Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2577670 | 0.82 | SLC6A3 (0.65) | SLC6A3CYP1A2CYP3A4CYP2D6CYP2C9 | |
| Hydrochloric Acid SCHEMBL2577794 | 0.80 | SLC6A3 (0.62) | SLC6A3CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL1121660 | 0.78 | SLC6A3 (0.66) | SLC6A3CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL2577789 | 0.78 | SLC6A3 (0.61) | SLC6A3CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL1537233 | 0.78 | SLC6A3 (0.61) | SLC6A3CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL13982744 | 0.74 | SLC6A3 (1.00) | SLC6A3SLC6A4 | |
| SCHEMBL27624146 | 0.74 | SLC6A3 (0.56) | SLC6A3CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL5022083 | 0.74 | SLC6A3 (0.65) | SLC6A3CYP1A2CYP3A4CYP2C9TSHR | |
| SCHEMBL6691161 | 0.74 | SLC6A3 (0.56) | SLC6A3CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL8213237 | 0.74 | SLC6A3 (0.55) | SLC6A3CYP1A2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1503983-B1 | A PROCESS FOR THE PREPARATION OF MODAFINIL | DIPHARMA FRANCIS SRL (IT) | 2007-06-13 | — | — | EP | claimed |
| US-7057068-B2 | Process for the preparation of modafinil | DIPHARMA S.P.A. (IT) | 2006-06-06 | — | — | US | claimed |
| US-20050154063-A1 | Process for the preparation of modafinil | DIPHARMA S.P.A. (IT) | 2005-07-14 | — | — | US | claimed |
| EP-1503983-A1 | A PROCESS FOR THE PREPARATION OF MODAFINIL | Dipharma S.p.A. (IT) | 2005-02-09 | — | — | EP | claimed |
| WO-2003095423-A1 | A PROCESS FOR THE PREPARATION OF MODAFINIL | DIPHARMA S.P.A. (IT) | 2003-11-20 | — | — | WO | claimed |
| EP-1503983-B1 | A PROCESS FOR THE PREPARATION OF MODAFINIL | DIPHARMA FRANCIS SRL (IT) | 2007-06-13 | — | — | EP | disclosed |
| EP-1503983-B1 | A PROCESS FOR THE PREPARATION OF MODAFINIL | DIPHARMA FRANCIS SRL (IT) | 2007-06-13 | — | — | EP | disclosed |
| US-7057068-B2 | Process for the preparation of modafinil | DIPHARMA S.P.A. (IT) | 2006-06-06 | — | — | US | disclosed |
| US-7057068-B2 | Process for the preparation of modafinil | DIPHARMA S.P.A. (IT) | 2006-06-06 | — | — | US | disclosed |
| US-20050154063-A1 | Process for the preparation of modafinil | DIPHARMA S.P.A. (IT) | 2005-07-14 | — | — | US | disclosed |
| US-20050154063-A1 | Process for the preparation of modafinil | DIPHARMA S.P.A. (IT) | 2005-07-14 | — | — | US | disclosed |
| EP-1503983-A1 | A PROCESS FOR THE PREPARATION OF MODAFINIL | Dipharma S.p.A. (IT) | 2005-02-09 | — | — | EP | disclosed |
| EP-1503983-A1 | A PROCESS FOR THE PREPARATION OF MODAFINIL | Dipharma S.p.A. (IT) | 2005-02-09 | — | — | EP | disclosed |
| WO-2003095423-A1 | A PROCESS FOR THE PREPARATION OF MODAFINIL | DIPHARMA S.P.A. (IT) | 2003-11-20 | — | — | WO | disclosed |
| WO-2003095423-A1 | A PROCESS FOR THE PREPARATION OF MODAFINIL | DIPHARMA S.P.A. (IT) | 2003-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050154063-A1 | Process for the preparation of modafinil | SULT2A1, AADAC, SULT1A1 | SLC6A3 166/4885CYP1A2 72/4885CYP3A4 54/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.