Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Dihydrofolic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS known ✓ | P04818 | 3/20 | 0.51 |
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.45 |
| ▸ | DHFR known ✓ | P00374 | 3/20 | 0.44 |
| ▸ | GART known ✓ | P22102 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.46 |
| ▸ | FPGS | Q05932 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MTHFD1 | P11586 | 2/20 | 0.44 |
| ▸ | ATIC | P31939 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dihydrofolic Acid SCHEMBL17080290 | 0.98 | LMNA (0.57) | LMNATYMSSOSTFPGSKDM4E | |
| Dihydrofolic Acid SCHEMBL17080287 | 0.98 | LMNA (0.57) | LMNATYMSSOSTFPGSKDM4E | |
| Dihydrofolic Acid SCHEMBL10461597 | 0.93 | SOST (0.53) | LMNATYMSSOSTFPGSKDM4E | |
| Dihydrofolic Acid SCHEMBL31299576 | 0.93 | SOST (0.53) | LMNATYMSSOSTFPGSKDM4E | |
| Dihydrofolic Acid SCHEMBL17080288 | 0.93 | SOST (0.53) | LMNATYMSSOSTFPGSKDM4E | |
| Dihydrofolic Acid SCHEMBL9637702 | 0.92 | SOST (0.52) | LMNATYMSSOSTFPGSKDM4E | |
| Dihydrofolic Acid SCHEMBL8282 | 0.87 | SOST (0.61) | TYMSSOSTFPGSKDM4EMEN1 | |
| Dihydrofolic Acid SCHEMBL12136386 | 0.87 | SOST (0.61) | TYMSSOSTFPGSKDM4EMEN1 | |
| Dihydrofolic Acid SCHEMBL27589172 | 0.87 | SOST (0.61) | TYMSSOSTFPGSKDM4EMEN1 | |
| Dihydrofolic Acid SCHEMBL8281 | 0.87 | SOST (0.61) | TYMSSOSTFPGSKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106103698-B | Chemically defined cell culture medium additives | 汉阳大学校产学协力团 | 2020-08-21 | — | — | CN | claimed |
| US-20170009199-A1 | CHEMICALLY DEFINED CELL CULTURE MEDIA ADDITIVE | IUCF-HYU (INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY) (KR) | 2017-01-12 | — | — | US | claimed |
| US-11186817-B2 | Chemically defined cell culture media additive | IUCF-HYU (INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY) (KR) | 2021-11-30 | — | — | US | disclosed |
| CN-106103698-B | Chemically defined cell culture medium additives | 汉阳大学校产学协力团 | 2020-08-21 | — | — | CN | disclosed |
| US-20170009199-A1 | CHEMICALLY DEFINED CELL CULTURE MEDIA ADDITIVE | IUCF-HYU (INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY) (KR) | 2017-01-12 | — | — | US | disclosed |
| WO-2015137640-A1 | CHEMICAL COMPOSITION CELL CULTURE MEDIUM ADDITIVES | 한양대학교 산학협력단 | 2015-09-17 | — | — | WO | disclosed |
| EP-1578698-B1 | STABILIZED AQUEOUS FOLIC ACID PREPARATION AND PROCESS FOR PROVIDING THE SAME | DOSFOLAT AG (CH) | 2007-03-07 | — | — | EP | disclosed |
| CN-1714051-A | Stable aqueous folic acid formulations and methods of making the same | DOSFRA CO LTD (CH) | 2005-12-28 | — | — | CN | disclosed |
| EP-1578698-A1 | STABILIZED AQUEOUS FOLIC ACID PREPARATION AND PROCESS FOR PROVIDING THE SAME | BLUM, Holger (DE) | 2005-09-28 | — | — | EP | disclosed |
| WO-2004054936-A1 | STABILIZED AQUEOUS FOLIC ACID PREPARATION AND PROCESS FOR PROVIDING THE SAME | BLUM HOLGER (DE) | 2004-07-01 | — | — | WO | disclosed |