Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPB1 | P15086 | 2/20 | 0.34 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.34 |
| ▸ | NOS1 | P29475 | 2/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29086267 | 0.86 | CPB1 (0.32) | CPB1CPB2NOS1NOS3NOS2 | |
| SCHEMBL5828857 | 0.81 | TDP1 (0.32) | CPB1CPB2 | |
| SCHEMBL29478490 | 0.81 | ALDH1A1 (0.38) | — | |
| SCHEMBL20569401 | 0.79 | TDP1 (0.32) | NOS1NOS3NOS2 | |
| SCHEMBL1937378 | 0.78 | APLNR (0.30) | — | |
| SCHEMBL30874619 | 0.78 | NOS1 (0.35) | NOS1NOS3NOS2 | |
| SCHEMBL30831230 | 0.77 | NOS1 (0.30) | NOS1NOS3NOS2 | |
| SCHEMBL9108794 | 0.75 | PRKCA (0.33) | NOS1NOS3NOS2 | |
| SCHEMBL12527313 | 0.73 | TDP1 (0.33) | — | |
| SCHEMBL5828855 | 0.71 | CTH (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11612662-B2 | Multi-arm polymeric prodrug conjugates of pemetrexed-based compounds | NEKTAR THERAPEUTICS (US) | 2023-03-28 | — | — | US | disclosed |
| US-20200323992-A1 | MULTI-ARM POLYMERIC PRODRUG CONJUGATES OF PEMETREXED-BASED COMPOUNDS | NEKTAR THERAPEUTICS (US) | 2020-10-15 | — | — | US | disclosed |
| US-10736969-B2 | Multi-arm polymeric prodrug conjugates of pemetrexed-based compounds | NEKTAR THERAPEUTICS (US) | 2020-08-11 | — | — | US | disclosed |
| EP-2654795-B1 | MULTI-ARM POLYMERIC PRODRUG CONJUGATES OF PEMETREXED-BASED COMPOUNDS | NEKTAR THERAPEUTICS (US) | 2018-03-07 | — | — | EP | disclosed |
| US-20150209440-A1 | CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE | CERULEAN PHARMA INC. (US) | 2015-07-30 | — | — | US | disclosed |
| WO-2015057847-A1 | CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS | CERULEAN PHARMA INC. (US) | 2015-04-23 | — | — | WO | disclosed |
| EP-2817345-A1 | CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS | Cerulean Pharma Inc. (US) | 2014-12-31 | — | — | EP | disclosed |
| US-20140296322-A1 | CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE | CERULEAN PHARMA INC. (US) | 2014-10-02 | — | — | US | disclosed |
| US-20140037573-A1 | CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS | CERULEAN PHARMA INC (US) | 2014-02-06 | — | — | US | disclosed |
| US-20130338175-A1 | Multi-Arm Polymeric Prodrug Conjugates of Pemetrexed-Based Compounds | NEKTAR THERAPEUTICS (US) | 2013-12-19 | — | — | US | disclosed |
| EP-2654795-A1 | MULTI-ARM POLYMERIC PRODRUG CONJUGATES OF PEMETREXED-BASED COMPOUNDS | Nektar Therapeutics (US) | 2013-10-30 | — | — | EP | disclosed |
| WO-2013126564-A1 | CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS | CERULEAN PHARMA INC. (US) | 2013-08-29 | — | — | WO | disclosed |
| EP-2605799-A2 | CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS | Cerulean Pharma Inc. (US) | 2013-06-26 | — | — | EP | disclosed |
| US-20120302622-A1 | CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS | CERULEAN PHARMA INC. (US) | 2012-11-29 | — | — | US | disclosed |
| US-20120225129-A1 | CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS | CERULEAN PHARMA INC. (US) | 2012-09-06 | — | — | US | disclosed |
| WO-2012088282-A1 | MULTI-ARM POLYMERIC PRODRUG CONJUGATES OF PEMETREXED-BASED COMPOUNDS | NEKTAR THERAPEUTICS (US) | 2012-06-28 | — | — | WO | disclosed |
| WO-2012024526-A2 | CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS | CERULEAN PHARMA INC. (US) | 2012-02-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140296322-A1 | CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE | CD44, DIS3, POLN | CPB1 1232/4885CPB2 1577/4885NOS1 4685/4885 |
| US-11612662-B2 | Multi-arm polymeric prodrug conjugates of pemetrexed-based compounds | PAICS, MTHFD2, MTHFD1 | CPB1 1914/4885CPB2 2438/4885NOS1 4766/4885 |
| US-20140037573-A1 | CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS | SYNCRIP, EXOSC5, EXOSC9 | CPB1 1427/4885CPB2 1902/4885NOS1 4678/4885 |
| US-20120302622-A1 | CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS | SYNCRIP, EXOSC5, EXOSC9 | CPB1 1427/4885CPB2 1902/4885NOS1 4678/4885 |
| US-10736969-B2 | Multi-arm polymeric prodrug conjugates of pemetrexed-based compounds | PAICS, MTHFD2, MTHFD1 | CPB1 1914/4885CPB2 2438/4885NOS1 4766/4885 |
| US-20200323992-A1 | MULTI-ARM POLYMERIC PRODRUG CONJUGATES OF PEMETREXED-BASED COMPOUNDS | PAICS, MTHFD2, MTHFD1 | CPB1 1914/4885CPB2 2438/4885NOS1 4766/4885 |
| US-20130338175-A1 | Multi-Arm Polymeric Prodrug Conjugates of Pemetrexed-Based Compounds | PAICS, PARP6, PARP1 | CPB1 2349/4885CPB2 2816/4885NOS1 4839/4885 |
| US-20150209440-A1 | CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS OF USE | CD44, DIS3, POLN | CPB1 1232/4885CPB2 1577/4885NOS1 4685/4885 |
| US-20120225129-A1 | CONJUGATES, PARTICLES, COMPOSITIONS, AND RELATED METHODS | SYNCRIP, EXOSC5, EXOSC9 | CPB1 1427/4885CPB2 1902/4885NOS1 4678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.