SCHEMBL5144151

SCHEMBL5144151

COC(=O)COc1ccc(C[C@@H](C)NC[C@H](O)c2cccc(Cl)c2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ADRB3 P13945 14/20 1.00
ADRB2 P07550 11/20 1.00
ADRB1 P08588 8/20 1.00
GLA P06280 1/20 1.00
CYP2D6 P10635 2/20 0.83
ADRA1D P25100 1/20 0.83
ADRA1A P35348 1/20 0.83
ADRA1B P35368 1/20 0.83
CYP1A2 P05177 1/20 0.83
CYP2C9 P11712 1/20 0.83
CYP2C19 P33261 1/20 0.83
CYP3A4 P08684 1/20 0.80
HIF1A Q16665 1/20 0.80
SLC2A1 P11166 4/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5144149 1.00 ADRB3 (1.00) ADRB3ADRB2ADRB1GLACYP2D6
SCHEMBL9006835 1.00 ADRB3 (1.00) ADRB3ADRB2ADRB1GLACYP2D6
SCHEMBL5144153 1.00 ADRB3 (1.00) ADRB3ADRB2ADRB1GLACYP2D6
SCHEMBL4611391 1.00 ADRB3 (1.00) ADRB3ADRB2ADRB1GLACYP2D6
Bromide SCHEMBL29460100 0.99 ADRB3 (0.98) ADRB3ADRB2ADRB1GLACYP2D6
Bromide SCHEMBL9317314 0.99 ADRB3 (0.98) ADRB3ADRB2ADRB1GLACYP2D6
Bromide SCHEMBL9799484 0.99 ADRB3 (0.98) ADRB3ADRB2ADRB1GLACYP2D6
Trifluoroacetic Acid SCHEMBL9318455 0.94 ADRB3 (0.89) ADRB3ADRB2ADRB1GLACYP2D6
SCHEMBL9812022 0.91 ADRB3 (0.84) ADRB3ADRB2ADRB1GLACYP2D6
SCHEMBL9436811 0.91 ADRB3 (0.84) ADRB3ADRB2ADRB1GLACYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240301022-A1 GLYCOPROTEINS HAVING LIPID MOBILIZING PROPERTIES AND THERAPEUTIC USES THEREOF UNIV ASTON (GB) 2024-09-12 US claimed
WO-2022198259-A1 TREATMENT METHODS FOR PULMONARY ARTERIAL HYPERTENSION THE HEART RESEARCH INSTITUTE LTD (AU) 2022-09-29 WO claimed
JP-6293664-A None JP disclosed
US-20260077012-A1 COMPOSITIONS AND METHODS FOR DIAGNOSIS AND TREATMENT OF NEURODEGENERATIVE DISEASES EPITRACKER INC (US) 2026-03-19 US disclosed
US-12427179-B2 Compositions and methods for diagnosis and treatment of neurodegenerative diseases Epitracker, Inc. (US) 2025-09-30 US disclosed
US-20250262170-A1 COMBINATIONS OF BETA 2-ADRENERGIC RECEPTOR AGONISTS AND BETA 3-ADRENERGIC RECEPTOR AGONISTS, AND MEDICAL USES THEREOF ATROGI AB (SE) 2025-08-21 US disclosed
EP-4590287-A1 COMPOSITIONS AND METHODS FOR IMPROVING GUT PERMEABILITY Brightseed, Inc. (US) 2025-07-30 EP disclosed
US-20250205182-A1 COMPOSITIONS AND METHODS FOR IMPROVING GUT PERMEABILITY BRIGHTSEED, INC. 2025-06-26 US disclosed
US-20250134955-A1 TARGETED OESOPHAGEAL ADMINISTRATION OF ZN-ALPHA2-GLYCOPROTEINS (ZAG), METHODS AND FORMULATIONS THEREOF ASTON UNIVERSITY (GB) 2025-05-01 US disclosed
EP-4525833-A2 VETERINARY PHARMACEUTICAL FORMULATIONS Increvet, Inc. (US) 2025-03-26 EP disclosed
EP-4511014-A1 COMBINATIONS OF BETA 2-ADRENERGIC RECEPTOR AGONISTS AND BETA 3-ADRENERGIC RECEPTOR AGONISTS, AND MEDICAL USES THEREOF Atrogi AB (SE) 2025-02-26 EP disclosed
US-20220151957-A1 BIGUANIDE COMPOSITIONS AND METHODS OF TREATING METABOLIC DISORDERS ANJI PHARMACEUTICALS INC. 2022-05-19 US disclosed
WO-2022098572-A1 COMPOSITIONS AND METHODS FOR DIAGNOSIS AND TREATMENT OF CONDITIONS RELATED TO THE QUALITY OF AGING AND LONGEVITY Epitracker, Inc. (US) 2022-05-12 WO disclosed
EP-3971178-A1 AMINOQUINOLINE DERIVATIVES AND USES THEREOF The McLean Hospital Corporation (US) 2022-03-23 EP disclosed
US-20220054499-A1 SMALL MOLECULES FOR MOUSE SATELLITE CELL PROLIFERATION PRESIDENT AND FELLOWS OF HARVARD COLLEGE 2022-02-24 US disclosed
US-7217706-B2 Propanolamine derivatives ASTELLAS PHARMA INC. (JP) 2007-05-15 US disclosed
EP-1382333-A2 Use of beta 3 adrenergic receptor agonists in the treatment of dysuria FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-01-21 EP disclosed
US-6495546-B1 SUCH AS 1-(N-BENZYL-N-(3-METHOXY-6,7,8,9-TETRAHYDRO-5H-BENZO-CYCLOHEPTEN-6-YL)AMINO)-3-PHENOXY-2-PROPANOL; ADRENERGIC RECEPTOR AGONISTS; ANTIULCEROUS, LIPOLYTIC, ANTIURINARY INCONTINENCE AND ANTIPOLLAKIURIA ACTIVITIES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2002-12-17 US disclosed
US-20020120148-A1 Propanolamine derivatives FUJISAWA PHARMACEUTICAL CO. LTD. (JP) 2002-08-29 US disclosed
JP-H06293664-A NEW PHARMACEUTICAL USE OF BETA3-ADRENERGIC AGENT FUJISAWA PHARMACEUT CO LTD 1994-10-21 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250262170-A1 COMBINATIONS OF BETA 2-ADRENERGIC RECEPTOR AGONISTS AND BETA 3-ADRENERGIC RECEPTOR AGONISTS, AND MEDICAL USES THEREOF ADRB2, ADRB3, ADRB1 ADRB3 2/4885ADRB2 1/4885ADRB1 3/4885
US-20260077012-A1 COMPOSITIONS AND METHODS FOR DIAGNOSIS AND TREATMENT OF NEURODEGENERATIVE DISEASES CD4, COL2A1, MMP1 ADRB3 1713/4885ADRB2 2486/4885ADRB1 1355/4885
US-20220054499-A1 SMALL MOLECULES FOR MOUSE SATELLITE CELL PROLIFERATION MKI67, MYLK2, MYH2 ADRB3 3611/4885ADRB2 3615/4885ADRB1 3241/4885
US-20250205182-A1 COMPOSITIONS AND METHODS FOR IMPROVING GUT PERMEABILITY FABP2, VIP, SI ADRB3 2442/4885ADRB2 2344/4885ADRB1 2098/4885
US-20220151957-A1 BIGUANIDE COMPOSITIONS AND METHODS OF TREATING METABOLIC DISORDERS SLC5A2, SLC5A1, GPR119 ADRB3 1759/4885ADRB2 3376/4885ADRB1 2915/4885
US-20020120148-A1 Propanolamine derivatives AMY2A, PNMT, PNLIP ADRB3 12/4885ADRB2 7/4885ADRB1 6/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.