Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.82 |
| ▸ | LMNA | P02545 | 4/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.76 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | AIP | O00170 | 1/20 | 0.51 |
| ▸ | SGTA | O43765 | 1/20 | 0.51 |
| ▸ | TOMM70 | O94826 | 1/20 | 0.51 |
| ▸ | STIP1 | P31948 | 1/20 | 0.51 |
| ▸ | PPP5C | P53041 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10042805 | 0.93 | LMNA (0.74) | ALDH1A1LMNASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL10042806 | 0.87 | ALDH1A1 (0.63) | ALDH1A1LMNASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL7003055 | 0.75 | AIP (0.74) | ALDH1A1LMNASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL18180597 | 0.70 | L3MBTL1 (0.66) | ALDH1A1LMNASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL13126361 | 0.70 | MAPK8 (0.65) | ALDH1A1LMNASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL8012604 | 0.69 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2KDM4EMAPTRAB9A | |
| SCHEMBL31541275 | 0.69 | ALDH1A1 (1.00) | ALDH1A1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL7005515 | 0.68 | L3MBTL1 (0.65) | ALDH1A1LMNASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL14825129 | 0.68 | ALDH1A1 (0.64) | ALDH1A1LMNASMN1; SMN2KDM4EHTT | |
| SCHEMBL13126363 | 0.68 | MAPK8 (1.00) | ALDH1A1LMNASMN1; SMN2KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9045474-B2 | Compounds and compositions for mitigating tissue damage and lethality | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-06-02 | — | — | US | disclosed |
| US-20130231518-A1 | COMPOUNDS AND COMPOSITIONS FOR MITIGATING TISSUE DAMAGE AND LETHALITY | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-09-05 | — | — | US | disclosed |
| EP-2601191-A2 | COMPOUNDS AND COMPOSITIONS FOR MITIGATING TISSUE DAMAGE AND LETHALITY | The Regents of the University of California (US) | 2013-06-12 | — | — | EP | disclosed |
| WO-2012018932-A2 | COMPOUNDS AND COMPOSITIONS FOR MITIGATING TISSUE DAMAGE AND LETHALITY | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-02-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130231518-A1 | COMPOUNDS AND COMPOSITIONS FOR MITIGATING TISSUE DAMAGE AND LETHALITY | CASP3, L3MBTL4, L3MBTL3 | ALDH1A1 955/4885LMNA 260/4885SMN1; SMN2 215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.