SCHEMBL888368

SCHEMBL888368

[O]c1cccc2cccc([O])c12

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.53
HSD17B10 Q99714 6/20 0.53
TSHR P16473 5/20 0.53
HPGD P15428 5/20 0.53
CYP3A4 P08684 4/20 0.53
CYP1A2 P05177 2/20 0.53
CYP1A1 P04798 1/20 0.53
CYP1B1 Q16678 1/20 0.53
CES2 O00748 1/20 0.46
BCHE P06276 1/20 0.46
CES1 P23141 1/20 0.46
MCL1 Q07820 1/20 0.46
MAPK1 P28482 2/20 0.43
L3MBTL1 Q9Y468 2/20 0.43
ATM Q13315 1/20 0.43
TYMS P04818 4/20 0.42
THRB P10828 1/20 0.41
PARP1 P09874 1/20 0.40
CASP1 P29466 2/20 0.39
CASP7 P55210 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27930387 0.81 JAK2 (0.50) ALDH1A1HSD17B10TSHRHPGDCYP3A4
SCHEMBL18380189 0.81 ALDH1A1 (0.41) ALDH1A1HSD17B10TSHRHPGDCYP3A4
SCHEMBL18242692 0.81 ALDH1A1 (0.41) ALDH1A1HSD17B10TSHRHPGDCYP3A4
SCHEMBL18243082 0.81 ALDH1A1 (0.41) ALDH1A1HSD17B10TSHRHPGDCYP3A4
SCHEMBL1402322 0.81 CYP1A2 (0.44) ALDH1A1HSD17B10TSHRHPGDCYP3A4
SCHEMBL18242843 0.81 MEN1 (0.46) ALDH1A1HSD17B10TSHRHPGDCYP3A4
SCHEMBL82006 0.79 ALDH1A1 (0.54) ALDH1A1HSD17B10TSHRHPGDCYP3A4
SCHEMBL14353989 0.77 ALDH1A1 (0.58) ALDH1A1HSD17B10TSHRHPGDCYP3A4
SCHEMBL18244315 0.77 GABRA1 (0.44) ALDH1A1HSD17B10TSHRHPGDCYP3A4
SCHEMBL18242078 0.75 ALDH1A1 (0.36) ALDH1A1HSD17B10TSHRHPGDCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9499455-B2 Process for the selective dimerisation of ethylene to 1-butene IFP Energies Nouvelles (FR) 2016-11-22 US claimed
US-20240239725-A1 METHOD FOR OLIGOMERISATION IN A REACTOR COMPRISING VARIABLE-DIAMETER ZONES, INCLUDING A STEP OF RECYCLING A PRE-COOLED SOLVENT IFP Energies Nouvelles (FR) 2024-07-18 US disclosed
EP-4347542-A1 METHOD FOR OLIGOMERISATION IN A REACTOR COMPRISING VARIABLE-DIAMETER ZONES, INCLUDING A STEP OF RECYCLING A PRE-COOLED SOLVENT IFP Energies nouvelles (FR) 2024-04-10 EP disclosed
CN-117693496-A Oligomerization process in a reactor having a variable diameter zone comprising a step of recycling pre-cooled solvent IFP 新能源公司 2024-03-12 CN disclosed
CN-112533889-B Process for oligomerization in cascade with stirred gas-liquid reactor staged injection of ethylene IFP 新能源公司 2024-03-05 CN disclosed
US-20240050911-A1 METHOD FOR OLIGOMERIZATION IN A REACTOR COMPRISING A GAS/LIQUID DOUBLE DISTRIBUTOR IFP Energies Nouvelles (FR) 2024-02-15 US disclosed
CN-117120401-A Oligomerization process comprising a step of recycling pre-cooled solvent IFP 新能源公司 2023-11-24 CN disclosed
CN-114761118-B Gas/liquid oligomerization reactor having continuous zones of varying diameter IFP 新能源公司 2023-11-07 CN disclosed
CN-116997410-A Method for oligomerization in a reactor comprising a gas/liquid double distributor IFP 新能源公司 2023-11-03 CN disclosed
US-11786878-B2 Oligomerization process using a recycle of gaseous headspace IFP Energies Nouvelles (FR) 2023-10-17 US disclosed
US-20090062493-A1 LIGANDS AND CATALYST SYSTEMS THEREOF FOR THE CATALYTIC OLIGOMERIZATION OF OLEFINIC MONOMERS SHELL OIL COMPANY 2009-03-05 US disclosed
US-6903042-B2 Catalytic composition and process for oligomerizing ethylene, in particular to 1-hexene INSTITUT FRANCAIS DU PETROLE (FR) 2005-06-07 US disclosed
US-6828269-B2 Chromium compound,aryloxy compound of a magnesium, calcium, strontium and barium; hydrocarbylaluminum and aluminoxane compounds INSTITUT FRANCAIS DU PETROLE (FR) 2004-12-07 US disclosed
EP-1110930-B1 Catalytic composition and process for the oligomerisation of ethylene, to primarily 1-hexene INST FRANCAIS DU PETROLE (FR) 2003-09-10 EP disclosed
US-20030130551-A1 Catalytic composition and process for oligomerizing ethylene, in particular to1-hexene INSTITUT FRANCAIS DU PETROLE (FR) 2003-07-10 US disclosed
EP-0885656-B1 Catalytic composition and ethylene oligomerization, especially in 1-butene and/or 1-hexene INST FRANCAIS DU PETROLE (FR) 2002-01-02 EP disclosed
US-20010023281-A1 Catalytic composition and a process for oligomerizing ethylene, in particular to 1-hexene INSTITUT FRANCAIS DU PETROLE (FR) 2001-09-20 US disclosed
EP-1110930-A1 Catalytic composition and process for the oligomerisation of ethylene, to primarily 1-hexene INSTITUT FRANCAIS DU PETROLE (FR) 2001-06-27 EP disclosed
US-6031145-A A CATALYTIC COMPOSITION MIXTURE COMPRISING ONE CHROMIUM COMPOUND, ONE ARYLOXY ALUMINUM COMPOUND AND ONE HYDROCARBYL ALUMINUM COMPOUND FOR DIMERIZATION, TRIMERIZATION INSTITUT FRANCAIS DU PETROLE (FR) 2000-02-29 US disclosed
EP-0885656-A1 Catalytic composition and ethylene oligomerization, especially in 1-butene and/or 1-hexene Institut Français du Pétrole (FR) 1998-12-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090062493-A1 LIGANDS AND CATALYST SYSTEMS THEREOF FOR THE CATALYTIC OLIGOMERIZATION OF OLEFINIC MONOMERS MSMO1, BPHL, CCNL2 ALDH1A1 1490/4885HSD17B10 120/4885TSHR 2312/4885
US-20240239725-A1 METHOD FOR OLIGOMERISATION IN A REACTOR COMPRISING VARIABLE-DIAMETER ZONES, INCLUDING A STEP OF RECYCLING A PRE-COOLED SOLVENT PRPF40A, NSF, NOD2 ALDH1A1 4310/4885HSD17B10 465/4885TSHR 4442/4885
US-20240050911-A1 METHOD FOR OLIGOMERIZATION IN A REACTOR COMPRISING A GAS/LIQUID DOUBLE DISTRIBUTOR DUOX2, COASY, DUOX1 ALDH1A1 4579/4885HSD17B10 374/4885TSHR 4176/4885
US-11786878-B2 Oligomerization process using a recycle of gaseous headspace OXER1, OR51E2, PRUNE1 ALDH1A1 2004/4885HSD17B10 377/4885TSHR 3393/4885
US-20030130551-A1 Catalytic composition and process for oligomerizing ethylene, in particular to1-hexene ME1, HAO2, EXOC1 ALDH1A1 2053/4885HSD17B10 1763/4885TSHR 1700/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.