SCHEMBL8912352

SCHEMBL8912352

CCOC(=O)C(C)(C)N(C)C

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP4F2 P78329 3/20 0.42
CYP4A11 Q02928 3/20 0.42
ALDH1A1 P00352 3/20 0.42
PKM P14618 3/20 0.40
MMP8 P22894 2/20 0.40
LMNA P02545 1/20 0.40
HSD17B10 Q99714 1/20 0.40
KDM4E B2RXH2 1/20 0.39
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
ALOX15 P16050 1/20 0.39
MGAM O43451 1/20 0.39
GAA P10253 1/20 0.39
SI P14410 1/20 0.39
MGAM2 Q2M2H8 1/20 0.39
SOAT1 P35610 1/20 0.39
THRB P10828 1/20 0.38
ABCB11 O95342 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2169861 0.82 ALOX15 (0.41) CYP4F2CYP4A11ALDH1A1PKMMMP8
SCHEMBL15802691 0.82 HCAR2 (0.36) ALDH1A1LMNAHSD17B10CYP1A2CYP3A4
SCHEMBL23644313 0.82 CYP4F2 (0.40) CYP4F2CYP4A11ALDH1A1PKMMMP8
SCHEMBL27709308 0.80 CYP4F2 (0.39) CYP4F2CYP4A11ALDH1A1PKMMMP8
SCHEMBL10277380 0.79 CYP4F2 (0.41) CYP4F2CYP4A11ALDH1A1PKMMMP8
SCHEMBL11675418 0.79 CYP4F2 (0.41) CYP4F2CYP4A11ALDH1A1PKMMMP8
SCHEMBL27540559 0.77 CYP4F2 (0.40) CYP4F2CYP4A11ALDH1A1PKMMMP8
SCHEMBL22841351 0.77 PKM (0.39) CYP4F2CYP4A11ALDH1A1PKMMMP8
SCHEMBL19619691 0.76 NAAA (0.50) ALDH1A1LMNATSHR
SCHEMBL4427462 0.75 MMP8 (0.47) CYP4F2CYP4A11ALDH1A1PKMMMP8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230365608-A1 ANTIVIRAL NUCLEOSIDES AND DERIVATIVES THEREOF JANSSEN BIOPHARMA, LLC 2023-11-16 US disclosed
US-10179102-B2 Hair conditioner for wavy and curly hair KAO USA, INC. (US) 2019-01-15 US disclosed
US-20180185264-A1 HAIR CONDITIONER FOR WAVY AND CURLY HAIR KAO USA INC. 2018-07-05 US disclosed
US-9630989-B2 Dipeptide analogs for treating conditions associated with amyloid fibril formation RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) 2017-04-25 US disclosed
US-9630989-B2 Dipeptide analogs for treating conditions associated with amyloid fibril formation RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) 2017-04-25 US disclosed
US-9096645-B2 Dipeptide analogs for treating conditions associated with amyloid fibril formation RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) 2015-08-04 US disclosed
US-9096645-B2 Dipeptide analogs for treating conditions associated with amyloid fibril formation RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) 2015-08-04 US disclosed
US-20150079163-A1 ANTIMICROBIAL COMPOUNDS AND METHODS OF USE NEXMED HOLDINGS, INC. 2015-03-19 US disclosed
CN-1993327-B 3-carbamoyl-2-pyridone derivatives SHIONOGI & CO 2013-02-06 CN disclosed
US-20120238750-A1 AROMATIC COMPOUND OTSUKA PHARMACEUTICAL CO., LTD. 2012-09-20 US disclosed
US-8236826-B2 Diarylether derivatives as antitumor agents OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2012-08-07 US disclosed
US-8188277-B2 Aromatic compounds for suppressing the generation of collagen OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2012-05-29 US disclosed
US-20100004438-A1 DIARYLETHER DERIVATIVES AS ANTITUMOR AGENTS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2010-01-07 US disclosed
US-20070270422-A1 Aromatic Compounds OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2007-11-22 US disclosed
US-20070270422-A1 Aromatic Compounds OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2007-11-22 US disclosed
WO-2007066784-A2 DIARYLETHER DERIVATIVES AS ANTITUMOR AGENTS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2007-06-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10179102-B2 Hair conditioner for wavy and curly hair ITCH, PARG, GABBR1 CYP4F2 4455/4885CYP4A11 4519/4885ALDH1A1 3815/4885
US-20180185264-A1 HAIR CONDITIONER FOR WAVY AND CURLY HAIR ITCH, PARG, GABBR1 CYP4F2 4455/4885CYP4A11 4519/4885ALDH1A1 3815/4885
US-20150079163-A1 ANTIMICROBIAL COMPOUNDS AND METHODS OF USE CLPP, POLR1C, NACA CYP4F2 4590/4885CYP4A11 4617/4885ALDH1A1 2055/4885
US-20120238750-A1 AROMATIC COMPOUND CBR1, CBR3, CYP1A1 CYP4F2 546/4885CYP4A11 159/4885ALDH1A1 565/4885
US-20230365608-A1 ANTIVIRAL NUCLEOSIDES AND DERIVATIVES THEREOF PNP, NUDT1, ADAR CYP4F2 3402/4885CYP4A11 2615/4885ALDH1A1 3258/4885
US-20100004438-A1 DIARYLETHER DERIVATIVES AS ANTITUMOR AGENTS ROS1, CBR1, CBR3 CYP4F2 2279/4885CYP4A11 1486/4885ALDH1A1 265/4885
US-20070270422-A1 Aromatic Compounds COL1A1, COL2A1, COL14A1 CYP4F2 435/4885CYP4A11 183/4885ALDH1A1 475/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.