SCHEMBL560783

SCHEMBL560783

COc1c(Br)cccc1CO

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
CA2 P00918 1/20 0.39
CA4 P22748 1/20 0.39
IDO1 P14902 2/20 0.38
ALDH1A1 P00352 3/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
KDM4E B2RXH2 2/20 0.38
MAPK1 P28482 1/20 0.38
MAPT P10636 1/20 0.38
HTR2A P28223 2/20 0.37
LMNA P02545 1/20 0.36
HPGD P15428 1/20 0.36
HTR2C P28335 1/20 0.36
PDCD1 Q15116 2/20 0.36
CD274 Q9NZQ7 2/20 0.36
TDP1 Q9NUW8 1/20 0.36
NQO2 P16083 1/20 0.36
GABRA1 P14867 1/20 0.35
GABRB2 P47870 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL129790 0.85 ALDH1A1 (0.46) MEN1KMT2ACA2CA4IDO1
SCHEMBL286889 0.85 MEN1 (0.41) MEN1KMT2ACA2IDO1ALDH1A1
SCHEMBL11145069 0.82 MEN1 (0.40) MEN1KMT2ACA2IDO1ALDH1A1
SCHEMBL23536830 0.82 GABRA1 (0.52) MEN1KMT2AIDO1ALDH1A1SMN1; SMN2
SCHEMBL1364220 0.82 MEN1 (0.41) MEN1KMT2ACA2CA4IDO1
SCHEMBL31172578 0.82 CA2 (0.41) MEN1KMT2ACA2CA4ALDH1A1
SCHEMBL30525679 0.82 MEN1 (0.41) MEN1KMT2ACA2CA4IDO1
SCHEMBL16953890 0.81 GABRA1 (0.38) MEN1KMT2AIDO1ALDH1A1SMN1; SMN2
SCHEMBL560920 0.80 IDO1 (0.42) MEN1KMT2AIDO1ALDH1A1MAPT
SCHEMBL129805 0.80 ALDH1A1 (0.38) MEN1KMT2ACA2CA4IDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114181144-B Fluorobiphenyl methyl resorcinol ether derivative, preparation method and application thereof 浙江工业大学 2023-04-04 CN disclosed
US-20230062049-A1 METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS ALLERGAN, INC. 2023-03-02 US disclosed
CN-108368090-B Compounds as immunomodulators 百时美施贵宝公司 2022-04-12 CN disclosed
CN-114181144-A Fluorobiphenyl methyl resorcinol ether derivative, preparation method and application thereof 浙江工业大学 2022-03-15 CN disclosed
US-20200330428-A1 METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS ALLERGAN INC (US) 2020-10-22 US disclosed
US-10745382-B2 Compounds useful as immunomodulators BRISTOL-MYERS SQUIBB COMPANY (US) 2020-08-18 US disclosed
US-10316035-B2 Triazolopyridine inhibitors of myeloperoxidase BRISTOL-MYERS SQUIBB COMPANY (US) 2019-06-11 US disclosed
US-20180344692-A1 METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS ALLERGAN INC (US) 2018-12-06 US disclosed
US-20180244671-A1 TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE BRISTOL-MEYERS SQUIBB COMPANY (US) 2018-08-30 US disclosed
EP-3362443-A1 COMPOUNDS USEFUL AS IMMUNOMODULATORS Bristol-Myers Squibb Company (US) 2018-08-22 EP disclosed
US-20090306398-A1 METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS ALLERGAN, INC. (US) 2009-12-10 US disclosed
US-20090306398-A1 METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS ALLERGAN, INC. (US) 2009-12-10 US disclosed
US-20090306398-A1 METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS ALLERGAN, INC. (US) 2009-12-10 US disclosed
US-20090306161-A1 METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS ALLERGAN, INC. (US) 2009-12-10 US disclosed
US-20090306161-A1 METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS ALLERGAN, INC. (US) 2009-12-10 US disclosed
US-20080194650-A1 ARYL FLUOROETHYL UREAS ACTING AS ALPHA 2 ADRENERGIC AGENTS ALLERGHAN, INC. 2008-08-14 US disclosed
US-20080194650-A1 ARYL FLUOROETHYL UREAS ACTING AS ALPHA 2 ADRENERGIC AGENTS ALLERGHAN, INC. 2008-08-14 US disclosed
US-20080194650-A1 ARYL FLUOROETHYL UREAS ACTING AS ALPHA 2 ADRENERGIC AGENTS ALLERGHAN, INC. 2008-08-14 US disclosed
US-6476021-B1 Compounds having cGMP-PDE inhibitory effect MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2002-11-05 US disclosed
EP-1048666-A1 NOVEL COMPOUNDS HAVING cGMP-PDE INHIBITORY EFFECT MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 2000-11-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090306161-A1 METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS ADRB2, ADRA2C, ADRA2A MEN1 3787/4885KMT2A 3926/4885CA2 1162/4885
US-10316035-B2 Triazolopyridine inhibitors of myeloperoxidase EPX, MPO, SERPINB1 MEN1 4533/4885KMT2A 1655/4885CA2 1240/4885
US-20230062049-A1 METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS ADRB2, ADRA2A, ADRA2C MEN1 3477/4885KMT2A 3972/4885CA2 1491/4885
US-20180244671-A1 TRIAZOLOPYRIDINE INHIBITORS OF MYELOPEROXIDASE EPX, MPO, SERPINB1 MEN1 4533/4885KMT2A 1655/4885CA2 1240/4885
US-20090306398-A1 METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS ADRB2, ADRA2C, ADRA2A MEN1 3787/4885KMT2A 3926/4885CA2 1162/4885
US-10745382-B2 Compounds useful as immunomodulators CD74, HLA-DRB1, CD47 MEN1 1857/4885KMT2A 4121/4885CA2 4677/4885
US-20200330428-A1 METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS ADRB2, ADRA2A, ADRA2C MEN1 3477/4885KMT2A 3972/4885CA2 1491/4885
US-20080194650-A1 ARYL FLUOROETHYL UREAS ACTING AS ALPHA 2 ADRENERGIC AGENTS ADRB2, ADRA2C, ADRA2A MEN1 3899/4885KMT2A 1150/4885CA2 4291/4885
US-20180344692-A1 METHODS OF TREATING ALPHA ADRENERGIC MEDIATED CONDITIONS ADRB2, ADRA2A, ADRA2C MEN1 3477/4885KMT2A 3972/4885CA2 1491/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.