Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | HTR6 | P50406 | 2/20 | 0.61 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.56 |
| ▸ | CNR2 | P34972 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NSD2 | O96028 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11850699 | 0.91 | LMNA (0.70) | ALDH1A1MAPTLMNAKDM4EGAA | |
| SCHEMBL879249 | 0.87 | CNR2 (0.47) | ALDH1A1MAPTLMNAKDM4EGAA | |
| SCHEMBL24589993 | 0.83 | HTR6 (0.56) | ALDH1A1MAPTLMNAKDM4EGAA | |
| SCHEMBL31060472 | 0.83 | HTR6 (0.56) | ALDH1A1MAPTLMNAKDM4EGAA | |
| SCHEMBL11872140 | 0.83 | GAA (0.70) | ALDH1A1MAPTLMNAKDM4EGAA | |
| SCHEMBL11117363 | 0.83 | LMNA (0.70) | ALDH1A1MAPTLMNAKDM4EGAA | |
| SCHEMBL13272458 | 0.83 | ALDH1A1 (0.70) | ALDH1A1MAPTLMNAKDM4EGAA | |
| SCHEMBL8046879 | 0.82 | GAA (0.58) | ALDH1A1MAPTLMNAKDM4EGAA | |
| SCHEMBL23974988 | 0.82 | CNR2 (0.42) | ALDH1A1MAPTLMNAKDM4EGAA | |
| SCHEMBL10179635 | 0.82 | HTR6 (0.54) | ALDH1A1MAPTLMNAKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101208299-A | Diarylsulfone sulfonamides and use therof | WYETH CORP (US) | 2008-06-25 | — | — | CN | claimed |
| EP-1879859-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-23 | — | — | EP | claimed |
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | WYETH (US) | 2006-12-07 | — | — | US | claimed |
| WO-2006124875-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | WYETH (US) | 2006-11-23 | — | — | WO | claimed |
| US-20230174506-A1 | (DI)AMINATION OF ACTIVATED ALLENE COMPOUNDS, DERIVATIVES THEREOF, AND METHODS FOR SYNTHESIS OF THE SAME | PURDUE RESEARCH FOUNDATION | 2023-06-08 | — | — | US | disclosed |
| WO-2021099447-A1 | POLYMERS, COMPOSITIONS AND METHOD FOR MANUFACTURING AN ARTICLE BY 3D PRINTING | SOLVAY SPECIALTY POLYMERS USA, LLC (US) | 2021-05-27 | — | — | WO | disclosed |
| US-10472564-B2 | Delayed fluorescence compound and organic electroluminescent device using the same | LUMINESCENCE TECHNOLOGY CORP. (TW) | 2019-11-12 | — | — | US | disclosed |
| US-20190093009-A1 | DELAYED FLUORESCENCE COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE USING THE SAME | LUMINESCENCE TECHNOLOGY CORPORATION (TW) | 2019-03-28 | — | — | US | disclosed |
| US-20170244034-A1 | AROMATIC COMPOUND AND ORGANIC LIGHT-EMITTING DIODE INCLUDING THE SAME | NATIONAL TSING HUA UNIVERSITY (TW) | 2017-08-24 | — | — | US | disclosed |
| US-20170244034-A1 | AROMATIC COMPOUND AND ORGANIC LIGHT-EMITTING DIODE INCLUDING THE SAME | NATIONAL TSING HUA UNIVERSITY (TW) | 2017-08-24 | — | — | US | disclosed |
| US-9187459-B2 | Quinazoline-7-ether compounds and methods of use | NEWGEN THERAPEUTICS, INC. (US) | 2015-11-17 | — | — | US | disclosed |
| US-20140221406-A1 | QUINAZOLINE-7-ETHER COMPOUNDS AND METHODS OF USE | NEWGEN THERAPEUTICS, INC. (US) | 2014-08-07 | — | — | US | disclosed |
| US-7696210-B2 | Gonadotropin releasing hormone receptor antagonists | WYETH (US) | 2010-04-13 | — | — | US | disclosed |
| US-7696210-B2 | Gonadotropin releasing hormone receptor antagonists | WYETH (US) | 2010-04-13 | — | — | US | disclosed |
| US-20090170845-A1 | USE OF IMIDAZO[2,1-b]-1,3,4-THIADIAZOLE-2-SULFONAMIDE COMPOUNDS TO TREAT NEUROPATHIC PAIN | AEGERA THERAPEUTICS INC. (CA) | 2009-07-02 | — | — | US | disclosed |
| US-20090170845-A1 | USE OF IMIDAZO[2,1-b]-1,3,4-THIADIAZOLE-2-SULFONAMIDE COMPOUNDS TO TREAT NEUROPATHIC PAIN | AEGERA THERAPEUTICS INC. (CA) | 2009-07-02 | — | — | US | disclosed |
| CN-101208299-A | Diarylsulfone sulfonamides and use therof | WYETH CORP (US) | 2008-06-25 | — | — | CN | disclosed |
| EP-1879859-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | Wyeth a Corporation of the State of Delaware (US) | 2008-01-23 | — | — | EP | disclosed |
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | WYETH (US) | 2006-12-07 | — | — | US | disclosed |
| WO-2006124875-A2 | DIARYLSULFONE SULFONAMIDES AND USE THEROF | WYETH (US) | 2006-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090170845-A1 | USE OF IMIDAZO[2,1-b]-1,3,4-THIADIAZOLE-2-SULFONAMIDE COMPOUNDS TO TREAT NEUROPATHIC PAIN | SCN1B, SCN3A, SCN1A | ALDH1A1 658/4885MAPT 2535/4885LMNA 4033/4885 |
| US-20230174506-A1 | (DI)AMINATION OF ACTIVATED ALLENE COMPOUNDS, DERIVATIVES THEREOF, AND METHODS FOR SYNTHESIS OF THE SAME | NAAA, PAM, AANAT | ALDH1A1 583/4885MAPT 3692/4885LMNA 1994/4885 |
| US-20170244034-A1 | AROMATIC COMPOUND AND ORGANIC LIGHT-EMITTING DIODE INCLUDING THE SAME | ARNT, AHR, CYP1A1 | ALDH1A1 11/4885MAPT 748/4885LMNA 3515/4885 |
| US-10472564-B2 | Delayed fluorescence compound and organic electroluminescent device using the same | SLCO4C1, LEF1, SLCO2A1 | ALDH1A1 2768/4885MAPT 926/4885LMNA 1633/4885 |
| US-20140221406-A1 | QUINAZOLINE-7-ETHER COMPOUNDS AND METHODS OF USE | ABL1, ERBB4, ERBB2 | ALDH1A1 3808/4885MAPT 3552/4885LMNA 2534/4885 |
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | SFRP1, SOS1, FZD7 | ALDH1A1 1865/4885MAPT 4680/4885LMNA 4608/4885 |
| US-20190093009-A1 | DELAYED FLUORESCENCE COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE USING THE SAME | SLCO4C1, LEF1, SLCO2A1 | ALDH1A1 2768/4885MAPT 926/4885LMNA 1633/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.