Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.59 |
| ▸ | HTR3B | O95264 | 4/20 | 0.59 |
| ▸ | HTR3A | P46098 | 4/20 | 0.59 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.59 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.59 |
| ▸ | HTR5A | P47898 | 1/20 | 0.59 |
| ▸ | ADRB1 | P08588 | 9/20 | 0.51 |
| ▸ | HTR1A | P08908 | 3/20 | 0.50 |
| ▸ | HTR1D | P28221 | 1/20 | 0.50 |
| ▸ | HTR1B | P28222 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 2/20 | 0.46 |
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29979524 | 1.00 | HTR3E (0.59) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL1537900 | 0.88 | HTR3E (0.57) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Propionic Acid SCHEMBL6610077 | 0.86 | ALDH1A1 (0.46) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL3342144 | 0.85 | TERT (0.52) | HTTAHRCMA1TYR | |
| Tert-Butyl Formate SCHEMBL28781853 | 0.84 | HTR1A (0.44) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL5382950 | 0.84 | TERT (0.53) | HTTAHRCMA1TYR | |
| SCHEMBL444108 | 0.82 | GHSR (0.52) | TP53CYP1A2HTTAHRCMA1 | |
| SCHEMBL5097444 | 0.81 | HTR3A (0.57) | HTR3AHTT | |
| SCHEMBL9396666 | 0.79 | HTR3E (0.51) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL7291426 | 0.79 | ALDH1A1 (0.50) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230124361-A1 | SMALL MOLECULE STING ANTAGONISTS | CURADEV PHARMA PVT. LTD. (IN) | 2023-04-20 | — | — | US | disclosed |
| US-20230124361-A1 | SMALL MOLECULE STING ANTAGONISTS | CURADEV PHARMA PVT. LTD. (IN) | 2023-04-20 | — | — | US | disclosed |
| CN-115151304-A | Small molecule interferon gene stimulating factor (STING) antagonists | 库拉德夫制药私人有限公司 | 2022-10-04 | — | — | CN | disclosed |
| WO-2021161230-A1 | SMALL MOLECULE STING ANTAGONISTS | CURADEV PHARMA PVT. LTD. (IN) | 2021-08-19 | — | — | WO | disclosed |
| US-20120220604-A1 | PIPERAZINYL-ALKYL-BENZOIMIDAZOL-2-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | NEUROSEARCH A/S (DK) | 2012-08-30 | — | — | US | disclosed |
| EP-1299380-B1 | INDOLE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | LUNDBECK & CO AS H (DK) | 2004-06-09 | — | — | EP | disclosed |
| EP-1299384-B1 | INDOLE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | LUNDBECK & CO AS H (DK) | 2004-03-24 | — | — | EP | disclosed |
| US-20030232822-A1 | Indole derivatives useful for the treatment of CNS disorders | H. LUNDBECK A/S (DE) | 2003-12-18 | — | — | US | disclosed |
| CN-1446216-A | Indole derivatives for the treatment of CNS disorders | LUNDEBECK AS H (DK) | 2003-10-01 | — | — | CN | disclosed |
| US-20030162792-A1 | Indole derivatives useful for the treatment of CNS disorders | H. LUNDBECK A/S (DK) | 2003-08-28 | — | — | US | disclosed |
| CN-1439004-A | Indole derivatives for the treatment of central nervous system disorders | LUNDBECK & CO AS H (DK) | 2003-08-27 | — | — | CN | disclosed |
| EP-1299380-A1 | INDOLE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | H. LUNDBECK A/S (DK) | 2003-04-09 | — | — | EP | disclosed |
| EP-1299384-A1 | INDOLE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | H. Lundbeck A/S (DK) | 2003-04-09 | — | — | EP | disclosed |
| WO-2002000645-A1 | INDOLE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | H. LUNDBECK A/S (DK) | 2002-01-03 | — | — | WO | disclosed |
| WO-2001098298-A1 | INDOLE DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS | H. LUNDBECK A/S (DK) | 2001-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120220604-A1 | PIPERAZINYL-ALKYL-BENZOIMIDAZOL-2-ONE DERIVATIVES AND THEIR USE AS MONOAMINE NEUROTRANSMITTER RE-UPTAKE INHIBITORS | SLC18A2, SLC6A2, SLC18A3 | HTR3E 121/4885HTR3B 35/4885HTR3A 36/4885 |
| US-20230124361-A1 | SMALL MOLECULE STING ANTAGONISTS | STING1, CGAS, MAVS | HTR3E 1935/4885HTR3B 1454/4885HTR3A 3131/4885 |
| US-20030162792-A1 | Indole derivatives useful for the treatment of CNS disorders | CHRM1, SLC6A3, HTR3C | HTR3E 71/4885HTR3B 35/4885HTR3A 28/4885 |
| US-20030232822-A1 | Indole derivatives useful for the treatment of CNS disorders | CHRM1, TPH1, CHRNA6 | HTR3E 80/4885HTR3B 62/4885HTR3A 38/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.