Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | CES2 | O00748 | 1/20 | 0.53 |
| ▸ | CES1 | P23141 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PLAU | P00749 | 1/20 | 0.50 |
| ▸ | ELANE | P08246 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.49 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL335504 | 0.85 | LTA4H (0.57) | LTA4HUSP2TP53CES2CES1 | |
| SCHEMBL6581234 | 0.81 | LTA4H (0.53) | LTA4HUSP2TP53CES2CES1 | |
| SCHEMBL571063 | 0.81 | USP2 (0.69) | USP2TP53CES2CES1NPC1 | |
| SCHEMBL28366589 | 0.81 | LTA4H (0.53) | LTA4HUSP2TP53CES2CES1 | |
| SCHEMBL6986510 | 0.81 | RAB9A (0.67) | LTA4HCES2CES1NPC1SMN1; SMN2 | |
| SCHEMBL28303440 | 0.79 | SMN1; SMN2 (0.84) | LTA4HUSP2TP53CES2CES1 | |
| SCHEMBL8672567 | 0.79 | CES1 (0.52) | CES2CES1ALDH1A1MAPTTDP1 | |
| SCHEMBL8496806 | 0.79 | ALDH1A1 (0.50) | LTA4HUSP2TP53CES2CES1 | |
| SCHEMBL8057053 | 0.78 | SMN1; SMN2 (0.61) | LTA4HUSP2TP53CES2CES1 | |
| SCHEMBL9595063 | 0.77 | PLAU (0.58) | LTA4HUSP2TP53CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 312 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11332489-B2 | Process for preparing imetelstat | GERON CORPORATION (US) | 2022-05-17 | — | — | US | claimed |
| EP-3652187-B1 | IMPROVED PROCESS FOR PREPARING IMETELSTAT | GERON CORP (US) | 2021-09-15 | — | — | EP | claimed |
| US-20200369702-A1 | Improved Process for Preparing Imetelstat | BIOPHARMA CREDIT PLC [COLLATERAL AGENT] (GB) | 2020-11-26 | — | — | US | claimed |
| EP-3652187-A1 | IMPROVED PROCESS FOR PREPARING IMETELSTAT | GERON CORPORATION (US) | 2020-05-20 | — | — | EP | claimed |
| CN-110891961-A | Improved process for the preparation of isomestat (imetelstat) | 美国杰龙生物医药公司 | 2020-03-17 | — | — | CN | claimed |
| WO-2019011829-A1 | IMPROVED PROCESS FOR PREPARING IMETELSTAT | JANSSEN PHARMACEUTICA NV (BE) | 2019-01-17 | — | — | WO | claimed |
| US-20140142253-A1 | Dithiolane Based Thiol Modifier For Labeling and Stronger Immobilization of Bio-Molecules On Solid Surfaces | CHEMGENES CORPORATION (US) | 2014-05-22 | — | — | US | claimed |
| US-8541569-B2 | Phosphoramidites for synthetic RNA in the reverse direction, efficient RNA synthesis and convenient introduction of 3'-end ligands, chromophores and modifications of synthetic RNA | CHEMGENES CORPORATION (US) | 2013-09-24 | — | — | US | claimed |
| WO-2013126034-A1 | SYNTHESIS OF HIGH PURITY DMT-C3-DISULFIDE PHOSPHORAMIDITE | CHEMGENES CORPORATION (US) | 2013-08-29 | — | — | WO | claimed |
| US-20110137010-A1 | PHOSPHORAMIDITES FOR SYNTHETIC RNA IN THE REVERSE DIRECTION, EFFICIENT RNA SYNTHESIS AND CONVENIENT INTRODUCTION OF 3'-END LIGANDS, CHROMOPHORES AND MODIFICATIONS OF SYNTHETIC RNA | CHEMGENES CORPORATION (US) | 2011-06-09 | — | — | US | claimed |
| EP-0270651-A1 | NOVEL DEOXYRIBONUCLEOSIDE PHOSPHORAMIDITES AND THEIR USE FOR THE PREPARATION OF OLIGONUCLEOTIDES. | CALIFORNIA INST OF TECHN (US) | 1988-06-15 | — | — | EP | claimed |
| WO-1988000201-A1 | NOVEL DEOXYRIBONUCLEOSIDE PHOSPHORAMIDITES AND THEIR USE FOR THE PREPARATION OF OLIGONUCLEOTIDES | CALIFORNIA INSTITUTE OF TECHNOLOGY, INC. (US) | 1988-01-14 | — | — | WO | claimed |
| EP-0061746-B1 | PHOSPHORAMIDITE COMPOUNDS AND THEIR USE IN PRODUCING OLIGONUCLEOTIDES | UNIVERSITY PATENTS, INC. (US) | 1985-03-20 | — | — | EP | claimed |
| US-4500707-A | Nucleosides useful in the preparation of polynucleotides | UNIVERSITY PATENTS, INC. (US) | 1985-02-19 | — | — | US | claimed |
| EP-0035255-B1 | PROCESS FOR REMOVING TRITYL BLOCKING GROUPS FROM 5'-O TRITYL NUCLEOSIDES AND OLIGONUCLEOTIDES | UNIVERSITY PATENTS, INC. (US) | 1984-05-30 | — | — | EP | claimed |
| EP-0097805-A2 | Nucleoside phosphite compounds | UNIVERSITY PATENTS, INC. (US) | 1984-01-11 | — | — | EP | claimed |
| US-4415732-A | STORAGE-STABLE NUCLEOSIDES; POLYNUCLEOTIDE SYNTHESIS | UNIVERSITY PATENTS, INC. (US) | 1983-11-15 | — | — | US | claimed |
| EP-0061746-A1 | Phosphoramidite compounds and their use in producing oligonucleotides | UNIVERSITY PATENTS, INC. (US) | 1982-10-06 | — | — | EP | claimed |
| EP-0035719-A2 | Process for producing modified inorganic polymers, their use in producing polynucleotides, and a reagent useful in these processes | UNIVERSITY PATENTS, INC. (US) | 1981-09-16 | — | — | EP | claimed |
| EP-0035255-A1 | Process for removing trityl blocking groups from 5'-O trityl nucleosides and oligonucleotides | UNIVERSITY PATENTS, INC. (US) | 1981-09-09 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140142253-A1 | Dithiolane Based Thiol Modifier For Labeling and Stronger Immobilization of Bio-Molecules On Solid Surfaces | PTMS, SPOUT1, SRMS | LTA4H 3176/4885USP2 2017/4885TP53 2061/4885 |
| US-11332489-B2 | Process for preparing imetelstat | RNGTT, TERT, TRMT1L | LTA4H 1346/4885USP2 2713/4885TP53 1229/4885 |
| US-20200369702-A1 | Improved Process for Preparing Imetelstat | RNGTT, TERT, TRMT1L | LTA4H 1589/4885USP2 2798/4885TP53 1167/4885 |
| US-20110137010-A1 | PHOSPHORAMIDITES FOR SYNTHETIC RNA IN THE REVERSE DIRECTION, EFFICIENT RNA SYNTHESIS AND CONVENIENT INTRODUCTION OF 3'-END LIGANDS, CHROMOPHORES AND MODIFICATIONS OF SYNTHETIC RNA | NSUN3, RNGTT, NOP2 | LTA4H 3740/4885USP2 4791/4885TP53 3153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.