Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC3 | O15438 | 2/20 | 0.72 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.72 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.72 |
| ▸ | SLCO1B3 | Q9NPD5 | 2/20 | 0.72 |
| ▸ | SLCO1B1 | Q9Y6L6 | 2/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5512476 | 0.90 | HMGCR (0.74) | ABCC3ABCC4ABCB11SLCO1B3SLCO1B1 | |
| SCHEMBL5525274 | 0.90 | HMGCR (0.73) | ABCC3ABCC4ABCB11SLCO1B3SLCO1B1 | |
| SCHEMBL5424116 | 0.88 | HMGCR (0.79) | ABCC3ABCC4ABCB11SLCO1B3SLCO1B1 | |
| SCHEMBL14452214 | 0.85 | HMGCR (0.58) | ABCC3ABCC4ABCB11SLCO1B3SLCO1B1 | |
| SCHEMBL14605736 | 0.85 | HMGCR (0.69) | ABCC3ABCC4ABCB11SLCO1B3SLCO1B1 | |
| Atorvastatin SCHEMBL5077148 | 0.84 | ABCB11 (0.98) | ABCC3ABCC4ABCB11SLCO1B3SLCO1B1 | |
| SCHEMBL6761197 | 0.84 | ABCB11 (0.98) | ABCC3ABCC4ABCB11SLCO1B3SLCO1B1 | |
| Atorvastatin SCHEMBL3919496 | 0.84 | ABCB11 (0.97) | ABCC3ABCC4ABCB11SLCO1B3SLCO1B1 | |
| Atorvastatin SCHEMBL7037659 | 0.83 | ABCB11 (1.00) | ABCC3ABCC4ABCB11SLCO1B3SLCO1B1 | |
| Atorvastatin SCHEMBL5072672 | 0.83 | ABCB11 (1.00) | ABCC3ABCC4ABCB11SLCO1B3SLCO1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7250444-B2 | Pyrrole-based HMG-CoA reductase inhibitors | PFIZER INC. (US) | 2007-07-31 | — | — | US | disclosed |
| US-20060287378-A1 | Novel pyrroles and imidazoles | WARNER-LAMBERT COMPANY LLC | 2006-12-21 | — | — | US | disclosed |
| US-20050043364-A1 | Novel pyrrole-based HMG-CoA reductase inhibitors | KENNEDY ROBERT MICHAEL (US) | 2005-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043364-A1 | Novel pyrrole-based HMG-CoA reductase inhibitors | HMGCR, DHCR7, HSD17B12 | ABCC3 2120/4885ABCC4 2887/4885ABCB11 981/4885 |
| US-20060287378-A1 | Novel pyrroles and imidazoles | PPIP5K2, PPIE, PPOX | ABCC3 3742/4885ABCC4 4089/4885ABCB11 3458/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.