Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 1/20 | 0.54 |
| ▸ | CNR1 | P21554 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.47 |
| ▸ | CASP2 | P42575 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6940499 | 0.95 | NAAA (0.54) | NAAACNR1TSHRDNM1CASP2 | |
| SCHEMBL9717404 | 0.95 | TSHR (0.56) | NAAACNR1TSHRDNM1CASP2 | |
| SCHEMBL14984046 | 0.92 | NAAA (0.63) | NAAACNR1TSHRDNM1CASP2 | |
| SCHEMBL14984043 | 0.92 | NAAA (0.57) | NAAACNR1TSHRDNM1CASP2 | |
| SCHEMBL21559869 | 0.92 | NAAA (0.50) | NAAACNR1TSHRDNM1CASP2 | |
| SCHEMBL9717412 | 0.92 | NAAA (0.56) | NAAACNR1TSHRDNM1CASP2 | |
| SCHEMBL9754512 | 0.90 | NAAA (0.55) | NAAACNR1TSHRDNM1CASP2 | |
| SCHEMBL12834799 | 0.90 | NAAA (0.65) | NAAACNR1TSHRDNM1CASP2 | |
| SCHEMBL679044 | 0.90 | CNR1 (0.52) | NAAACNR1FAAHMEN1KMT2A | |
| SCHEMBL7776009 | 0.88 | CNR1 (0.49) | NAAACNR1TSHRDNM1CASP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4549010-A | Bioerodible poly(ortho ester) thermoplastic elastomer from diketene diacetal | MERCK & CO., INC. (US) | 1985-10-22 | — | — | US | claimed |
| US-20230219881-A1 | Synthesis of Spermidine, Spermine, and Free Bases Thereof | Compound Solutions Inc. (US) | 2023-07-13 | — | — | US | disclosed |
| US-20230219881-A1 | Synthesis of Spermidine, Spermine, and Free Bases Thereof | Compound Solutions Inc. (US) | 2023-07-13 | — | — | US | disclosed |
| US-20210252156-A1 | METHODS OF TREATING NAUSEA UTILIZING SEMI-SOLID DELIVERY VEHICLE COMPOSITIONS COMPRISING GRANISETRON | HERON THERAPEUTICS INC (US) | 2021-08-19 | — | — | US | disclosed |
| EP-3834817-A1 | SEMI-SOLID DELIVERY VEHICLE AND PHARMACEUTICAL COMPOSITIONS | Heron Therapeutics, Inc. (US) | 2021-06-16 | — | — | EP | disclosed |
| US-20200405866-A1 | METHODS OF TREATING NAUSEA UTILIZING SEMI-SOLID DELIVERY VEHICLE COMPOSITIONS COMPRISING GRANISETRON | HERON THERAPEUTICS, INC. | 2020-12-31 | — | — | US | disclosed |
| EP-3424492-B1 | SEMI-SOLID DELIVERY VECHICLE AND PHARMACEUTICAL COMPOSITIONS | HERON THERAPEUTICS INC (US) | 2020-05-27 | — | — | EP | disclosed |
| US-10357570-B2 | Methods of treating nausea utilizing semi-solid delivery vehicle compositions comprising granisetron | HERON THERAPEUTICS, INC. (US) | 2019-07-23 | — | — | US | disclosed |
| EP-3424492-A1 | SEMI-SOLID DELIVERY VECHICLE AND PHARMACEUTICAL COMPOSITIONS | Heron Therapeutics, Inc. (US) | 2019-01-09 | — | — | EP | disclosed |
| US-20180339052-A1 | METHODS OF TREATING NAUSEA UTILIZING SEMI-SOLID DELIVERY VEHICLE COMPOSITIONS COMPRISING GRANISETRON | HERCULES CAPITAL, INC., AS AGENT | 2018-11-29 | — | — | US | disclosed |
| US-20020176844-A1 | Bioerodible polyorthoesters containing hydrogen bonding groups | AP PHARMA, INC. | 2002-11-28 | — | — | US | disclosed |
| WO-2002092061-A1 | BIORODIBLE POLY(ORTHOESTERS) FROM DIOXOLANE-BASED DIKETENE ACETALS | A.P. PHARMA, INC. (US) | 2002-11-21 | — | — | WO | disclosed |
| WO-2002092655-A1 | BIOERODIBLE POLY(ORTHOESTERS) CONTAINING HYDROGEN BONDING GROUPS | A.P. PHARMA, INC. (US) | 2002-11-21 | — | — | WO | disclosed |
| US-20020168336-A1 | Bioerodible polyorthoesters from dioxolane-based diketene acetals | HERON THERAPEUTICS, INC. (F/K/A A.P. PHARMA, INC.) | 2002-11-14 | — | — | US | disclosed |
| US-20020037300-A1 | Semi-solid delivery vehicle and pharmaceutical compositions | HERON THERAPEUTICS, INC. (F/K/A A.P. PHARMA, INC.) | 2002-03-28 | — | — | US | disclosed |
| WO-2001085139-A2 | SEMI-SOLID DELIVERY VEHICLE AND PHARMACEUTICAL COMPOSITIONS | ADVANCED POLYMER SYSTEMS, INC. (US) | 2001-11-15 | — | — | WO | disclosed |
| EP-0733045-B1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2001-08-16 | — | — | EP | disclosed |
| EP-0733045-A1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1995015952-A1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1995-06-15 | — | — | WO | disclosed |
| US-4549010-A | Bioerodible poly(ortho ester) thermoplastic elastomer from diketene diacetal | MERCK & CO., INC. (US) | 1985-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020037300-A1 | Semi-solid delivery vehicle and pharmaceutical compositions | LIPA, CEL, SORD | NAAA 4009/4885CNR1 2847/4885TSHR 4120/4885 |
| US-20200405866-A1 | METHODS OF TREATING NAUSEA UTILIZING SEMI-SOLID DELIVERY VEHICLE COMPOSITIONS COMPRISING GRANISETRON | LPXN, CRH, NTSR1 | NAAA 1440/4885CNR1 151/4885TSHR 2469/4885 |
| US-20020176844-A1 | Bioerodible polyorthoesters containing hydrogen bonding groups | PLOD3, HAO2, CD44 | NAAA 3230/4885CNR1 4631/4885TSHR 2763/4885 |
| US-20210252156-A1 | METHODS OF TREATING NAUSEA UTILIZING SEMI-SOLID DELIVERY VEHICLE COMPOSITIONS COMPRISING GRANISETRON | LPXN, CRH, NTSR1 | NAAA 1440/4885CNR1 151/4885TSHR 2469/4885 |
| US-10357570-B2 | Methods of treating nausea utilizing semi-solid delivery vehicle compositions comprising granisetron | LPXN, CRH, NTSR1 | NAAA 1440/4885CNR1 151/4885TSHR 2469/4885 |
| US-20180339052-A1 | METHODS OF TREATING NAUSEA UTILIZING SEMI-SOLID DELIVERY VEHICLE COMPOSITIONS COMPRISING GRANISETRON | LPXN, CRH, NTSR1 | NAAA 1440/4885CNR1 151/4885TSHR 2469/4885 |
| US-20230219881-A1 | Synthesis of Spermidine, Spermine, and Free Bases Thereof | SRM, SMS, SMOX | NAAA 222/4885CNR1 4679/4885TSHR 3458/4885 |
| US-20020168336-A1 | Bioerodible polyorthoesters from dioxolane-based diketene acetals | HAAO, HAO2, HAO1 | NAAA 1714/4885CNR1 3654/4885TSHR 3700/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.