Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20336329 | 0.81 | KIF11 (0.61) | KIF11GABRA1GABRB3GABRG2GABRB2 | |
| SCHEMBL13619662 | 0.77 | KIF11 (0.45) | KIF11GABRA1GABRB3GABRG2GABRB2 | |
| SCHEMBL6105719 | 0.77 | KIF11 (0.49) | KIF11GABRA1GABRB3GABRG2GABRB2 | |
| SCHEMBL20261725 | 0.77 | KIF11 (0.45) | KIF11GABRA1GABRB3GABRG2GABRB2 | |
| SCHEMBL14655026 | 0.77 | KIF11 (0.49) | KIF11GABRA1GABRB3GABRG2GABRB2 | |
| SCHEMBL23860299 | 0.77 | KIF11 (0.45) | KIF11GABRA1GABRB3GABRG2GABRB2 | |
| SCHEMBL993831 | 0.77 | KIF11 (0.41) | KIF11GABRA1GABRB3GABRG2GABRB2 | |
| SCHEMBL80368 | 0.76 | KIF11 (0.43) | KIF11GABRA1GABRB3GABRG2GABRB2 | |
| SCHEMBL586923 | 0.75 | ADRA2A (0.43) | KIF11GABRA1GABRB3GABRG2GABRB2 | |
| SCHEMBL15370170 | 0.74 | KIF11 (0.42) | KIF11GABRA1GABRB3GABRG2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233041-B1 | COSMETIC PROCESS FOR ATTENUATING WRINKLES | OREAL (FR) | 2019-01-30 | — | — | EP | disclosed |
| US-20170216252-A1 | ANTI-BACTERIAL PYRUVATE KINASE MODULATOR COMPOUNDS, COMPOSITIONS, USES AND METHODS | SIMON FRASER UNIVERSITY (CA) | 2017-08-03 | — | — | US | disclosed |
| WO-2016004513-A1 | ANTI-BACTERIAL PYRUVATE KINASE MODULATOR COMPOUNDS, COMPOSITIONS, USES AND METHODS | SIMON FRASER UNIVERSITY (CA) | 2016-01-14 | — | — | WO | disclosed |
| EP-1694281-A4 | BIPHENYL COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2008-12-24 | — | — | EP | disclosed |
| US-20070265345-A1 | Novel Biphenyl Compounds And Their Use | SMITHKLINE BEECHAM CORPORATION (US) | 2007-11-15 | — | — | US | disclosed |
| US-20070259951-A1 | Compounds, Compositions and Methods | SMITHKLINE BEECHAM CORPORATION (US) | 2007-11-08 | — | — | US | disclosed |
| EP-1778214-A2 | NOVEL BIPHENYL COMPOUNDS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2007-05-02 | — | — | EP | disclosed |
| EP-1694281-A2 | BIPHENYL COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-08-30 | — | — | EP | disclosed |
| WO-2006020358-A2 | NOVEL BIPHENYL COMPOUNDS AND THEIR USE | SMITHKLINE BEECHAM CORPORATION (US) | 2006-02-23 | — | — | WO | disclosed |
| WO-2005060692-A2 | BIPHENYL COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070265345-A1 | Novel Biphenyl Compounds And Their Use | KIF5B, KIF5C, KIF5A | KIF11 8/4885GABRA1 2363/4885GABRB3 1738/4885 |
| US-20070259951-A1 | Compounds, Compositions and Methods | ALPP, PCNA, MKI67 | KIF11 824/4885GABRA1 4345/4885GABRB3 3468/4885 |
| US-20170216252-A1 | ANTI-BACTERIAL PYRUVATE KINASE MODULATOR COMPOUNDS, COMPOSITIONS, USES AND METHODS | PDK1, PDK3, PDK2 | KIF11 3428/4885GABRA1 3363/4885GABRB3 2815/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.