Sugi Predict

Sugi Predict / Compounds / SCHEMBL4485832

SCHEMBL4485832

SCHEMBL4485832

O=C(NS(=O)(=O)c1ccc(NC(=O)C2CC2)cc1)c1ccccc1Cl

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ FLT1 P17948 3/20 0.65
▸ FLT4 P35916 3/20 0.65
▸ KDR P35968 3/20 0.65
▸ TP53 P04637 2/20 0.57
▸ GAA P10253 2/20 0.57
▸ LMNA P02545 1/20 0.57
▸ TSHR P16473 1/20 0.57
▸ PTBP1 P26599 1/20 0.57
▸ SMN1; SMN2 Q16637 1/20 0.57
▸ KMT2A Q03164 3/20 0.55
▸ POLB P06746 1/20 0.54
▸ RXFP1 Q9HBX9 1/20 0.53
▸ MAPT P10636 2/20 0.51
▸ MEN1 O00255 2/20 0.50
▸ L3MBTL1 Q9Y468 1/20 0.50
▸ NR2E3 Q9Y5X4 1/20 0.49
▸ CA1 P00915 1/20 0.49
▸ CA2 P00918 1/20 0.49
▸ CA9 Q16790 1/20 0.49
▸ GFER P55789 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4476646 0.84 FLT1 (0.72) FLT1FLT4KDRTP53GAA
SCHEMBL4468235 0.83 MAPT (0.61) GAAKMT2APOLBRXFP1MAPT
SCHEMBL4484204 0.83 RBP4 (0.49) FLT1FLT4KDRGAALMNA
SCHEMBL4477116 0.81 LIPE (0.50) TP53LMNASMN1; SMN2KMT2ARXFP1
SCHEMBL31060566 0.80 FLT1 (1.00) FLT1FLT4KDRL3MBTL1
SCHEMBL11442730 0.79 FLT1 (0.82) FLT1FLT4KDRPOLBMAPT
SCHEMBL7798059 0.79 MEN1 (0.60) LMNASMN1; SMN2KMT2APOLBRXFP1
SCHEMBL4463018 0.79 MEN1 (0.57) LMNASMN1; SMN2KMT2APOLBRXFP1
SCHEMBL3299759 0.78 FLT1 (0.65) FLT1FLT4KDRLMNASMN1; SMN2
SCHEMBL9659192 0.77 FLT1 (0.78) FLT1FLT4KDRTP53KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8748343-B2 Herbicide/safener combintions BAYER CROPSCIENCE AG (DE) 2014-06-10 — — US disclosed
US-20120322657-A1 HERBICIDE/SAFENER COMBINTIONS ZIEMER FRANK (DE) 2012-12-20 — — US disclosed
US-7605111-B2 Herbicides SYNGENTA CROP PROTECTION, INC. (US) 2009-10-20 — — US disclosed
US-7459414-B2 Herbicides SYNGENTA CROP PROTECTION, INC. (US) 2008-12-02 — — US disclosed
US-20080200336-A1 HERBICIDAL COMPOSITION SYNEGENTA CROP PROTECTION, INC. (US) 2008-08-21 — — US disclosed
EP-1481970-B1 Novel herbicides SYNGENTA PARTICIPATIONS AG (CH) 2006-03-22 — — EP disclosed
US-20060030485-A1 Herbicide/safener combinations AVENTIS CROPSCIENCE GMBH 2006-02-09 — — US disclosed
US-6962894-B1 comprise a herbicide and a safener (counter-agent, antidote) and protect the useful plants, but not the weeds, against the phytotoxic action of the herbicide SYNGENTA CROP PROTECTION, INC. (US) 2005-11-08 — — US disclosed
US-20050187110-A1 mixtures with plant safening agents used for selectively controlling weeds and grasses in crops of useful plants MAETZKE THOMAS (CH) 2005-08-25 — — US disclosed
US-20050164883-A1 agronomically tolerable salts, isomers and enantiomers of those compounds, are suitable for use as herbicides MAETZKE THOMAS (CH) 2005-07-28 — — US disclosed
EP-1481970-A1 Novel herbicides Syngenta Participations AG (CH) 2004-12-01 — — EP disclosed
EP-1210333-B1 p-Tolyl-heterocycles as herbicides SYNGENTA PARTICIPATIONS AG (CH) 2004-11-17 — — EP disclosed
EP-1468000-A1 PHENYL SUBSTITUTED HETEROCYCLIC COMPOUNDS USEFUL AS HERBICIDES Syngenta Participations AG (CH) 2004-10-20 — — EP disclosed
WO-2003062244-A1 PHENYL SUBSTITUTED HETEROCYCLIC COMPOUNDS USEFUL AS HERBICIDES SYNGENTA PARTICIPATIONS AG (CH) 2003-07-31 — — WO disclosed
EP-1210333-A2 NOVEL HERBICIDES Syngenta Participations AG (CH) 2002-06-05 — — EP disclosed
EP-1209975-A1 HERBICIDAL COMPOSITION Syngenta Participations AG (CH) 2002-06-05 — — EP disclosed
EP-1130965-A1 COMBINATIONS OF HERBICIDES AND SAFENERS Aventis CropScience GmbH (DE) 2001-09-12 — — EP disclosed
WO-2001017353-A1 HERBICIDAL COMPOSITION SYNGENTA PARTICIPATIONS AG (CH) 2001-03-15 — — WO disclosed
WO-2001017972-A2 NOVEL HERBICIDES SYNGENTA PARTICIPATIONS AG (CH) 2001-03-15 — — WO disclosed
WO-2000030447-A1 COMBINATIONS OF HERBICIDES AND SAFENERS AVENTIS CROPSCIENCE GMBH (DE) 2000-06-02 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120322657-A1 HERBICIDE/SAFENER COMBINTIONS DDT, DERL1, SLC16A7 FLT1 2250/4885FLT4 2332/4885KDR 3617/4885
US-20060030485-A1 Herbicide/safener combinations DDT, DERL1, SLC16A7 FLT1 1862/4885FLT4 2312/4885KDR 3000/4885
US-20050164883-A1 agronomically tolerable salts, isomers and enantiomers of those compounds, are suitable for use as herbicides DDT, SULT2A1, GSTA1 FLT1 2672/4885FLT4 3556/4885KDR 2780/4885
US-20080200336-A1 HERBICIDAL COMPOSITION MTX2, DDT, AGPS FLT1 3754/4885FLT4 4080/4885KDR 3400/4885
US-20050187110-A1 mixtures with plant safening agents used for selectively controlling weeds and grasses in crops of useful plants PIN1, GMDS, DDT FLT1 3866/4885FLT4 4279/4885KDR 4212/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.