Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 4/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7953684 | 0.86 | OPRL1 (0.36) | ADRB2ADRB1CYP1A2HIF1AADRA2A | |
| SCHEMBL7963395 | 0.83 | LMNA (0.44) | ADRB2ADRB1CYP1A2HIF1AADRA2A | |
| SCHEMBL7963392 | 0.81 | ADRB2 (0.35) | ADRB2ADRB1CYP1A2HIF1AADRA2A | |
| SCHEMBL7965119 | 0.80 | OPRM1 (0.39) | CYP1A2KDM4ETP53CYP2D6OPRL1 | |
| SCHEMBL7962701 | 0.78 | LTA4H (0.36) | OPRL1MEN1LMNAKMT2AOPRM1 | |
| SCHEMBL7962212 | 0.78 | ALDH1A1 (0.41) | KDM4ETP53OPRL1MEN1LMNA | |
| SCHEMBL7964943 | 0.77 | LTA4H (0.33) | OPRL1OPRM1LTA4HSLC6A2SLC6A4 | |
| SCHEMBL7965366 | 0.75 | PRMT5 (0.38) | OPRL1OPRM1LTA4H | |
| SCHEMBL7962748 | 0.74 | PDE10A (0.39) | CYP3A4OPRL1MEN1KMT2ALTA4H | |
| SCHEMBL7953304 | 0.73 | OPRL1 (0.38) | KDM4EOPRL1MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| WO-2000006166-A1 | 5-HT1F ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |