Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Ethylene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 known ✓ | P00918 | 3/20 | 0.35 |
| ▸ | CA4 known ✓ | P22748 | 1/20 | 0.35 |
| ▸ | CA1 known ✓ | P00915 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | PKLR | P30613 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | NT5E | P21589 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL143946 | 0.96 | ALDH1A1 (0.48) | ALDH1A1KDM4EHPGDCA2CA4 | |
| SCHEMBL28372305 | 0.92 | ALDH1A1 (0.43) | ALDH1A1KDM4EHPGDCA2CA4 | |
| Zinc Ion SCHEMBL28885473 | 0.92 | ALDH1A1 (0.43) | ALDH1A1KDM4EHPGDCA2CA4 | |
| Lithium Ion SCHEMBL756013 | 0.92 | ALDH1A1 (0.43) | ALDH1A1KDM4EHPGDCA2CA4 | |
| SCHEMBL5964463 | 0.92 | ALDH1A1 (0.43) | ALDH1A1KDM4EHPGDCA2CA4 | |
| SCHEMBL1041780 | 0.92 | ALDH1A1 (0.43) | ALDH1A1KDM4EHPGDCA2CA4 | |
| SCHEMBL1400955 | 0.92 | ALDH1A1 (0.43) | ALDH1A1KDM4EHPGDCA2CA4 | |
| Potassium Ion SCHEMBL3781302 | 0.92 | ALDH1A1 (0.43) | ALDH1A1KDM4EHPGDCA2CA4 | |
| SCHEMBL548212 | 0.89 | ALOX15 (0.49) | ALDH1A1KDM4EHPGDCA2CA4 | |
| SCHEMBL31552763 | 0.87 | KDM4E (0.41) | ALDH1A1KDM4EHPGDCA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463632-B1 | HIGH BULK COMPOSITE SHEETS AND METHOD FOR PREPARING | INVISTA TECH SARL (CH) | 2013-05-15 | — | — | EP | claimed |
| US-8252706-B2 | Stretchable multiple component nonwoven fabrics and methods for preparing | Invista North America S.àr.l. (US) | 2012-08-28 | — | — | US | claimed |
| EP-1430168-B1 | STRETCHABLE MULTIPLE COMPONENT SPUNBOND WEBS AND A PROCESS FOR MAKING | DU PONT (US) | 2007-06-20 | — | — | EP | claimed |
| US-7201816-B2 | High bulk composite sheets and method for preparing | INVISTA NORTH AMERICA S.A.R.L. (US) | 2007-04-10 | — | — | US | claimed |
| EP-1456017-B1 | STRETCHABLE COMPOSITE SHEETS AND PROCESSES FOR MAKING | INVISTA TECH SARL (US) | 2007-03-07 | — | — | EP | claimed |
| US-7005395-B2 | Stretchable composite sheets and processes for making | INVISTA NORTH AMERICA S.A.R.L. (US) | 2006-02-28 | — | — | US | claimed |
| US-6887423-B2 | Process for making a stretchable nonwoven web | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2005-05-03 | — | — | US | claimed |
| EP-1463632-A1 | HIGH BULK COMPOSITE SHEETS AND METHOD FOR PREPARING | INVISTA Technologies S.à.r.l. (US) | 2004-10-06 | — | — | EP | claimed |
| EP-1456017-A1 | STRETCHABLE COMPOSITE SHEETS AND PROCESSES FOR MAKING | Invista Technologies S.à.r.l. (US) | 2004-09-15 | — | — | EP | claimed |
| EP-1430168-A1 | STRETCHABLE MULTIPLE COMPONENT SPUNBOND WEBS AND A PROCESS FOR MAKING | E. I. du Pont de Nemours and Company (US) | 2004-06-23 | — | — | EP | claimed |
| US-20040116024-A1 | Stretchable composite sheets and processes for making | THE LYCRA COMPANY LLC | 2004-06-17 | — | — | US | claimed |
| US-20030134094-A1 | High bulk composite sheets and method for preparing | THE LYCRA COMPANY LLC | 2003-07-17 | — | — | US | claimed |
| WO-2003055675-A1 | HIGH BULK COMPOSITE SHEETS AND METHOD FOR PREPARING | INVISTA TECHNOLOGIES S.À.R.L. (US) | 2003-07-10 | — | — | WO | claimed |
| WO-2003055674-A1 | STRETCHABLE COMPOSITE SHEETS AND PROCESSES FOR MAKING | INVISTA TECHNOLOGIES S.À.R.L. (US) | 2003-07-10 | — | — | WO | claimed |
| WO-2003027364-A1 | STRETCHABLE MULTIPLE COMPONENT SPUNBOND WEBS AND A PROCESS FOR MAKING | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2003-04-03 | — | — | WO | claimed |
| US-20030064650-A1 | Stretchable multiple component spunbond webs and a process for making | DUPONT SAFETY & CONSTRUCTION, INC. | 2003-04-03 | — | — | US | claimed |
| EP-1463632-B1 | HIGH BULK COMPOSITE SHEETS AND METHOD FOR PREPARING | INVISTA TECH SARL (CH) | 2013-05-15 | — | — | EP | disclosed |
| US-8252706-B2 | Stretchable multiple component nonwoven fabrics and methods for preparing | Invista North America S.àr.l. (US) | 2012-08-28 | — | — | US | disclosed |
| US-4639347-A | Process of making crimped, annealed polyester filaments | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1987-01-27 | — | — | US | disclosed |
| EP-0125112-A2 | Improved process for annealing polyester filaments and new products thereof | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1984-11-14 | — | — | EP | disclosed |