Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pyrophosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 known ✓ | P00915 | 2/20 | 0.37 |
| ▸ | CA4 known ✓ | P22748 | 2/20 | 0.37 |
| ▸ | FDPS known ✓ | P14324 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CA5A | P35218 | 2/20 | 0.37 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.37 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | BTN3A1 | O00481 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrophosphoric Acid SCHEMBL16611 | 1.00 | LMNA (0.38) | LMNACA1CA4CA5ACA5B | |
| Pyrophosphoric Acid SCHEMBL378579 | 1.00 | LMNA (0.38) | LMNACA1CA4CA5ACA5B | |
| Pyrophosphoric Acid SCHEMBL14126194 | 1.00 | LMNA (0.38) | LMNACA1CA4CA5ACA5B | |
| Pyrophosphoric Acid SCHEMBL1354726 | 1.00 | LMNA (0.38) | LMNACA1CA4CA5ACA5B | |
| Pyrophosphoric Acid SCHEMBL2387459 | 1.00 | LMNA (0.38) | LMNACA1CA4CA5ACA5B | |
| Pyrophosphoric Acid SCHEMBL23537582 | 1.00 | LMNA (0.38) | LMNACA1CA4CA5ACA5B | |
| Pyrophosphoric Acid SCHEMBL22749765 | 0.95 | LMNA (0.35) | LMNACA1CA4CA5ACA5B | |
| Pyrophosphoric Acid SCHEMBL21712339 | 0.95 | LMNA (0.35) | LMNACA1CA4CA5ACA5B | |
| Pyrophosphoric Acid SCHEMBL23537579 | 0.95 | LMNA (0.35) | LMNACA1CA4CA5ACA5B | |
| Pyrophosphoric Acid SCHEMBL20699882 | 0.95 | LMNA (0.35) | LMNACA1CA4CA5ACA5B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220133607-A1 | Oral Care Composition | COLGATE-PALMOLIVE COMPANY (US) | 2022-05-05 | — | — | US | claimed |
| US-20190209448-A1 | An Oral Care Composition | COLGATE-PALMOLIVE COMPANY (US) | 2019-07-11 | — | — | US | claimed |
| EP-3461262-A1 | AN ORAL CARE COMPOSITION | Colgate-Palmolive Company (US) | 2019-04-03 | — | — | EP | claimed |
| WO-2017222548-A1 | AN ORAL CARE COMPOSITION | COLGATE-PALMOLIVE COMPANY (US) | 2017-12-28 | — | — | WO | claimed |
| CN-105534866-A | Preparation method of multiple-effect toothpaste capable of removing stains and conducting maintenance | CHEN WEIYU | 2016-05-04 | — | — | CN | claimed |
| WO-2022182101-A1 | NON-ERODIBLE TEETH WHITENING COMPOSITION HAVING HIGH PEROXIDE CONTENT | 주식회사 엘지생활건강 | 2022-09-01 | — | — | WO | disclosed |
| CN-112844304-A | Sodium pyrophosphate modified water purification sludge/zeolite composite adsorbent and preparation method and application thereof | 苏州科技大学 | 2021-05-28 | — | — | CN | disclosed |
| CN-105534866-A | Preparation method of multiple-effect toothpaste capable of removing stains and conducting maintenance | CHEN WEIYU | 2016-05-04 | — | — | CN | disclosed |
| US-20060183888-A1 | Pyrrolysine synthesis and modification | NIH - DEITR | 2006-08-17 | — | — | US | disclosed |
| US-20060166319-A1 | Charging tRNA with pyrrolysine | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2006-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060183888-A1 | Pyrrolysine synthesis and modification | PTMS, QPCTL, DNPEP | CA1 4007/4885CA4 4405/4885FDPS 614/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.