Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.50 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL569976 | 0.93 | ALDH1A1 (0.82) | LMNAALDH1A1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL10042806 | 0.83 | ALDH1A1 (0.63) | LMNAALDH1A1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL7003055 | 0.71 | AIP (0.74) | LMNAALDH1A1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL10042833 | 0.71 | ALDH1A1 (0.43) | LMNAALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL18180597 | 0.69 | L3MBTL1 (0.66) | LMNAALDH1A1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL13126361 | 0.68 | MAPK8 (0.65) | LMNAALDH1A1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL7005515 | 0.67 | L3MBTL1 (0.65) | LMNAALDH1A1SMN1; SMN2KDM4EMEN1 | |
| SCHEMBL12231196 | 0.67 | LIMK2 (0.52) | LMNAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL8289662 | 0.67 | ALDH1A1 (0.68) | LMNAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL8288650 | 0.66 | ALDH1A1 (0.68) | LMNAALDH1A1SMN1; SMN2KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160030404-A1 | Therapeutic Agents and Methods for the Treatment of DNA Repair Deficiency Disorders | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2016-02-04 | — | — | US | disclosed |
| US-9045474-B2 | Compounds and compositions for mitigating tissue damage and lethality | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-06-02 | — | — | US | disclosed |
| US-20130231518-A1 | COMPOUNDS AND COMPOSITIONS FOR MITIGATING TISSUE DAMAGE AND LETHALITY | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-09-05 | — | — | US | disclosed |
| WO-2012018932-A2 | COMPOUNDS AND COMPOSITIONS FOR MITIGATING TISSUE DAMAGE AND LETHALITY | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-02-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130231518-A1 | COMPOUNDS AND COMPOSITIONS FOR MITIGATING TISSUE DAMAGE AND LETHALITY | CASP3, L3MBTL4, L3MBTL3 | LMNA 260/4885ALDH1A1 955/4885SMN1; SMN2 215/4885 |
| US-20160030404-A1 | Therapeutic Agents and Methods for the Treatment of DNA Repair Deficiency Disorders | OGG1, ERCC4, UNG | LMNA 425/4885ALDH1A1 675/4885SMN1; SMN2 765/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.