Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 5/20 | 0.34 |
| ▸ | DRD3 | P35462 | 5/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4880816 | 0.82 | ALDH1A1 (0.44) | ADRB1KDM4EALDH1A1L3MBTL1LMNA | |
| SCHEMBL4113163 | 0.81 | DRD2 (0.51) | DRD2DRD3KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL1897597 | 0.80 | ALDH1A1 (0.47) | KDM4EALDH1A1L3MBTL1LMNAHTT | |
| SCHEMBL4430996 | 0.80 | ALDH1A1 (0.47) | KDM4EALDH1A1L3MBTL1LMNAHTT | |
| SCHEMBL2125041 | 0.77 | MAPT (0.50) | KDM4EALDH1A1LMNAHTT | |
| SCHEMBL27586331 | 0.77 | LGMN (0.40) | ADRB1KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL27769716 | 0.77 | CYP2D6 (0.45) | CHRM1DRD2DRD3KDM4ELMNA | |
| SCHEMBL17838712 | 0.77 | KDM4E (0.41) | DRD2DRD3KDM4EALDH1A1LMNA | |
| SCHEMBL10756068 | 0.77 | DRD4 (0.60) | DRD2DRD3KDM4EALDH1A1PLA2G1B | |
| SCHEMBL10926967 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115028585-A | Arylalkanazole derivatives and use thereof | 聊城大学 | 2022-09-09 | — | — | CN | claimed |
| EP-1581474-B1 | CHIRAL ARYLKETONES IN THE TREATEMENT OF NEUTROPHIL-DEPENDENT INFLAMMATORY DESEASES | DOMPE SPA (IT) | 2008-08-27 | — | — | EP | claimed |
| CN-100383110-C | Chiral arylketones in the treatment of neutrophil-dependent inflammatory diseases | DOMPE SPA (IT) | 2008-04-23 | — | — | CN | claimed |
| CN-100368394-C | N- (2-aryl-propionyl) -sulfonamides and pharmaceutical compositions containing them | DOMPE SPA (IT) | 2008-02-13 | — | — | CN | claimed |
| US-20060247297-A1 | Chiral arylketones in the treatment of neutrophil-dependent inflammatory diseases | DOMPE PHA.R.MA S.P.A. (IT) | 2006-11-02 | — | — | US | claimed |
| CN-1732145-A | Chiral arylketones in the treatment of neutrophil-dependent inflammatory diseases | DOMPE SPA (IT) | 2006-02-08 | — | — | CN | claimed |
| EP-1581474-A1 | CHIRAL ARYLKETONES IN THE TREATEMENT OF NEUTROPHIL-DEPENDENT INFLAMMATORY DESEASES | Dompé S.P.A. (IT) | 2005-10-05 | — | — | EP | claimed |
| US-6887903-B1 | N-(2-aryl-propionyl)-sulfonamides and pharmaceutical preparations containing them | DOMPE S.P.A. (IT) | 2005-05-03 | — | — | US | claimed |
| WO-2004052830-A1 | CHIRAL ARYLKETONES IN THE TREATEMENT OF NEUTROPHIL-DEPENDENT INFLAMMATORY DESEASES | DOMPE S.P.A. (IT) | 2004-06-24 | — | — | WO | claimed |
| US-6683205-B2 | FROM ARYLCARBOXYALDEHYDES OR 2-ARYL-3-HYDROXYPROPENOIC ACIDS | WISYS TECHNOLOGY FOUNDATION, INC. | 2004-01-27 | — | — | US | claimed |
| US-20030216392-A1 | N - ( 2 - aryl - propionyl ) - sulfonamides and pharmaceutical preparations containing them | DOMPE S.P.A. | 2003-11-20 | — | — | US | claimed |
| EP-1123276-B1 | N-(2-ARYL-PROPIONYL)-SULFONAMIDES AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | DOMPE SPA (IT) | 2003-01-08 | — | — | EP | claimed |
| US-20020120153-A1 | Synthesis of 2-aryl propenoic acid esters for the production of non-steroidal anti-inflammatory drugs | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2002-08-29 | — | — | US | claimed |
| EP-0991793-B1 | METHOD FOR PREPARING 2-ARYL OR 2-HETEROCYCLYL CHIRAL PROPIONIC ACIDS AND THEIR ESTERS | CT NAT DE BR LA RECH SCIENT (FR) | 2001-12-05 | — | — | EP | claimed |
| US-6294069-B1 | MIXTURE OF PROPIONIC ACID DERIVATIVE IS ELECTROCHEMICALLY REDUCED IN THE PRESENCE OF NICKEL COMPLEX CATALYST AND SUPPORTING ELECTROLYTE IN ELECTROLYSIS CELL PROVIDED WITH ELECTRODES, PRODUCT IS HYDROLYZED OR TRANSESTERIFIED | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2001-09-25 | — | — | US | claimed |
| EP-1123276-A1 | N-(2-ARYL-PROPIONYL)-SULFONAMIDES AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | Dompe' S.P.A. (IT) | 2001-08-16 | — | — | EP | claimed |
| WO-2000024710-A1 | N-(2-ARYL-PROPIONYL)-SULFONAMIDES AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | DOMPE' S.P.A. (IT) | 2000-05-04 | — | — | WO | claimed |
| CN-115028585-B | Arylalkylazole derivative and application thereof | 聊城大学 | 2023-08-18 | — | — | CN | disclosed |
| EP-0048136-A2 | Process for preparing alpha-aromatic group substituted alkanoic acids or esters thereof | SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) | 1982-03-24 | — | — | EP | disclosed |
| EP-0024282-A1 | Benzoyl derivatives, their preparation and their use as medicines | Dr. Karl Thomae GmbH (DE) | 1981-03-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030216392-A1 | N - ( 2 - aryl - propionyl ) - sulfonamides and pharmaceutical preparations containing them | ELANE, MPO, FPR1 | CHRM1 2321/4885PTGS1 29/4885DRD2 2754/4885 |
| US-20060247297-A1 | Chiral arylketones in the treatment of neutrophil-dependent inflammatory diseases | NR1H4, MMP8, NR1I2 | CHRM1 3769/4885PTGS1 664/4885DRD2 2787/4885 |
| US-20020120153-A1 | Synthesis of 2-aryl propenoic acid esters for the production of non-steroidal anti-inflammatory drugs | ALOX15, ALOX15B, ALOX5 | CHRM1 2539/4885PTGS1 14/4885DRD2 915/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.