Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 11/20 | 0.42 |
| ▸ | CTSL | P07711 | 4/20 | 0.41 |
| ▸ | CTSK | P43235 | 4/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MLYCD | O95822 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 2/20 | 0.37 |
| ▸ | CTSH | P09668 | 1/20 | 0.37 |
| ▸ | CTSC | P53634 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7028324 | 0.79 | CTSL (0.51) | CTSSCTSLCTSKMMP8FKBP1A | |
| SCHEMBL8690335 | 0.79 | CTSS (0.46) | CTSSCTSLCTSKMMP8FKBP1A | |
| SCHEMBL7356291 | 0.78 | FKBP1A (0.41) | CTSSCTSLCTSKMMP1MMP3 | |
| SCHEMBL7378602 | 0.76 | CTSS (0.45) | CTSSCTSLCTSKALDH1A1CTSB | |
| SCHEMBL7545314 | 0.73 | CTSS (0.62) | CTSSCTSLCTSBCTSC | |
| SCHEMBL8696245 | 0.72 | MMP2 (0.42) | CTSSCTSLCTSKALDH1A1KMT2A | |
| SCHEMBL8696240 | 0.72 | MMP2 (0.42) | CTSSCTSLCTSKALDH1A1KMT2A | |
| SCHEMBL7445245 | 0.72 | ALDH1A1 (0.57) | ALDH1A1KMT2A | |
| SCHEMBL7546891 | 0.70 | CTSS (0.60) | CTSSCTSLALDH1A1CTSBCTSC | |
| SCHEMBL6450679 | 0.69 | CTSB (0.38) | CTSSCTSLCTSKMMP9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5776718-A | Reversible protease inhibitors | ARRIS PHARMACEUTICAL CORPORATION (US) | 1998-07-07 | — | — | US | disclosed |
| EP-0817778-A1 | REVERSIBLE PROTEASE INHIBITORS | ARRIS PHARMACEUTICAL CORPORATION (US) | 1998-01-14 | — | — | EP | disclosed |
| WO-1996030353-A1 | REVERSIBLE PROTEASE INHIBITORS | ARRIS PHARMACEUTICAL CORPORATION (US) | 1996-10-03 | — | — | WO | disclosed |