Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7964941 | 0.85 | CCR1 (0.45) | HTR1ACCR1 | |
| SCHEMBL7964944 | 0.83 | MEN1 (0.30) | — | |
| SCHEMBL7965119 | 0.79 | OPRM1 (0.39) | HTR1ADRD2DRD4HTR2ADRD3 | |
| SCHEMBL7963401 | 0.77 | ADRB2 (0.33) | LTA4HOPRL1OPRM1SLC6A2SLC6A4 | |
| SCHEMBL7962212 | 0.76 | ALDH1A1 (0.41) | HTR1ADRD2HTR2ADRD3OPRL1 | |
| SCHEMBL7962701 | 0.75 | LTA4H (0.36) | LTA4HHTR1ADRD2DRD4HTR2A | |
| SCHEMBL7962748 | 0.73 | PDE10A (0.39) | LTA4HHTR1ADRD2DRD4DRD3 | |
| SCHEMBL7953354 | 0.70 | ALPL (0.36) | HTR1ADRD2HTR2ADRD3OPRL1 | |
| Sulfuric Acid SCHEMBL7968961 | 0.70 | DRD3 (0.37) | LTA4HHTR1ADRD2DRD3 | |
| SCHEMBL7953304 | 0.70 | OPRL1 (0.38) | LTA4HHTR1AOPRL1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| WO-2000006166-A1 | 5-HT1F ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |