Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.58 |
| ▸ | CES2 | O00748 | 3/20 | 0.48 |
| ▸ | CES1 | P23141 | 3/20 | 0.48 |
| ▸ | CYP1B1 | Q16678 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 2/20 | 0.47 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.47 |
| ▸ | ABHD5 | Q8WTS1 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | F3 | P13726 | 2/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | TNKS | O95271 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3753532 | 0.87 | HDAC1 (0.67) | HDAC1CES2CES1CYP1B1MAPT | |
| SCHEMBL3753530 | 0.87 | HDAC1 (0.67) | HDAC1CES2CES1CYP1B1MAPT | |
| SCHEMBL27905641 | 0.85 | CES2 (0.68) | HDAC1CES2CES1CYP1B1MAPT | |
| SCHEMBL6311364 | 0.83 | HDAC1 (0.62) | HDAC1CES2CES1CYP1B1MAPT | |
| Benzil SCHEMBL27348338 | 0.81 | CES2 (0.70) | HDAC1CES2CES1CYP1B1MAPT | |
| Benzoyl Formic Acid SCHEMBL1702148 | 0.80 | CES2 (0.68) | CES2CES1MAPTRECQLALDH1A1 | |
| SCHEMBL1927729 | 0.79 | HDAC1 (0.67) | HDAC1CES2CES1CYP1B1MAPT | |
| SCHEMBL1927732 | 0.79 | HDAC1 (0.67) | HDAC1CES2CES1CYP1B1MAPT | |
| SCHEMBL8437189 | 0.79 | HDAC1 (0.67) | HDAC1CES2CES1CYP1B1MAPT | |
| SCHEMBL11545296 | 0.79 | HDAC1 (0.67) | HDAC1CES2CES1CYP1B1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6960667-B2 | Fluorescent maleimides and uses thereof | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 2005-11-01 | — | — | US | disclosed |
| US-20030189191-A1 | Fluorescent maleimides and uses thereof | KUNIMOTO KAZUHIKO (JP) | 2003-10-09 | — | — | US | disclosed |
| US-6508957-B2 | Ultraviolet fluorescent material for void detection and for preparation of scintillators, films, luminescent solar energy collectors, organic electroluminescent devices, printing inks, electrophotographic toners | CIBA SPECIALTY CHEMICALS CORPORATION | 2003-01-21 | — | — | US | disclosed |
| EP-1216285-A1 | FLUORESCENT MALEIMIDES AND USES THEREOF | Ciba SC Holding AG (CH) | 2002-06-26 | — | — | EP | disclosed |
| US-20020065422-A1 | Fluorescent maleimides and uses thereof | KUNIMOTO KAZUHIKO (JP) | 2002-05-30 | — | — | US | disclosed |
| US-6258954-B1 | ELECTROLUMINESCENCE; DETECTION VOIDS | CIBA SPECIALTY CHEMICALS CORP. | 2001-07-10 | — | — | US | disclosed |
| WO-2001019939-A1 | FLUORESCENT MALEIMIDES AND USES THEREOF | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2001-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020065422-A1 | Fluorescent maleimides and uses thereof | IK, PAH, MYO1F | HDAC1 1580/4885CES2 2780/4885CES1 3843/4885 |
| US-20030189191-A1 | Fluorescent maleimides and uses thereof | CBR1, CBR3, MT-CO2 | HDAC1 2742/4885CES2 288/4885CES1 239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.