SCHEMBL454277

SCHEMBL454277

C1=Cc2c([nH]c3ccccc23)CC1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 1/20 0.43
HTR2C P28335 1/20 0.43
KDM4E B2RXH2 4/20 0.42
CHRNA7 P36544 1/20 0.42
NR2E1 Q9Y466 2/20 0.42
HTR5A P47898 1/20 0.42
NISCH Q9Y2I1 1/20 0.42
ALDH1A1 P00352 2/20 0.41
GPR3 P46089 1/20 0.41
HSD17B10 Q99714 1/20 0.41
TAAR1 Q96RJ0 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.40
DRD2 P14416 2/20 0.39
DRD1 P21728 2/20 0.39
DRD4 P21917 2/20 0.39
DRD5 P21918 2/20 0.39
DRD3 P35462 2/20 0.39
MEN1 O00255 1/20 0.39
GMNN O75496 1/20 0.39
CYP1A2 P05177 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetic Acid SCHEMBL11557557 0.89 MAPT (0.44) KDM4ECHRNA7NR2E1HTR5ANISCH
SCHEMBL12810775 0.84 GABRP (0.46) HTR2AHTR2CKDM4ENR2E1HTR5A
SCHEMBL1825781 0.81 HTR2A (0.46) HTR2AHTR2CKDM4ECHRNA7NR2E1
SCHEMBL29048836 0.80 DRD2 (0.36) HTR2AHTR2CKDM4ENR2E1HTR5A
SCHEMBL18627138 0.80 AHR (0.42) HTR2AHTR2CKDM4ECHRNA7NR2E1
SCHEMBL21474736 0.80 KDM4E (0.35) KDM4EHSD17B10MEN1KMT2A
SCHEMBL21765729 0.79 SIRT2 (0.40)
SCHEMBL15583456 0.77 FEN1 (0.42) KDM4EMEN1KMT2A
SCHEMBL9883322 0.76 PGR (0.39) KDM4ECHRNA7ALDH1A1GPR3HSD17B10
SCHEMBL22474355 0.76 BAZ2B (0.40) HTR2AHTR2CCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 624 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113861128-A Polymerizable compound and optically anisotropic body 江苏创拓新材料有限公司 2021-12-31 CN claimed
CN-112939845-A Synthesis method of diversified [60] fullerene 1, 2-tetrahydrocarbazole derivative 河南师范大学 2021-06-11 CN claimed
EP-1852420-B1 Indole compounds for treating respiratory disorders ONO PHARMACEUTICAL CO (JP) 2012-10-17 EP claimed
US-8153625-B2 Nitrogen-containing heterocyclic compounds and medicinal use thereof ONO PHARMACEUTICAL CO., LTD. (JP) 2012-04-10 US claimed
US-20110280806-A1 DYE CONJUGATE IMAGING AGENTS GE HEALTHCARE AS (NO) 2011-11-17 US claimed
EP-2373349-A1 DYE CONJUGATE IMAGING AGENTS GE Healthcare AS (NO) 2011-10-12 EP claimed
WO-2010057944-A9 DYE CONJUGATE IMAGING AGENTS GE HEALTHCARE AS (NO) 2010-09-16 WO claimed
US-7759336-B2 Nitrogen-containing heterocyclic compounds and medicinal use thereof ONO PHARMACEUTICAL CO., LTD. (JP) 2010-07-20 US claimed
WO-2010057944-A1 DYE CONJUGATE IMAGING AGENTS GE HEALTHCARE AS (NO) 2010-05-27 WO claimed
US-12600730-B2 Substituted cyclopenta[c]pyrroles as ABHD6 antagonists ONO PHARMACEUTICAL CO., LTD. (JP) 2026-04-14 US disclosed
US-20260083735-A1 ABHD6 ANTAGONIST ONO PHARMACEUTICAL CO., LTD. (JP) 2026-03-26 US disclosed
US-12535732-B2 Coloring composition, film, optical filter, solid-state imaging element and image display device FUJIFILM CORPORATION (JP) 2026-01-27 US disclosed
US-12529969-B2 Coloring composition, film, optical filter, solid-state imaging element, image display device, and compound FUJIFILM CORPORATION (JP) 2026-01-20 US disclosed
US-12529956-B2 Resin composition, film, optical filter, solid-state imaging element, and image display device FUJIFILM CORPORATION (JP) 2026-01-20 US disclosed
US-5892056-A THE RIGIDIFIED CHROMOPHORES HAVE NARROWED ABSORPTION BANDS RELATIVE TO CORRESPONDING NON-RIGID CHROMOPHORES. DYES PREPARED FROM THE DYE PRECURSORS OF THE INVENTION TYPICALLY HAVE GOOD SOLUBILITY IN NON-POLAR SOLVENTS. IMATION CORP. (US) 1999-04-06 US disclosed
EP-0010029-B1 ELLIPTICINES SUBSTITUTED IN POSITION 1 BY A POLYAMINE CHAIN, THEIR SYNTHESIS AND MEDICINES CONTAINING THEM ANVAR Agence Nationale de Valorisation de la Recherche (FR) 1982-11-17 EP disclosed
US-4234487-A Process of making a carbazole acetic acid HOFFMANN-LA ROCHE INC. (US) 1980-11-18 US disclosed
EP-0010029-A2 Ellipticines substituted in position 1 by a polyamine chain, their synthesis and medicines containing them ANVAR Agence Nationale de Valorisation de la Recherche (FR) 1980-04-16 EP disclosed
US-4179443-A ANTIINFLAMMATORY AGENTS, ANTIRHEUMATIC AGENTS, CHEMICAL INTERMEDIATES HOFFMANN-LA ROCHE INC. (US) 1979-12-18 US disclosed
US-4146542-A ANTIINFLAMMATORY AGENTS HOFFMANN-LA ROCHE INC. (US) 1979-03-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110280806-A1 DYE CONJUGATE IMAGING AGENTS DSC1, SDCBP, DOCK5 HTR2A 4760/4885HTR2C 4541/4885KDM4E 3469/4885
US-12535732-B2 Coloring composition, film, optical filter, solid-state imaging element and image display device SF1, RER1, SFXN1 HTR2A 2912/4885HTR2C 2667/4885KDM4E 3252/4885
US-12529969-B2 Coloring composition, film, optical filter, solid-state imaging element, image display device, and compound RER1, SEM1, SF1 HTR2A 3362/4885HTR2C 2734/4885KDM4E 4165/4885
US-12600730-B2 Substituted cyclopenta[c]pyrroles as ABHD6 antagonists ABHD6, ABHD16A, HDHD5 HTR2A 2861/4885HTR2C 2994/4885KDM4E 1505/4885
US-12529956-B2 Resin composition, film, optical filter, solid-state imaging element, and image display device PTGER1, CD40, FPR1 HTR2A 2370/4885HTR2C 2060/4885KDM4E 1145/4885
US-20260083735-A1 ABHD6 ANTAGONIST ABHD6, ABHD16A, ABHD12 HTR2A 2423/4885HTR2C 2982/4885KDM4E 2124/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.