SCHEMBL6007162

SCHEMBL6007162

Cc1cccc(F)c1B(O)O

nearest known ligand 0.48

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ACHE P22303 3/20 0.48
ALDH1A1 P00352 1/20 0.39
CYP1A2 P05177 1/20 0.35
CYP2A6 P11509 1/20 0.35
TRPA1 O75762 2/20 0.34
CES2 O00748 1/20 0.34
CES1 P23141 1/20 0.34
ATM Q13315 1/20 0.34
HDAC4 P56524 1/20 0.34
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
CA7 P43166 1/20 0.33
CA9 Q16790 1/20 0.33
ERN1 O75460 1/20 0.33
TSHR P16473 1/20 0.33
HTR1A P08908 1/20 0.33
SLC6A2 P23975 1/20 0.33
SLC6A4 P31645 1/20 0.33
SCN8A Q9UQD0 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29427089 1.00 ACHE (0.48) ACHEALDH1A1CYP1A2CYP2A6TRPA1
SCHEMBL61913 0.85 ALDH1A1 (0.50) ACHEALDH1A1CYP1A2CYP2A6TRPA1
SCHEMBL28221318 0.83 ALDH1A1 (0.48) ACHEALDH1A1CYP1A2CYP2A6TRPA1
SCHEMBL20694978 0.83 ALDH1A1 (0.48) ACHEALDH1A1CYP1A2CYP2A6TRPA1
SCHEMBL146988 0.83 CES2 (0.42) ACHECES2CES1CA7ERN1
SCHEMBL24426723 0.83 ACHE (0.44) ACHEALDH1A1CYP1A2CYP2A6TRPA1
Magnesium Chloride Anhydrous SCHEMBL20694943 0.76 ALDH1A1 (0.42) ACHEALDH1A1CYP1A2CYP2A6TRPA1
SCHEMBL31155098 0.76 ALDH1A1 (0.42) ACHEALDH1A1CYP1A2CYP2A6TRPA1
SCHEMBL28679857 0.76 CES2 (0.33) ACHECES2CES1ERN1
Magnesium Chloride Anhydrous SCHEMBL20694920 0.74 CES2 (0.36) ALDH1A1CES2CES1ERN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 115 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12630566-B2 KRas G12D inhibitors Mirati Therapeutics, Inc. (US) 2026-05-19 US disclosed
US-12516059-B2 Pyrazolopyridine compounds and uses thereof INCYTE CORPORATION (US) 2026-01-06 US disclosed
US-12466815-B2 Carboxamide compounds and uses thereof INCYTE CORPORATION (US) 2025-11-11 US disclosed
WO-2025224168-A1 ARYL SULFONE AND SULFANONE DERIVATIVES AS OREXIN RECEPTOR MODULATORS IDORSIA PHARMACEUTICALS LTD (CH) 2025-10-30 WO disclosed
US-12384778-B2 Pyrazolopyridine compounds and uses thereof INCYTE CORPORATION (US) 2025-08-12 US disclosed
EP-4587014-A2 C5AR1 ANTAGONISTS AND USES THEREOF Vanqua Bio, Inc. (US) 2025-07-23 EP disclosed
US-12264159-B2 Functionalized heterocycles as antiviral agents ENANTA PHARMACEUTICALS, INC. (US) 2025-04-01 US disclosed
US-20250059207-A1 6,6-FUSED HETEROCYCLIC COMPOUNDS AS METTL3 INHIBITORS 858 THERAPEUTICS, INC. 2025-02-20 US disclosed
US-20250042862-A1 AROMATIC HETEROCYCLIC COMPOUND AND APPLICATION THEREOF SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) 2025-02-06 US disclosed
US-20240383889-A1 PYRAZOLOPYRIDINE COMPOUNDS AND USES THEREOF INCYTE CORPORATION 2024-11-21 US disclosed
US-20170001997-A1 OXEPAN-2-YL-PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS OF USE GENENTECH, INC. (US) 2017-01-05 US disclosed
US-20160213652-A1 Cyclic Ether Pyrazol-4-YL-Heterocyclyl-Carboxamide Compounds And Methods Of Use GENENTECH, INC. (US) 2016-07-28 US disclosed
US-9328106-B2 Cyclic ether pyrazol-4-yl-heterocyclyl-carboxamide compounds and methods of use GENENTECH, INC. (US) 2016-05-03 US disclosed
WO-2015140189-A1 OXEPAN-2-YL-PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS OF USE F. HOFFMANN-LA ROCHE AG (CH) 2015-09-24 WO disclosed
WO-2015140196-A1 INHIBITORS OF THE WNT SIGNALLING PATHWAYS BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2015-09-24 WO disclosed
EP-2900657-A1 CYCLIC ETHER PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS OF USE F. Hoffmann-La Roche AG (CH) 2015-08-05 EP disclosed
WO-2014170842-A2 SUBSTITUTED ALKYL CARBOXYLIC ACID DERIVATIVES AS GPR AGONISTS Piramal Enterprises Limited (IN) 2014-10-23 WO disclosed
EP-2738172-A1 New bicyclic compounds as crac channel modulators Almirall, S.A. (ES) 2014-06-04 EP disclosed
US-20140088117-A1 CYCLIC ETHER PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS OF USE GENENTECH, INC. (US) 2014-03-27 US disclosed
WO-2006051410-A1 AZABENZOXAZOLES FOR THE TREATMENT OF CNS DISORDERS PFIZER INC. (US) 2006-05-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12384778-B2 Pyrazolopyridine compounds and uses thereof PDXK, PCK1, PGK1 ACHE 2916/4885ALDH1A1 2205/4885CYP1A2 1509/4885
US-20240383889-A1 PYRAZOLOPYRIDINE COMPOUNDS AND USES THEREOF PDXK, PCK1, PGK1 ACHE 2916/4885ALDH1A1 2205/4885CYP1A2 1509/4885
US-20250059207-A1 6,6-FUSED HETEROCYCLIC COMPOUNDS AS METTL3 INHIBITORS METTL3, METTL16, TPMT ACHE 4589/4885ALDH1A1 1686/4885CYP1A2 3808/4885
US-12630566-B2 KRas G12D inhibitors KRAS, NRAS, HRAS ACHE 4802/4885ALDH1A1 1816/4885CYP1A2 4159/4885
US-20250042862-A1 AROMATIC HETEROCYCLIC COMPOUND AND APPLICATION THEREOF KDM1B, KDM1A, KDM3B ACHE 1116/4885ALDH1A1 165/4885CYP1A2 184/4885
US-20160213652-A1 Cyclic Ether Pyrazol-4-YL-Heterocyclyl-Carboxamide Compounds And Methods Of Use PIM1, PIM2, PIM3 ACHE 4812/4885ALDH1A1 3026/4885CYP1A2 1557/4885
US-20170001997-A1 OXEPAN-2-YL-PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS OF USE PIM1, PIM2, PIM3 ACHE 4657/4885ALDH1A1 2155/4885CYP1A2 1422/4885
US-20140088117-A1 CYCLIC ETHER PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS OF USE PIM1, PIM2, PIM3 ACHE 4812/4885ALDH1A1 3026/4885CYP1A2 1557/4885
US-12466815-B2 Carboxamide compounds and uses thereof PCK1, PHKG2, PHKG1 ACHE 3525/4885ALDH1A1 2561/4885CYP1A2 2080/4885
US-12264159-B2 Functionalized heterocycles as antiviral agents HCCS, HAVCR2, HDGF ACHE 4193/4885ALDH1A1 2352/4885CYP1A2 222/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.