Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 4/20 | 0.37 |
| ▸ | CA1 | P00915 | 4/20 | 0.37 |
| ▸ | CA2 | P00918 | 4/20 | 0.37 |
| ▸ | CA4 | P22748 | 4/20 | 0.37 |
| ▸ | CA9 | Q16790 | 4/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL400376 | 0.94 | ALDH1A1 (0.40) | ALDH1A1TP53CA12CA1CA2 | |
| SCHEMBL6029546 | 0.92 | ALDH1A1 (0.34) | ALDH1A1TP53CA12CA1CA2 | |
| SCHEMBL401034 | 0.92 | ALDH1A1 (0.43) | ALDH1A1TP53CA12CA1CA2 | |
| SCHEMBL22958440 | 0.82 | DGKA (0.41) | ALDH1A1CA12CA1CA2CA4 | |
| SCHEMBL14696961 | 0.82 | ALDH1A1 (0.42) | ALDH1A1TP53TSHR | |
| SCHEMBL396155 | 0.81 | CA12 (0.41) | ALDH1A1CA12CA1CA2CA4 | |
| SCHEMBL457635 | 0.80 | LMNA (0.44) | ALDH1A1CA12CA1CA2CA4 | |
| SCHEMBL2014045 | 0.80 | CA12 (0.41) | ALDH1A1CA12CA1CA2CA4 | |
| Silver SCHEMBL2239077 | 0.78 | CA1 (0.38) | ALDH1A1CA12CA1CA2CA4 | |
| Methane SCHEMBL2013629 | 0.78 | LMNA (0.43) | ALDH1A1CA12CA1CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10450260-B2 | NO- and H2S-releasing compounds | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (US) | 2019-10-22 | — | — | US | disclosed |
| US-10450260-B2 | NO- and H2S-releasing compounds | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (US) | 2019-10-22 | — | — | US | disclosed |
| US-20170260124-A1 | NO- AND H2S- RELEASING COMPOUNDS | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK | 2017-09-14 | — | — | US | disclosed |
| US-20170260124-A1 | NO- AND H2S- RELEASING COMPOUNDS | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK | 2017-09-14 | — | — | US | disclosed |
| US-9688607-B2 | No- and H2S-releasing compounds | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (US) | 2017-06-27 | — | — | US | disclosed |
| US-9688607-B2 | No- and H2S-releasing compounds | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (US) | 2017-06-27 | — | — | US | disclosed |
| EP-2744487-B1 | NO- AND H2S- RELEASING COMPOUNDS | UNIV CITY NEW YORK RES FOUND (US) | 2016-10-05 | — | — | EP | disclosed |
| US-20140221316-A1 | NO- AND H2S- RELEASING COMPOUNDS | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (US) | 2014-08-07 | — | — | US | disclosed |
| US-20140221316-A1 | NO- AND H2S- RELEASING COMPOUNDS | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (US) | 2014-08-07 | — | — | US | disclosed |
| EP-2744487-A2 | NO- AND H2S- RELEASING COMPOUNDS | Research Foundation Of The City University Of New York (US) | 2014-06-25 | — | — | EP | disclosed |
| EP-1727787-A2 | NEW PROCESS FOR THE PREPARATION OF NITROOXYDERIVATIVES OF PARACETAMOL | NicOx S.A. (FR) | 2006-12-06 | — | — | EP | disclosed |
| US-20060167003-A1 | Probucol derivatives | NICOX S.A. (FR) | 2006-07-27 | — | — | US | disclosed |
| WO-2005054175-A2 | NEW PROCESS FOR THE PREPARATION OF NITROOXYDERIVATIVES OF PARACETAMOL | NICOX S.A. (FR) | 2005-06-16 | — | — | WO | disclosed |
| EP-1521740-A2 | PROBUCOL DERIVATIVES | Nicox S.A. (FR) | 2005-04-13 | — | — | EP | disclosed |
| US-6673819-B2 | NITRIC OXIDE RELEASING COMPOUND | ASTRAZENECA AB (SE) | 2004-01-06 | — | — | US | disclosed |
| WO-2003080568-A2 | PROBUCOL DERIVATIVES | NICOX S.A. (FR) | 2003-10-02 | — | — | WO | disclosed |
| US-20020111370-A1 | Compounds useful as antibacterial agents | ASTRAZENECA AB (SE) | 2002-08-15 | — | — | US | disclosed |
| EP-0192829-B1 | AMINO PROPANOL DERIVATIVES, PROCESS FOR THEIR PREPARATION, MEDICINES CONTAINING THESE COMPOUNDS AND INTERMEDIATES | Roche Diagnostics GmbH (DE) | 1990-09-26 | — | — | EP | disclosed |
| US-4801596-A | Nitroxy amino propanols for treating heart and circulatory diseases | BOEHRINGER MANNHEIM GMBH (DE) | 1989-01-31 | — | — | US | disclosed |
| EP-0192829-A1 | Amino propanol derivatives, process for their preparation, medicines containing these compounds and intermediates | Roche Diagnostics GmbH (DE) | 1986-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221316-A1 | NO- AND H2S- RELEASING COMPOUNDS | PTGS1, NOS2, NOS1 | ALDH1A1 363/4885TP53 1179/4885CA12 3042/4885 |
| US-20170260124-A1 | NO- AND H2S- RELEASING COMPOUNDS | NOS2, NOS3, NOS1 | ALDH1A1 961/4885TP53 302/4885CA12 2261/4885 |
| US-20060167003-A1 | Probucol derivatives | PNLIP, APOB, LIPC | ALDH1A1 511/4885TP53 2075/4885CA12 4215/4885 |
| US-10450260-B2 | NO- and H2S-releasing compounds | NOS2, NOS3, NOS1 | ALDH1A1 961/4885TP53 302/4885CA12 2261/4885 |
| US-20020111370-A1 | Compounds useful as antibacterial agents | NOS1, NOS2, PTGS1 | ALDH1A1 1397/4885TP53 4652/4885CA12 3795/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.