Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Thioinosine Monophosphate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 known ✓ | P30542 | 2/20 | 0.68 |
| ▸ | P2RY1 known ✓ | P47900 | 8/20 | 0.65 |
| ▸ | P2RY2 known ✓ | P41231 | 3/20 | 0.64 |
| ▸ | PDE4D known ✓ | Q08499 | 1/20 | 0.64 |
| ▸ | PDE3A known ✓ | Q14432 | 1/20 | 0.64 |
| ▸ | P2RY11 | Q96G91 | 3/20 | 0.65 |
| ▸ | ENPP1 | P22413 | 3/20 | 0.65 |
| ▸ | SRC | P12931 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | DNPH1 | O43598 | 2/20 | 0.64 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.64 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.64 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.64 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.64 |
| ▸ | LDHA | P00338 | 1/20 | 0.64 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.64 |
| ▸ | FBP1 | P09467 | 1/20 | 0.64 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.64 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Thioinosine Monophosphate SCHEMBL15810629 | 0.91 | DNPH1 (0.77) | ADORA1P2RY1P2RY11P2RY2SRC | |
| Thioinosine Monophosphate SCHEMBL29746215 | 0.91 | DNPH1 (0.77) | ADORA1P2RY1P2RY11P2RY2SRC | |
| Thioinosine Monophosphate SCHEMBL379366 | 0.91 | DNPH1 (0.77) | ADORA1P2RY1P2RY11P2RY2SRC | |
| Thioinosine Monophosphate SCHEMBL379365 | 0.91 | DNPH1 (0.77) | ADORA1P2RY1P2RY11P2RY2SRC | |
| SCHEMBL29556100 | 0.88 | ADORA1 (0.69) | ADORA1P2RY1P2RY11ENPP1P2RY2 | |
| SCHEMBL316941 | 0.88 | ADORA1 (0.69) | ADORA1P2RY1P2RY11ENPP1P2RY2 | |
| Water SCHEMBL23878697 | 0.88 | ADORA1 (0.68) | ADORA1P2RY1P2RY11ENPP1P2RY2 | |
| Adenosine Phosphate SCHEMBL353218 | 0.88 | P2RY1 (0.83) | ADORA1P2RY1P2RY11ENPP1P2RY2 | |
| SCHEMBL1030877 | 0.88 | ADORA1 (0.68) | ADORA1P2RY1P2RY11ENPP1P2RY2 | |
| Potassium Ion SCHEMBL247204 | 0.88 | ADORA1 (0.68) | ADORA1P2RY1P2RY11ENPP1P2RY2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867199-B2 | Dinucleoside polyphosphate compositions and their therapeutic use | INSPIRE PHARMACEUTICALS, INC. (US) | 2005-03-15 | — | — | US | disclosed |
| US-20030207825-A1 | Dinucleoside polyphosphate compositions and their therapeutic use | Outdoor Wireless Networks LLC | 2003-11-06 | — | — | US | disclosed |
| US-6555675-B2 | Dinucleoside polyphosphates which facilitate secretory mechanisms, i.e. increasing the hydration of mucus secretions, stimulating the production of mucins and increasing ciliary beat frequency to facilitate clearance | INSPIRE PHARMACEUTICALS, INC. | 2003-04-29 | — | — | US | disclosed |
| US-20020103158-A1 | Dinucleoside polyphosphate compositions and their therapeutic use as purinergic receptor agonists | INSPIRE PHARMACEUTICALS, INC. | 2002-08-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020103158-A1 | Dinucleoside polyphosphate compositions and their therapeutic use as purinergic receptor agonists | P2RY1, P2RY10, P2RX3 | ADORA1 48/4885P2RY1 1/4885P2RY2 5/4885 |
| US-20030207825-A1 | Dinucleoside polyphosphate compositions and their therapeutic use | P2RY1, P2RY10, P2RY11 | ADORA1 24/4885P2RY1 1/4885P2RY2 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.