Sugi Predict

Sugi Predict / Compounds / SCHEMBL6854538

SCHEMBL6854538

SCHEMBL6854538

Nc1cccc(C2(C(F)(F)F)N=N2)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 2/20 0.44
▸ MAPK1 P28482 1/20 0.44
▸ ADRA2A P08913 1/20 0.43
▸ CYP3A4 P08684 1/20 0.41
▸ CASP1 P29466 1/20 0.41
▸ RECQL P46063 1/20 0.41
▸ GABRB3 P28472 5/20 0.39
▸ GABRA1 P14867 4/20 0.39
▸ GABRG2 P18507 4/20 0.39
▸ GABRB2 P47870 2/20 0.39
▸ KIF11 P52732 1/20 0.37
▸ GLA P06280 1/20 0.35
▸ POLB P06746 1/20 0.35
▸ GAA P10253 1/20 0.35
▸ KDM1A O60341 2/20 0.35
▸ PDK2 Q15119 2/20 0.35
▸ ALDH1A1 P00352 2/20 0.34
▸ CA12 O43570 1/20 0.34
▸ CA1 P00915 1/20 0.34
▸ CA2 P00918 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22587363 0.86 ADRA2A (0.49) ADRA2AGABRB3GABRA1GABRG2GABRB2
SCHEMBL586923 0.77 ADRA2A (0.43) ADRA2AGABRB3GABRA1GABRG2GABRB2
SCHEMBL3724536 0.77 ADRA2A (0.43) TSHRADRA2ACYP3A4GABRB3GABRA1
SCHEMBL2528314 0.77 GABRA1 (0.41) ADRA2AGABRB3GABRA1GABRG2GABRB2
SCHEMBL14655026 0.75 KIF11 (0.49) TSHRADRA2ACYP3A4GABRB3GABRA1
SCHEMBL80368 0.74 KIF11 (0.43) TSHRADRA2AGABRB3GABRA1GABRG2
SCHEMBL18007679 0.74 CA2 (0.50) ADRA2AGABRB3GABRA1GABRG2GABRB2
SCHEMBL24028220 0.73 TSHR (0.44) TSHRMAPK1CYP3A4CASP1RECQL
SCHEMBL30212897 0.73 TSHR (0.44) TSHRMAPK1CYP3A4CASP1RECQL
SCHEMBL19871652 0.73 TSHR (0.44) TSHRMAPK1CYP3A4CASP1RECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10005936-B2 Photoactive bioadhesive compositions NANYANG TECHNOLOGICAL UNIVERSITY (SG) 2018-06-26 — — US claimed
US-20150315434-A1 New Photoactive Bioadhesive Compositions NANYANG TECHNOLOGICAL UNIVERSITY (SG) 2015-11-05 — — US claimed
WO-2014081391-A1 NEW PHOTOACTIVE BIOADHESIVE COMPOSITIONS NANYANG TECHNOLOGICAL UNIVERSITY (SG) 2014-05-30 — — WO claimed
US-20240400502-A1 SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME UNIV QUEENSLAND (AU) 2024-12-05 — — US disclosed
EP-3416948-B1 INDACENE BEARING SULFONYLUREAS AS ANTI-INFLAMMATORY AGENTS UNIV QUEENSLAND (AU) 2024-07-24 — — EP disclosed
US-11858922-B2 Sulfonylureas and related compounds and use of same THE UNIVERSITY OF QUEENSLAND (AU) 2024-01-02 — — US disclosed
US-11845715-B2 — — 2023-12-19 — — US disclosed
US-11845715-B2 — — 2023-12-19 — — US disclosed
US-20220112159-A1 SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME UNIV QUEENSLAND (AU) 2022-04-14 — — US disclosed
EP-3888749-A1 SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME The University of Queensland (AU) 2021-10-06 — — EP disclosed
EP-3888749-A1 SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME The University of Queensland (AU) 2021-10-06 — — EP disclosed
EP-2997029-A1 SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS Glaxosmithkline LLC (US) 2016-03-23 — — EP disclosed
US-20150315434-A1 New Photoactive Bioadhesive Compositions NANYANG TECHNOLOGICAL UNIVERSITY (SG) 2015-11-05 — — US disclosed
US-20150152108-A1 SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS GLAXOSMITHKLINE LLC 2015-06-04 — — US disclosed
WO-2014186313-A1 SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS GLAXOSMITHKLINE LLC (US) 2014-11-20 — — WO disclosed
WO-2014081391-A1 NEW PHOTOACTIVE BIOADHESIVE COMPOSITIONS NANYANG TECHNOLOGICAL UNIVERSITY (SG) 2014-05-30 — — WO disclosed
US-6780980-B1 MATERIAL SURFACES WITH CARBOHYDRATES, AND BIOMEDICAL ARTICLES OR BIOSENSORS COMPRISING THE MODIFIED ARTICLES CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE S.A. (CH) 2004-08-24 — — US disclosed
EP-0484472-B1 METHOD FOR THE LIGHT-INDUCED IMMOBILIZATION OF BIOMOLECULES ON CHEMICALLY \"INERT\" SURFACES SIGRIST HANS DR (CH) 1997-07-16 — — EP disclosed
EP-0484472-A1 METHOD FOR THE LIGHT-INDUCED IMMOBILIZATION OF BIOMOLECULES ON CHEMICALLY \"INERT\" SURFACES. SIGRIST HANS (CH) 1992-05-13 — — EP disclosed
WO-1991016425-A1 METHOD FOR THE LIGHT-INDUCED IMMOBILIZATION OF BIOMOLECULES ON CHEMICALLY 'INERT' SURFACES SIGRIST HANS (CH) 1991-10-31 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10005936-B2 Photoactive bioadhesive compositions L1CAM, CDH1, PCNA TSHR 1156/4885MAPK1 2820/4885ADRA2A 1906/4885
US-20220112159-A1 SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME NLRP3, PYCARD, IAPP TSHR 3880/4885MAPK1 1463/4885ADRA2A 4140/4885
US-11845715-B2 — NLRP3, PYCARD, NOD1 TSHR 4210/4885MAPK1 2379/4885ADRA2A 4471/4885
US-20150152108-A1 SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS SIRT1, SIRT3, SIRT2 TSHR 3064/4885MAPK1 2404/4885ADRA2A 4519/4885
US-20240400502-A1 SULFONYLUREAS AND RELATED COMPOUNDS AND USE OF SAME NLRP3, PYCARD, IAPP TSHR 3880/4885MAPK1 1463/4885ADRA2A 4140/4885
US-11858922-B2 Sulfonylureas and related compounds and use of same NLRP3, NOD1, PYCARD TSHR 2656/4885MAPK1 2495/4885ADRA2A 1956/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.