SCHEMBL8074582

SCHEMBL8074582

O=C([O-])C(=O)CCc1ccccc1.[Na+]

nearest known ligand 0.62

Known targets — ChEMBL curated mechanism

ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 4/20 0.62
HDAC2 Q92769 3/20 0.62
HDAC8 Q9BY41 3/20 0.62
HDAC6 Q9UBN7 3/20 0.62
HDAC3 O15379 2/20 0.62
HDAC4 P56524 2/20 0.62
HDAC7 Q8WUI4 2/20 0.62
HDAC10 Q969S8 2/20 0.62
HDAC11 Q96DB2 2/20 0.62
HDAC9 Q9UKV0 2/20 0.62
HDAC5 Q9UQL6 2/20 0.62
KEAP1 Q14145 1/20 0.61
ALDH1A1 P00352 2/20 0.57
FFAR1 O14842 2/20 0.57
PLAAT5 Q96KN8 5/20 0.56
PLAAT4 Q9UL19 5/20 0.56
TDP1 Q9NUW8 2/20 0.53
MAPK1 P28482 1/20 0.52
ADRA1A P35348 1/20 0.52
SLC6A3 Q01959 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4279627 0.86 KEAP1 (0.73) HDAC1HDAC2HDAC8HDAC6HDAC3
SCHEMBL304591 0.85 HDAC1 (0.60) HDAC1HDAC2HDAC8HDAC6HDAC3
SCHEMBL15751237 0.85 HDAC1 (0.60) HDAC1HDAC2HDAC8HDAC6HDAC3
Phenyl Propionic Acid SCHEMBL5351527 0.84 HDAC1 (0.70) HDAC1HDAC2HDAC8HDAC6HDAC3
Phenyl Propionic Acid SCHEMBL6672575 0.84 HDAC1 (0.77) HDAC1HDAC2HDAC8HDAC6HDAC3
Phenyl Propionic Acid SCHEMBL9385376 0.84 HDAC1 (0.77) HDAC1HDAC2HDAC8HDAC6HDAC3
SCHEMBL29078123 0.82 KEAP1 (0.67) HDAC1HDAC2HDAC8HDAC6HDAC3
SCHEMBL258545 0.82 KEAP1 (0.67) HDAC1HDAC2HDAC8HDAC6HDAC3
Phenyl Propionic Acid SCHEMBL6534962 0.80 HDAC1 (0.70) HDAC1HDAC2HDAC8HDAC6HDAC3
Phenyl Propionic Acid SCHEMBL7736260 0.80 HDAC1 (0.70) HDAC1HDAC2HDAC8HDAC6HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103266144-A Novel system for transferring biocatalytic reaction substrate based on high-molecular material UNIV CHINA PHARMA 2013-08-28 CN disclosed
EP-0620857-B1 SYNTHESIS OF HOMOCHIRAL 2-HYDROXY ACIDS GENZYME LTD (GB) 2000-08-02 EP disclosed
US-6033882-A DERIVED FROM LACTOBACILLUS DELBRUECKII SSP. BULGARICUS. GENZYME CORPORATION (US) 2000-03-07 US disclosed
US-5686275-A LACTATE DEHYDROGENASE GENZYME LTD. (GB) 1997-11-11 US disclosed
EP-0767832-A1 CHIRAL SYNTHESIS OF 2-HYDROXY CARBOXYLIC ACIDS WITH A DEHYDROGENASE Genzyme Limited (GB) 1997-04-16 EP disclosed
WO-1996001892-A1 CHIRAL SYNTHESIS OF 2-HYDROXY CARBOXYLIC ACIDS WITH A DEHYDROGENASE GENZYME LIMITED (GB) 1996-01-25 WO disclosed
EP-0620857-A1 SYNTHESIS OF HOMOCHIRAL 2-HYDROXY ACIDS Genzyme Limited (GB) 1994-10-26 EP disclosed
WO-1993013215-A1 SYNTHESIS OF HOMOCHIRAL 2-HYDROXY ACIDS GENZYME LIMITED (GB) 1993-07-08 WO disclosed
EP-0135846-B1 PRODUCTION OF L-AMINO ACIDS BY TRANSAMINATION GENETICS INSTITUTE, INC. (US) 1990-08-16 EP disclosed
US-4525454-A REACTING 2-KETOACID AND L-ASPARTIC ACID IN PRESENCE OF TRANSAMINASE ENZYME GENETICS INSTITUTE, INC. (US) 1985-06-25 US disclosed