SCHEMBL5434

SCHEMBL5434

Brc1cccc(Oc2ccccc2)c1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 2/20 0.57
TSHR P16473 1/20 0.57
MAOB P27338 4/20 0.57
PGR P06401 1/20 0.51
ABCG2 Q9UNQ0 1/20 0.50
AKR1C3 P42330 1/20 0.50
EGFR P00533 1/20 0.50
KMT2A Q03164 2/20 0.49
HDAC8 Q9BY41 1/20 0.48
FNTA P49354 1/20 0.47
FNTB P49356 1/20 0.47
MAPT P10636 2/20 0.47
CHEK1 O14757 1/20 0.47
KDR P35968 1/20 0.47
CYP1A2 P05177 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
CASP3 P42574 1/20 0.47
HTT P42858 1/20 0.47
SENP7 Q9BQF6 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30020579 1.00 LTA4H (0.57) LTA4HTSHRMAOBPGRABCG2
SCHEMBL9817938 0.98 MAOB (0.55) LTA4HTSHRMAOBPGRABCG2
SCHEMBL7265752 0.98 MAOB (0.55) LTA4HTSHRMAOBPGRABCG2
SCHEMBL3839157 0.93 ALDH1A1 (0.54) LTA4HTSHRMAOBPGREGFR
SCHEMBL3838974 0.93 ALDH1A1 (0.54) LTA4HTSHRMAOBPGREGFR
SCHEMBL457828 0.93 MAOB (0.54) MAOBPGRABCG2EGFRKMT2A
SCHEMBL3838956 0.91 SMN1; SMN2 (0.58) LTA4HTSHRMAOBPGREGFR
SCHEMBL3842164 0.90 MAOB (0.52) MAOBABCG2EGFRKMT2AMAPT
SCHEMBL3840708 0.88 MAOB (0.55) LTA4HTSHRMAOBPGREGFR
SCHEMBL30633275 0.88 MAOB (0.55) LTA4HTSHRMAOBPGREGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 284 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118518884-A Functionalized magnetic microsphere and application thereof in troponin immunodetection 山东交通学院 2024-08-20 CN claimed
CN-118084852-A Spiro [ 9H-fluorene-9, 9' - [9H ] xanthene ] organic photoelectric material, and preparation method and application thereof 河南省科学院化学研究所有限公司 2024-05-28 CN claimed
US-12583818-B2 Compound, preparation method thereof, and use thereof DAEGU-GYEONGBUK MEDICAL INNOVATION FOUNDATION (KR) 2026-03-24 US disclosed
EP-4103557-B1 MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2026-02-18 EP disclosed
US-12502378-B2 Monoacylglycerol lipase modulators for use in autism spectrum disorders JANSSEN PHARMACEUTICA NV (BE) 2025-12-23 US disclosed
US-12473315-B2 Polycyclic aromatic compound KWANSEI GAKUIN EDUCATIONAL FOUNDATION (JP) 2025-11-18 US disclosed
US-20250304571-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF SUZHOU KEEN THERAPEUTICS CO., LTD. (CN) 2025-10-02 US disclosed
EP-4384165-B1 MONOACYLGLYCEROL LIPASE MODULATORS FOR USE IN AUTISM SPECTRUM DISORDERS JANSSEN PHARMACEUTICA NV (BE) 2025-07-09 EP disclosed
EP-4565588-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF Suzhou Keen Therapeutics Co., Ltd. (CN) 2025-06-11 EP disclosed
EP-4402221-B1 BORONIC HETEROCYCLIC COMPOUNDS FOR ORGANIC ELECTROLUMINESCENT DEVICES MERCK PATENT GMBH (DE) 2025-05-07 EP disclosed
US-12247004-B2 2-amino-N-(amino-oxo-aryl-lambda6-sulfanylidene)acetamide compounds and their therapeutic use Oxford Drug Design Limited (GB) 2025-03-11 US disclosed
WO-1985004651-A1 IMPROVEMENTS RELATING TO PESTICIDES NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) 1985-10-24 WO disclosed
EP-0074008-B1 PROCESS FOR PRODUCING ALPHA-ARYLALKANOIC ACID ESTERS TAISHO PHARMACEUTICAL CO. LTD (JP) 1984-10-10 EP disclosed
EP-0110671-A1 Preparation of optically active alpha-arylalkanoic acids and precursors thereof SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) 1984-06-13 EP disclosed
US-4433160-A Process for producing α-arylalkanoic acid ester TAISHO PHARMACEUTICAL COMPANY, LTD. (JP) 1984-02-21 US disclosed
EP-0074008-A2 Process for producing alpha-arylalkanoic acid esters TAISHO PHARMACEUTICAL CO. LTD (JP) 1983-03-16 EP disclosed
US-4162366-A INSECTICIDES FMC CORPORATION (US) 1979-07-24 US disclosed
US-4152455-A PYRETHROID CARBOXYLIC ACID MOIETY FMC CORPORATION (US) 1979-05-01 US disclosed
US-4124370-A Diphenyl ethers for tobacco sucker control ROHM AND HAAS COMPANY (US) 1978-11-07 US disclosed
US-3939084-A Functional fluid compositions containing substituted pyrimidines MONSANTO COMPANY (US) 1976-02-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12247004-B2 2-amino-N-(amino-oxo-aryl-lambda6-sulfanylidene)acetamide compounds and their therapeutic use AARS1, ASNS, GARS1 LTA4H 679/4885TSHR 2064/4885MAOB 1604/4885
US-12583818-B2 Compound, preparation method thereof, and use thereof TYRO3, TH, SRMS LTA4H 1459/4885TSHR 565/4885MAOB 422/4885
US-12473315-B2 Polycyclic aromatic compound PAH, ALK, AOC2 LTA4H 4030/4885TSHR 4594/4885MAOB 372/4885
US-12502378-B2 Monoacylglycerol lipase modulators for use in autism spectrum disorders LIPC, LPL, MGLL LTA4H 222/4885TSHR 3000/4885MAOB 62/4885
US-20250304571-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF VHL, BRCA1, TERT LTA4H 669/4885TSHR 4739/4885MAOB 857/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.