SCHEMBL8658192

SCHEMBL8658192

Cc1ccc(NC(=S)Nc2ccc(S(=O)(=O)NC(=O)c3cccc(C)c3)cc2)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.56
LMNA P02545 6/20 0.56
ALOX12 P18054 4/20 0.56
SMN1; SMN2 Q16637 4/20 0.56
MAPT P10636 3/20 0.56
HTT P42858 2/20 0.56
HPGD P15428 3/20 0.54
MEN1 O00255 1/20 0.54
KMT2A Q03164 1/20 0.54
PTGS2 P35354 3/20 0.52
EGFR P00533 1/20 0.52
GPR17 Q13304 1/20 0.52
NPC1 O15118 2/20 0.51
RAB9A P51151 2/20 0.51
TP53 P04637 1/20 0.51
STAT1 P42224 1/20 0.51
CYP1A2 P05177 1/20 0.51
CYP3A4 P08684 1/20 0.51
CYP2D6 P10635 1/20 0.51
CYP2C9 P11712 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8655317 0.94 ALDH1A1 (0.56) ALDH1A1LMNAALOX12SMN1; SMN2MAPT
SCHEMBL7770066 0.91 MAPT (0.55) ALDH1A1LMNAALOX12SMN1; SMN2MAPT
SCHEMBL7777675 0.89 LMNA (0.60) ALDH1A1LMNAALOX12SMN1; SMN2MAPT
SCHEMBL9179605 0.88 PTGS2 (0.64) MEN1KMT2APTGS2EGFRTP53
SCHEMBL7776308 0.88 MAPT (0.61) ALDH1A1LMNAALOX12SMN1; SMN2MAPT
SCHEMBL8658570 0.87 PTGS2 (0.61) ALDH1A1LMNAMAPTHPGDMEN1
SCHEMBL7774529 0.85 LMNA (0.63) ALDH1A1LMNAALOX12SMN1; SMN2MAPT
SCHEMBL7776320 0.85 ENPP2 (0.61) ALDH1A1LMNAALOX12MAPTHPGD
SCHEMBL9467745 0.84 LMNA (0.54) LMNASMN1; SMN2MAPTMEN1KMT2A
SCHEMBL7770076 0.84 RAB9A (0.56) LMNASMN1; SMN2MAPTHTTMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0699662-B1 Novel urea (thiourea) derivative and thermal recording sheet using same JUJO PAPER CO LTD (JP) 1998-10-21 EP disclosed
US-5661100-A HAVING HIGH SENSITIVITY, SUPERIOR THERMAL RESISTANCE, WATER RESISTANCE, OIL RESISTANCE NIPPON PAPER INDUSTRIES CO., LTD. (JP) 1997-08-26 US disclosed
EP-0699662-A1 Novel urea (thiourea) derivative and thermal recording sheet using same NIPPON PAPER INDUSTRIES CO., LTD. (JP) 1996-03-06 EP disclosed