Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | TACR1 | P25103 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CTSK | P43235 | 3/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8351818 | 1.00 | ALDH1A1 (0.53) | ALDH1A1TACR1MAPK1L3MBTL1SLC6A2 | |
| Hydrochloric Acid SCHEMBL30844650 | 0.98 | ALDH1A1 (0.51) | ALDH1A1TACR1MAPK1L3MBTL1SLC6A2 | |
| SCHEMBL20804457 | 0.89 | PPARA (0.53) | ALDH1A1TACR1MAPK1L3MBTL1SLC6A2 | |
| SCHEMBL21444696 | 0.87 | ALDH1A1 (0.53) | ALDH1A1TACR1MAPK1L3MBTL1SLC6A2 | |
| SCHEMBL2059140 | 0.87 | TACR1 (0.58) | ALDH1A1TACR1POLBS1PR1MAPT | |
| SCHEMBL13108402 | 0.87 | TACR1 (0.58) | ALDH1A1TACR1POLBS1PR1MAPT | |
| SCHEMBL23011779 | 0.85 | ALDH1A1 (0.51) | ALDH1A1TACR1MAPK1L3MBTL1SLC6A2 | |
| SCHEMBL7400240 | 0.85 | ALDH1A1 (0.51) | ALDH1A1TACR1MAPK1L3MBTL1SLC6A2 | |
| SCHEMBL4954521 | 0.85 | CTRB1 (0.52) | ALDH1A1TACR1MAPK1L3MBTL1SLC6A2 | |
| SCHEMBL5019111 | 0.85 | ALDH1A1 (0.51) | ALDH1A1TACR1MAPK1L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250263365-A1 | O-SUBSTITUTED SERINE DERIVATIVE PRODUCTION METHOD | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2025-08-21 | — | — | US | disclosed |
| EP-3878836-B1 | O-SUBSTITUTED SERINE DERIVATIVE PRODUCTION METHOD | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2025-07-23 | — | — | EP | disclosed |
| US-12312297-B2 | O-substituted serine derivative production method | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2025-05-27 | — | — | US | disclosed |
| CN-112969683-B | Process for the preparation of O-substituted serine derivatives | 中外制药株式会社 | 2024-05-14 | — | — | CN | disclosed |
| US-20220017456-A1 | O-SUBSTITUTED SERINE DERIVATIVE PRODUCTION METHOD | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2022-01-20 | — | — | US | disclosed |
| US-20120289471-A1 | NOVEL COMPOUNDS WITH HIGH THERAPEUTIC INDEX | SIGNATURE R&D HOLDINGS, LLC (US) | 2012-11-15 | — | — | US | disclosed |
| US-8188311-B2 | L-threonine derivatives of high therapeutic index | SIGNATURE R&D HOLDINGS, LLC (US) | 2012-05-29 | — | — | US | disclosed |
| US-8173840-B2 | Compounds with high therapeutic index | SIGNATURE R&D HOLDINGS, LLC (US) | 2012-05-08 | — | — | US | disclosed |
| US-20100069446-A1 | L-THREONINE DERIVATIVES OF HIGH THERAPEUTIC INDEX | SIGNATURE R&D HOLDINGS (US) | 2010-03-18 | — | — | US | disclosed |
| US-20100069489-A1 | L-THREONINE DERIVATIVES OF HIGH THERAPEUTIC INDEX | SIGNATURE R&D HOLDINGS (US) | 2010-03-18 | — | — | US | disclosed |
| US-7589233-B2 | L-Threonine derivatives of high therapeutic index | SIGNATURE R&D HOLDINGS, LLC (US) | 2009-09-15 | — | — | US | disclosed |
| US-5948693-A | COVALENTLY BONDING SIDE CHAIN OF SELECTED AMINO ACID TO SOLID SUPPORT VIA ACID-LABILE OR PHOTO-LABILE LINKER, PROTECTING C-TERMINUS, SYNTHESIZING POLYPEPTIDE ON N-TERMINUS, DEPROTECTING C-TERMINUS AND CYCLIZING POLYPEPTIDE | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1999-09-07 | — | — | US | disclosed |
| WO-1998046247-A1 | SOLID PHASE SYNTHESIS OF IMMUNOSUPPRESSIVE AGENTS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1998-10-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250263365-A1 | O-SUBSTITUTED SERINE DERIVATIVE PRODUCTION METHOD | STS, SMOX, TST | ALDH1A1 616/4885TACR1 2831/4885MAPK1 1834/4885 |
| US-20100069446-A1 | L-THREONINE DERIVATIVES OF HIGH THERAPEUTIC INDEX | BCAT1, AADAT, TPI1 | ALDH1A1 1176/4885TACR1 1234/4885MAPK1 2904/4885 |
| US-12312297-B2 | O-substituted serine derivative production method | STS, SMOX, TST | ALDH1A1 616/4885TACR1 2831/4885MAPK1 1834/4885 |
| US-20220017456-A1 | O-SUBSTITUTED SERINE DERIVATIVE PRODUCTION METHOD | STS, SMOX, TST | ALDH1A1 616/4885TACR1 2831/4885MAPK1 1834/4885 |
| US-20120289471-A1 | NOVEL COMPOUNDS WITH HIGH THERAPEUTIC INDEX | IL4I1, SLC7A1, GOT1 | ALDH1A1 945/4885TACR1 1277/4885MAPK1 4669/4885 |
| US-20100069489-A1 | L-THREONINE DERIVATIVES OF HIGH THERAPEUTIC INDEX | BCAT1, AADAT, TPI1 | ALDH1A1 1176/4885TACR1 1234/4885MAPK1 2904/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.