Sugi Predict

Sugi Predict / Compounds / SCHEMBL6789474

SCHEMBL6789474

SCHEMBL6789474

O=Cc1ccc(-c2ccc(C(F)(F)F)c(Cl)c2)o1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 6/20 0.51
▸ KDM4E B2RXH2 5/20 0.51
▸ LMNA P02545 2/20 0.51
▸ POLB P06746 3/20 0.47
▸ LDHA P00338 1/20 0.46
▸ LDHB P07195 1/20 0.46
▸ HAO1 Q9UJM8 1/20 0.46
▸ SMN1; SMN2 Q16637 1/20 0.45
▸ TDP1 Q9NUW8 2/20 0.44
▸ L3MBTL1 Q9Y468 1/20 0.43
▸ MAPT P10636 2/20 0.43
▸ MEN1 O00255 1/20 0.41
▸ KMT2A Q03164 1/20 0.41
▸ GSK3A P49840 3/20 0.41
▸ GSK3B P49841 3/20 0.41
▸ SIRT2 Q8IXJ6 1/20 0.40
▸ IGF1R P08069 2/20 0.40
▸ CYP2E1 P05181 1/20 0.40
▸ CYP3A4 P08684 1/20 0.40
▸ CYP2D6 P10635 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1806721 0.88 KDM4E (0.52) ALDH1A1KDM4ELMNAPOLBLDHA
SCHEMBL30861661 0.88 KDM4E (0.52) ALDH1A1KDM4ELMNAPOLBLDHA
SCHEMBL1806482 0.81 ALDH1A1 (0.57) ALDH1A1KDM4ELMNAPOLBLDHA
SCHEMBL17802293 0.79 ALDH1A1 (0.48) ALDH1A1KDM4ELMNAPOLBLDHA
SCHEMBL2321202 0.77 KDM4E (0.58) ALDH1A1KDM4ELMNAPOLBLDHA
SCHEMBL17802295 0.76 ALDH1A1 (0.50) ALDH1A1KDM4ELMNAPOLBLDHA
SCHEMBL1807252 0.76 AR (0.50) ALDH1A1KDM4ELMNALDHALDHB
SCHEMBL7317023 0.76 ALDH1A1 (0.48) ALDH1A1KDM4ELMNAPOLBLDHA
SCHEMBL2158436 0.74 KDM4E (0.66) ALDH1A1KDM4ELMNAPOLBLDHA
SCHEMBL15331986 0.73 LDHA (0.68) ALDH1A1KDM4ELMNAPOLBLDHA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3226858-B1 IMIDAZOLE-BASED ANTIMICROBIAL AGENTS PROCOMCURE BIOTECH GMBH (AT) 2021-02-03 — — EP disclosed
US-10456379-B2 Imidazole-based antimicrobial agents PROCOMCURE BIOTECH GMBH (AT) 2019-10-29 — — US disclosed
US-10322110-B2 Imidazole-based antimicrobial agents PROCOMCURE BIOTECH GMBH (AT) 2019-06-18 — — US disclosed
US-10314820-B2 Imidazole-based heterocyclic compounds PROCOMCURE BIOTECH GMBH (AT) 2019-06-11 — — US disclosed
US-20170368032-A1 Imidazole-Based Antimicrobial Agents PROCOMCURE BIOTECH GMBH (AT) 2017-12-28 — — US disclosed
US-20170340613-A1 Novel Imidazole-Based Heterocyclic Compounds PROCOMCURE BIOTECH GMBH (AT) 2017-11-30 — — US disclosed
US-20170334887-A1 Imidazole-Based Antimicrobial Agents PROCOMCURE BIOTECH GMBH (AT) 2017-11-23 — — US disclosed
EP-3226858-A1 IMIDAZOLE-BASED ANTIMICROBIAL AGENTS Procomcure Biotech GmbH (AT) 2017-10-11 — — EP disclosed
WO-2016087618-A1 IMIDAZOLE-BASED ANTIMICROBIAL AGENTS PROCOMCURE BIOTECH GMBH (AT) 2016-06-09 — — WO disclosed
WO-2016087616-A1 IMIDAZOLE-BASED ANTIMICROBIAL AGENTS PROCOMCURE BIOTECH GMBH (AT) 2016-06-09 — — WO disclosed
WO-2016087615-A1 NOVEL IMIDAZOLE-BASED HETEROCYCLIC COMPOUNDS PROCOMCURE BIOTECH GMBH (AT) 2016-06-09 — — WO disclosed
US-20040147573-A1 Metalloproteinase inhibitors ASTRAZENECA AB (SE) 2004-07-29 — — US disclosed
CN-1509274-A Metallo proteinase inhibitors — 2004-06-30 — — CN disclosed
CN-1509275-A Metalloproteinase inhibitors — 2004-06-30 — — CN disclosed
US-20040110809-A1 Metalloproteinase inhibitors ASTRAZENECA AB (SE) 2004-06-10 — — US disclosed
EP-1370536-A1 METALLOPROTEINASE INHIBITORS AstraZeneca AB (SE) 2003-12-17 — — EP disclosed
EP-1370538-A1 METALLOPROTEINASE INHIBITORS AstraZeneca AB (SE) 2003-12-17 — — EP disclosed
WO-2002074752-A1 METALLOPROTEINASE INHIBITORS ASTRAZENECA AB (SE) 2002-09-26 — — WO disclosed
WO-2002074750-A1 METALLOPROTEINASE INHIBITORS ASTRAZENECA AB (SE) 2002-09-26 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040110809-A1 Metalloproteinase inhibitors MMP9, MMP2, MMP3 ALDH1A1 294/4885KDM4E 2088/4885LMNA 1493/4885
US-20170334887-A1 Imidazole-Based Antimicrobial Agents TLR5, NISCH, SLC11A2 ALDH1A1 1629/4885KDM4E 2893/4885LMNA 4548/4885
US-10456379-B2 Imidazole-based antimicrobial agents TLR5, NISCH, SLC11A2 ALDH1A1 1629/4885KDM4E 2893/4885LMNA 4548/4885
US-10322110-B2 Imidazole-based antimicrobial agents ARG1, SLC11A2, IKZF3 ALDH1A1 1211/4885KDM4E 1072/4885LMNA 4362/4885
US-20170368032-A1 Imidazole-Based Antimicrobial Agents TLR5, NISCH, SLC11A2 ALDH1A1 1629/4885KDM4E 2893/4885LMNA 4548/4885
US-20170340613-A1 Novel Imidazole-Based Heterocyclic Compounds SLC11A2, MIF, NISCH ALDH1A1 562/4885KDM4E 2876/4885LMNA 4273/4885
US-10314820-B2 Imidazole-based heterocyclic compounds MIF, SLC11A2, TLR5 ALDH1A1 370/4885KDM4E 2426/4885LMNA 4294/4885
US-20040147573-A1 Metalloproteinase inhibitors MMP12, MMP7, MMP10 ALDH1A1 1250/4885KDM4E 2227/4885LMNA 2465/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.