Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRF1 | P14222 | 2/20 | 0.33 |
| ▸ | PTPRC | P08575 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4378541 | 0.76 | MAOA (0.38) | PRF1PTPRCMAOAMAOBLMNA | |
| SCHEMBL5009684 | 0.73 | ALOX5 (0.43) | PRF1MAOAMAOBLMNAKDM4E | |
| SCHEMBL17628649 | 0.72 | ITGB2 (0.43) | PRF1MAOAMAOBLMNAKDM4E | |
| SCHEMBL3874923 | 0.72 | ITGB2 (0.43) | PRF1MAOAMAOBLMNAKDM4E | |
| SCHEMBL22419 | 0.72 | ITGB2 (0.43) | PRF1MAOAMAOBLMNAKDM4E | |
| SCHEMBL5520002 | 0.72 | PRF1 (0.38) | PRF1PTPRCMAOAMAOBLMNA | |
| SCHEMBL2232672 | 0.71 | KMT2A (0.36) | LMNAKDM4EALDH1A1HTT | |
| SCHEMBL36556 | 0.71 | GSTP1 (0.45) | KDM4EALDH1A1MAPT | |
| SCHEMBL7108757 | 0.71 | MAOA (0.46) | PRF1PTPRCMAOAMAOBLMNA | |
| SCHEMBL102784 | 0.71 | ITGB2 (0.38) | LMNAKDM4EALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7553511-B2 | Hydrophilic coatings for medical implements | LIFESCAN, INC. (US) | 2009-06-30 | — | — | US | claimed |
| US-20060078587-A1 | Hydrophilic coatings for medical implements | CILAG GMBH INTERNATIONAL (CH) | 2006-04-13 | — | — | US | claimed |
| US-7015262-B2 | Hydrophilic coatings for medical implements | LIFESCAN, INC. (US) | 2006-03-21 | — | — | US | claimed |
| US-20030207987-A1 | Hydrophilic coatings for medical implements | LIFESCAN IP HOLDINGS, LLC | 2003-11-06 | — | — | US | claimed |
| US-7553511-B2 | Hydrophilic coatings for medical implements | LIFESCAN, INC. (US) | 2009-06-30 | — | — | US | disclosed |
| EP-1358896-B1 | Hydrophilic coating for medical needles | LIFESCAN INC (US) | 2006-12-27 | — | — | EP | disclosed |
| US-20060078587-A1 | Hydrophilic coatings for medical implements | CILAG GMBH INTERNATIONAL (CH) | 2006-04-13 | — | — | US | disclosed |
| US-7015262-B2 | Hydrophilic coatings for medical implements | LIFESCAN, INC. (US) | 2006-03-21 | — | — | US | disclosed |
| US-20030207987-A1 | Hydrophilic coatings for medical implements | LIFESCAN IP HOLDINGS, LLC | 2003-11-06 | — | — | US | disclosed |
| EP-1358896-A1 | Hydrophilic coating for medical implements | Lifescan, Inc. (US) | 2003-11-05 | — | — | EP | disclosed |