Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.40 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9301877 | 0.88 | BACE1 (0.43) | DRD4DRD2CHRM2CHRM3FAAH | |
| SCHEMBL9301593 | 0.84 | SIGMAR1 (0.48) | SIGMAR1KDM4EALDH1A1MAPTDRD4 | |
| SCHEMBL9301890 | 0.81 | L3MBTL1 (0.46) | KDM4EALDH1A1MAPT | |
| SCHEMBL9302550 | 0.78 | ADRA1A (0.53) | SIGMAR1KDM4EALDH1A1MAPTDRD4 | |
| SCHEMBL9301121 | 0.72 | ACHE (0.45) | SIGMAR1MAPTDRD4HTR1A | |
| SCHEMBL9300946 | 0.72 | NPC1 (0.52) | SIGMAR1KDM4EALDH1A1HTR2BPOLB | |
| SCHEMBL22674304 | 0.71 | SIGMAR1 (0.65) | SIGMAR1KDM4EALDH1A1MAPTDRD4 | |
| SCHEMBL9302817 | 0.71 | AIMP2 (0.53) | SIGMAR1KDM4EALDH1A1MAPTDRD4 | |
| SCHEMBL9301861 | 0.70 | BACE1 (0.49) | ALDH1A1DRD4DRD2CHRM2CHRM3 | |
| SCHEMBL9302183 | 0.70 | CYP2D6 (0.44) | ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5286735-A | Antidepressants, anxiolytic agents | PIERRE FABRE MEDICAMENT (FR) | 1994-02-15 | — | — | US | claimed |
| US-5286735-A | Antidepressants, anxiolytic agents | PIERRE FABRE MEDICAMENT (FR) | 1994-02-15 | — | — | US | disclosed |