SCHEMBL450208

SCHEMBL450208

[c]1[c]c2ccccc2nn1

nearest known ligand 0.35

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GPR3 P46089 1/20 0.35
MAPT P10636 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8879 0.67 GPR3 (0.35) GPR3MAPT
SCHEMBL1395756 0.67 MAPT (0.33) MAPT
SCHEMBL80737 0.62 GPR3 (0.35) GPR3MAPT
SCHEMBL452301 0.62 MAPT (0.33) MAPT
SCHEMBL5767319 0.60 GPR3 (0.39) GPR3MAPT
SCHEMBL95080 0.60 GPR3 (0.38) GPR3MAPT
SCHEMBL1395705 0.60
SCHEMBL56536 0.58 MAPT (0.32) MAPT
SCHEMBL400612 0.58 MAPT (0.47) GPR3MAPT
SCHEMBL23981 0.58 MAPT (0.56) GPR3MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 302 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6946207-B2 Electroconductive device, organic electroluminescence device using the device and process for producing the electroconductive device CANON KABUSHIKI KAISHA (JP) 2005-09-20 US claimed
US-20020135292-A1 Electroconductive device, organic electroluminescence device using the device and process for producing the electroconductive device CANON KABUSHIKI KAISHA (JP) 2002-09-26 US claimed
US-5081245-A Selective antitumor agents TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1992-01-14 US claimed
US-12630510-B2 EP2 antagonist ONO PHARMACEUTICAL CO., LTD. (JP) 2026-05-19 US disclosed
EP-4727924-A1 INHIBITORS OF TREK (TWIK RELATED K+ CHANNELS) CHANNEL FUNCTION ONO Pharmaceutical Co., Ltd. (JP) 2026-04-22 EP disclosed
US-12497377-B2 Tricyclic spiro compound ONO PHARMACEUTICAL CO., LTD. (JP) 2025-12-16 US disclosed
EP-3992176-B1 EP2 ANTAGONIST ONO PHARMACEUTICAL CO (JP) 2025-08-27 EP disclosed
US-20250188023-A1 BENZENE DERIVATIVE ONO PHARMACEUTICAL CO., LTD. (JP) 2025-06-12 US disclosed
US-12258308-B2 Benzene derivative ONO PHARMACEUTICAL CO., LTD. (JP) 2025-03-25 US disclosed
US-20250042870-A1 DP ANTAGONIST ONO PHARMACEUTICAL CO., LTD. (JP) 2025-02-06 US disclosed
US-20250034187-A1 STING AGONISTIC COMPOUND ONO PHARMACEUTICAL CO., LTD. (JP) 2025-01-30 US disclosed
US-20020135292-A1 Electroconductive device, organic electroluminescence device using the device and process for producing the electroconductive device CANON KABUSHIKI KAISHA (JP) 2002-09-26 US disclosed
US-20010053377-A1 Process for increasing the persistence of at least one cosmetic effet and/or care effect of a cosmetic composition, cosmetic composition and use thereof L'OREAL (FR) 2001-12-20 US disclosed
US-20010051171-A1 Cosmetic use of at least one polyorganosiloxane as a gelling agent and cosmetic composition containing it L'OREAL (FR) 2001-12-13 US disclosed
US-6051722-A PRECURSOR FOR POLYIMIDE COPOLYMER; USABLE IN OPTICAL LONG-DISTANCE COMMUNICATION, SIGNAL PROCESSING, PHOTOELECTRIC HYBRID CIRCUITS AND OPTICAL COMPUTERS HITACHI CHEMICAL COMPANY, LTD. (JP) 2000-04-18 US disclosed
US-5834575-A POLYIMIDE OR POLYACRYLATE WITH PENDANT GROUP CONTAINING THIOPHENE RING, BENZENE RING AND VICINAL NITRILE GROUPS, SWITCHES FOR OPTICAL SIGNALS, COMMUNICATION TECHNOLOGY HITACHI CHEMICAL COMPANY, LTD. (JP) 1998-11-10 US disclosed
US-5081245-A Selective antitumor agents TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1992-01-14 US disclosed
US-4952490-A LOW FOG; HIGH SPEED DEVELOPMENT FUJI PHOTO FILM CO., LTD. (JP) 1990-08-28 US disclosed
US-4952491-A LOW FOG AND HIGH SPECTRAL SENSITIVITY; RAPID PROCESSING; CRYSTAL HABIT CONTROL FUJI PHOTO FILM CO., LTD. (JP) 1990-08-28 US disclosed
EP-0356765-A2 Carboxylic acid derivatives, their production and use Takeda Chemical Industries, Ltd. (JP) 1990-03-07 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250034187-A1 STING AGONISTIC COMPOUND STING1, IRF3, MAVS GPR3 320/4885MAPT 4099/4885
US-12258308-B2 Benzene derivative PMP22, TMBIM6, MYT1 GPR3 4558/4885MAPT 2169/4885
US-20250188023-A1 BENZENE DERIVATIVE PMP22, TMBIM6, MYT1 GPR3 4563/4885MAPT 2085/4885
US-20010053377-A1 Process for increasing the persistence of at least one cosmetic effet and/or care effect of a cosmetic composition, cosmetic composition and use thereof CUTA, LAGE3, MITF GPR3 1493/4885MAPT 602/4885
US-12630510-B2 EP2 antagonist PTGER2, PTGER1, PTGER4 GPR3 71/4885MAPT 4697/4885
US-12497377-B2 Tricyclic spiro compound PTGER4, PTGER1, PTGER3 GPR3 113/4885MAPT 4700/4885
US-20250042870-A1 DP ANTAGONIST OPRL1, CNR1, NPSR1 GPR3 37/4885MAPT 3282/4885
US-20010051171-A1 Cosmetic use of at least one polyorganosiloxane as a gelling agent and cosmetic composition containing it CUTA, LPO, PRDX1 GPR3 3868/4885MAPT 4785/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.