Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | ALDH1A2 | O94788 | 2/20 | 0.41 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10012522 | 0.88 | ADORA1 (0.46) | RAB9AMAPTNPC1SMN1; SMN2LMNA | |
| SCHEMBL31364389 | 0.88 | PTGS2 (0.53) | RAB9AMAPTNPC1SMN1; SMN2LMNA | |
| SCHEMBL4549458 | 0.84 | ALDH1A3 (0.51) | RAB9ANPC1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL16577135 | 0.84 | ALDH1A1 (0.39) | RAB9AMAPTNPC1SMN1; SMN2LMNA | |
| SCHEMBL82549 | 0.78 | PTGS1 (0.62) | RAB9AMAPTNPC1SMN1; SMN2LMNA | |
| SCHEMBL5345839 | 0.77 | MAPT (0.61) | RAB9AMAPTNPC1SMN1; SMN2LMNA | |
| SCHEMBL14007394 | 0.77 | SMN1; SMN2 (0.48) | RAB9AMAPTNPC1SMN1; SMN2LMNA | |
| SCHEMBL3101049 | 0.76 | RAB9A (0.46) | RAB9AMAPTNPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL11367856 | 0.74 | ALDH1A1 (0.63) | RAB9AMAPTNPC1SMN1; SMN2ALDH1A1 | |
| Bromide SCHEMBL10012418 | 0.73 | SMN1; SMN2 (0.46) | RAB9AMAPTNPC1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240002350-A1 | PROTEIN AND LIPID THERAPEUTIC TARGETS | UNIV PITTSBURGH COMMONWEALTH SYS HIGHER EDUCATION (US) | 2024-01-04 | — | — | US | disclosed |
| WO-2022108980-A1 | PROTEIN AND LIPID THERAPEUTIC TARGETS | UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2022-05-27 | — | — | WO | disclosed |
| WO-2008085008-A1 | T-CELL INHIBITING COMPOUNDS AND THEIR USE FOR THE TREATMENT OF T-CELL-MEDIATED DISEASES | MOGAM BIOTECHNOLOGY RESEARCH INSTITUTE (KR) | 2008-07-17 | — | — | WO | disclosed |
| EP-1888575-A2 | COMPOUNDS FOR MODULATING TRPV3 FUNCTION | Hydra Biosciences, Inc. (US) | 2008-02-20 | — | — | EP | disclosed |
| US-20070082918-A1 | NEUROLOGICALLY ACTIVE COMPOUNDS AND COMPOUNDS WITH MULTIPLE ACTIVITIES | NAFTCHI N E | 2007-04-12 | — | — | US | disclosed |
| WO-2006122156-A2 | COMPOUNDS FOR MODULATING TRPV3 FUNCTION | HYDRA BIOSCIENCES, INC. (US) | 2006-11-16 | — | — | WO | disclosed |
| US-7109329-B2 | Neurologically active compounds and compounds with multiple activities | NAFTCHI N ERIC | 2006-09-19 | — | — | US | disclosed |
| US-20040092536-A1 | Neurologically active compounds and compounds with multiple activities | NAFTCHI N ERIC (US) | 2004-05-13 | — | — | US | disclosed |
| US-6413962-B1 | ANESTHESIA AND TEMPERATURES REDUCTION; ALPHA-ADRENOCEPTOR AGONIST; RESTORATIVE TO CENTRAL NERVOUS SYSTEM, ESPECIALLY MOTOR AND SENSORY FUNCTIONAL LOSSES FROM TRAMATIC SPINAL CORD INJURIES; ANTISPASTICS; NONSEDATIVE; SIDE EFFECT REDUCTION | NAFTCHI N ERIC (US) | 2002-07-02 | — | — | US | disclosed |
| US-5958933-A | HAVING A GUANIDINO GROUP ALIPHATICALLY LINKED TO A XANTHINE GROUP, ADRENERGIC STIMULANTS | NAFTCHI N ERIC (US) | 1999-09-28 | — | — | US | disclosed |
| EP-0413751-A4 | NEUROLOGICALLY ACTIVE COMPOUNDS | — | 1992-07-22 | — | — | EP | disclosed |
| EP-0413751-A1 | NEUROLOGICALLY ACTIVE COMPOUNDS | NAFTCHI, N., Eric (US) | 1991-02-27 | — | — | EP | disclosed |
| WO-1989010744-A1 | NEUROLOGICALLY ACTIVE COMPOUNDS | NAFTCHI N ERIC (US) | 1989-11-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040092536-A1 | Neurologically active compounds and compounds with multiple activities | ACHE, GRIN2A, GRIK2 | RAB9A 135/4885MAPT 92/4885NPC1 942/4885 |
| US-20070082918-A1 | NEUROLOGICALLY ACTIVE COMPOUNDS AND COMPOUNDS WITH MULTIPLE ACTIVITIES | ADRB2, ADRB1, CHRNA7 | RAB9A 1141/4885MAPT 478/4885NPC1 372/4885 |
| US-20240002350-A1 | PROTEIN AND LIPID THERAPEUTIC TARGETS | PEBP1, ALOX15, ALOX15B | RAB9A 2624/4885MAPT 3258/4885NPC1 1408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.