR1 (0.50) | IDO1TAAR1TDP1MAPTALDH1A1 | |
| SCHEMBL436783 | 0.74 | IDO1 (0.46) | IDO1TAAR1AGXTCHRM2LMNA | |
| SCHEMBL438568 | 0.73 | TSHR (0.42) | ACHETP53CA1CA2LMNA | |
| SCHEMBL13389468 | 0.73 | PTGS1 (0.42) | MAPTALDH1A1POLBLMNAMEN1 | |
| SCHEMBL13325730 | 0.73 | ALDH1A1 (0.56) | TDP1MAPTTP53ALDH1A1MEN1 | |
| SCHEMBL438658 | 0.73 | IDO1 (0.52) | IDO1CYP1A2TAAR1AGXTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022056042-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2022-03-17 | — | — | WO | disclosed |
| EP-3512556-B1 | COMBINED TREATMENT WITH A TLR7 AGONIST AND AN HBV CAPSID ASSEMBLY INHIBITOR | HOFFMANN LA ROCHE (CH) | 2021-08-18 | — | — | EP | disclosed |
| WO-2020231333-A1 | TYROSINASE INHIBITORS AND THEIR USES | NATIONAL UNIVERSITY OF SINGAPORE (SG) | 2020-11-19 | — | — | WO | disclosed |
| US-10035799-B2 | COMT inhibiting methods and compositions | LIEBER INSTITUTE FOR BRAIN DEVELOPMENT (US) | 2018-07-31 | — | — | US | disclosed |
| US-20160222011-A1 | COMT Inhibiting Methods and Compositions | LIEBER INSTITUTE, INC. | 2016-08-04 | — | — | US | disclosed |
| US-9144573-B2 | Prostaglandin transporter inhibitors | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2015-09-29 | — | — | US | disclosed |
| US-20150073136-A1 | PYRAZINONE DERIVATIVES | ASTRAZENECA AB (SE) | 2015-03-12 | — | — | US | disclosed |
| US-8889692-B2 | Pyrazinone derivatives, pharmaceutically acceptance salts thereof and their uses | ASTRAZENECA AB (SE) | 2014-11-18 | — | — | US | disclosed |
| US-8772327-B2 | Phenylpropionic acid derivative and use thereof | ASAHI KASEI PHARMA CORPORATION (JP) | 2014-07-08 | — | — | US | disclosed |
| EP-2684881-A1 | COMPOUND HAVING FLUORESCENT CHROMOPHORE, ION CONCENTRATION SENSOR INCLUDING COMPOUND, REAGENT INCLUDING COMPOUND, REAGENT KIT PROVIDED WITH REAGENT, PRECURSOR OF COMPOUND, AND METHOD FOR SYNTHESIZING COMPOUND | National University Corporation Hokkaido University (JP) | 2014-01-15 | — | — | EP | disclosed |
| US-7771962-B2 | CD10-activated prodrug compounds | MEDAREX, INC. (US) | 2010-08-10 | — | — | US | disclosed |
| US-20090270647-A1 | METHOD FOR PRODUCING ALPHA - AMINO ACID INCLUDING PHOSPHORUS AND PRODUCTION INTERMEDIATES THEREOF | MEIJI SEIKA KAISHA LTD. (JP) | 2009-10-29 | — | — | US | disclosed |
| US-20090215712-A1 | PYRAZOLE DERIVATIVES | PFIZER INC | 2009-08-27 | — | — | US | disclosed |
| US-20090143358-A1 | INHIBITORS OF ION CHANNELS | ICAGEN, INC. (US) | 2009-06-04 | — | — | US | disclosed |
| US-20090136980-A1 | CD10-activated prodrug compounds | MEDAREX, INC. (US) | 2009-05-28 | — | — | US | disclosed |
| US-20090110753-A1 | Enzyme-cleavable prodrug compounds | MEDAREX, INC. (US) | 2009-04-30 | — | — | US | disclosed |
| US-7435728-B2 | Pyrazole derivatives | PFIZER INC (US) | 2008-10-14 | — | — | US | disclosed |
| US-7425541-B2 | Enzyme-cleavable prodrug compounds | MEDAREX, INC. (US) | 2008-09-16 | — | — | US | disclosed |
| US-20070275903-A1 | Tripeptide prodrug compounds | MEDAREX, INC. (US) | 2007-11-29 | — | — | US | disclosed |
| US-7214663-B2 | Tripeptide prodrug compounds | MEDAREX, INC. (US) | 2007-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215712-A1 | PYRAZOLE DERIVATIVES | RRM2B, REV1, RRM2 | IDO1 578/4885CYP1A2 348/4885CYP2A6 1296/4885 |
| US-20090270647-A1 | METHOD FOR PRODUCING ALPHA - AMINO ACID INCLUDING PHOSPHORUS AND PRODUCTION INTERMEDIATES THEREOF | BCAT1, BCAT2, DAO | IDO1 615/4885CYP1A2 426/4885CYP2A6 177/4885 |
| US-10035799-B2 | COMT inhibiting methods and compositions | COMT, SLC6A3, MAOA | IDO1 875/4885CYP1A2 157/4885CYP2A6 144/4885 |
| US-20160222011-A1 | COMT Inhibiting Methods and Compositions | COMT, SLC6A3, MAOA | IDO1 875/4885CYP1A2 157/4885CYP2A6 144/4885 |
| US-20090143358-A1 | INHIBITORS OF ION CHANNELS | TRPV1, TRPV5, TRPA1 | IDO1 2615/4885CYP1A2 2489/4885CYP2A6 1907/4885 |
| US-20150073136-A1 | PYRAZINONE DERIVATIVES | CYP3A7, CYP3A4, CYP2D6 | IDO1 1812/4885CYP1A2 9/4885CYP2A6 115/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.