Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 known ✓ | O43570 | 7/20 | 0.51 |
| ▸ | CA2 known ✓ | P00918 | 7/20 | 0.51 |
| ▸ | CA1 known ✓ | P00915 | 1/20 | 0.51 |
| ▸ | CA4 known ✓ | P22748 | 1/20 | 0.51 |
| ▸ | PTGS1 known ✓ | P23219 | 5/20 | 0.45 |
| ▸ | PTGS2 known ✓ | P35354 | 5/20 | 0.45 |
| ▸ | THRB known ✓ | P10828 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 7/20 | 0.51 |
| ▸ | CA7 | P43166 | 2/20 | 0.51 |
| ▸ | CA6 | P23280 | 1/20 | 0.51 |
| ▸ | CA5A | P35218 | 1/20 | 0.51 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.51 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.51 |
| ▸ | SLC7A11 | Q9UPY5 | 2/20 | 0.51 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.49 |
| ▸ | PHLPP2 | Q6ZVD8 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11200679 | 1.00 | CA12 (0.51) | CA12CA2CA9CA7CA1 | |
| SCHEMBL11200935 | 0.85 | CA2 (0.47) | CA12CA2CA9CA7CA1 | |
| SCHEMBL11200933 | 0.85 | CA2 (0.47) | CA12CA2CA9CA7CA1 | |
| SCHEMBL11200703 | 0.83 | POLB (0.53) | CA12CA2CA9CA7CA1 | |
| SCHEMBL4881910 | 0.82 | SLC7A11 (0.52) | CA12CA2CA9CA7SLC7A11 | |
| SCHEMBL339834 | 0.82 | SLC7A11 (0.52) | CA12CA2CA9CA7SLC7A11 | |
| SCHEMBL11202854 | 0.81 | PTGS1 (0.53) | CA12CA2CA9CA7CA1 | |
| SCHEMBL11202850 | 0.81 | PTGS1 (0.53) | CA12CA2CA9CA7CA1 | |
| SCHEMBL29837421 | 0.78 | SENP2 (0.50) | SLC7A11PLCG1PTGS1PTGS2THRB | |
| SCHEMBL2394481 | 0.77 | CA12 (0.68) | CA12CA2CA9CA7CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4419290-A | COLORFASTNESS | BASF AKTIENGESELLSCHAFT (DE) | 1983-12-06 | — | — | US | disclosed |