Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.43 |
| ▸ | CA12 known ✓ | O43570 | 3/20 | 0.43 |
| ▸ | CA2 known ✓ | P00918 | 3/20 | 0.43 |
| ▸ | PTGS1 known ✓ | P23219 | 3/20 | 0.42 |
| ▸ | PTGS2 known ✓ | P35354 | 3/20 | 0.42 |
| ▸ | SLC7A11 | Q9UPY5 | 3/20 | 0.52 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 2/20 | 0.46 |
| ▸ | GLB1 | P16278 | 1/20 | 0.46 |
| ▸ | CHAT | P28329 | 1/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.46 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.46 |
| ▸ | CTRC | Q99895 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LTA | P01374 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL339834 | 1.00 | SLC7A11 (0.52) | SLC7A11PLCG1APPGLB1CHAT | |
| SCHEMBL22974903 | 0.89 | SENP2 (0.53) | SLC7A11PLCG1APPGLB1CHAT | |
| SCHEMBL29837421 | 0.89 | SENP2 (0.50) | SLC7A11PLCG1APPGLB1CHAT | |
| SCHEMBL11200690 | 0.82 | CA12 (0.51) | SLC7A11PLCG1APPGLB1CHAT | |
| SCHEMBL11202854 | 0.82 | PTGS1 (0.53) | SLC7A11PLCG1APPGLB1CHAT | |
| SCHEMBL11202850 | 0.82 | PTGS1 (0.53) | SLC7A11PLCG1APPGLB1CHAT | |
| SCHEMBL11200679 | 0.82 | CA12 (0.51) | SLC7A11PLCG1APPGLB1CHAT | |
| SCHEMBL8772805 | 0.80 | LMNA (0.47) | SLC7A11CA12CA2CA9MAPT | |
| SCHEMBL9618266 | 0.78 | CA12 (0.68) | SLC7A11PLCG1THRBCA12CA2 | |
| SCHEMBL2394481 | 0.78 | CA12 (0.68) | SLC7A11PLCG1THRBCA12CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8262201-B2 | Micro writing and reading | HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. (US) | 2012-09-11 | — | — | US | disclosed |
| US-20080252690-A1 | Micro Writing And Reading | HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. | 2008-10-16 | — | — | US | disclosed |